Therapeutic Heat and Cold in the Management of Pain

Waldman, Steven D.; Kidder, Katherine A.; Waldman, Howard J.

doi:10.1016/b978-1-4377-0721-2.00133-1

Cited by 1 publication

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The drug may act in the inhibition of motor neurons leading to skeletal muscle relaxation. Chlorzoxazone is metabolized in the liver and excreted through the urine [4, 5]. The quantification of the available impurities in the drug product will play a vital role in pharmaceutical industries.…”

Section: Introductionmentioning

confidence: 99%

Stability‐indicating method for quantification of potential genotoxic impurity and other organic impurities of chlorzoxazone using hyphenated techniques

Nagulancha,

Rao

2023

Separation Science Plus

View full text Add to dashboard Cite

A simple, reliable, and stability‐indicating RP‐HPLC‐UV method was developed and validated for the estimation of related substances (p‐chlorophenol and unknown impurities) of chlorzoxazone (skeletal muscle relaxant). Along with this as the compound contains a potential genotoxic impurity (2‐amino‐4‐chlorophenol), which needs to have more sensitivity in quantification, we have also developed and validated a separate RP‐HPLC‐mass spectrometry (MS)/MS method for the estimation of 2‐amino‐4‐chlorophenol impurity. Both methods (RP‐HPLC‐UV & RP‐HPLC–MS/MS) were validated in accordance with International Council for Harmonization Q2(R1) and were found to be precise, accurate, robust, linear, and specific with limit of quantification values established with respect to 100% of test concentration, 0.018% w/w of p‐chlorophenol by RP‐HPLC‐UV, and 2 ppm of 2‐amino‐4‐chlorophenol by RP‐HPLC–MS.

show abstract

Section: Introductionmentioning

confidence: 99%