Therapeutic hypothermia in acute traumatic spinal cord injury

Collis, James

doi:10.1136/jramc-2017-000792

Cited by 4 publications

(3 citation statements)

References 104 publications

(134 reference statements)

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“…However, current therapies are largely ineffective at restoring neural structure and function following SCI. Furthermore, the limitations of existing treatments create difficulties in providing long-term protection from additional spinal cord damage during recovery [7,8]. In recent years, cellbased approaches have been used to treat SCI separately or in combination with other strategies [9].…”

Section: Introductionmentioning

confidence: 99%

3D bioprinting approaches for spinal cord injury repair

Jiu,

Liu,

et al. 2024

Biofabrication

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Regenerative healing of spinal cord injury poses an ongoing medical challenge by causing persistent neurological impairment and a significant socioeconomic burden. The complexity of spinal cord tissue presents hurdles to successful regeneration following injury, due to the difficulty of forming a biomimetic structure that faithfully replicates native tissue using conventional tissue engineering scaffolds. 3D bioprinting is a rapidly evolving technology with unmatched potential to create 3D biological tissues with complicated and hierarchical structure and composition. With the addition of biological additives such as cells and biomolecules, 3D bioprinting can fabricate preclinical implants, tissue or organ-like constructs, and in vitro models through precise control over the deposition of biomaterials and other building blocks. This review highlights the characteristics and advantages of 3D bioprinting for scaffold fabrication to enable spinal cord injury repair, including bottom-up manufacturing, mechanical customization, and spatial heterogeneity. This review also critically discusses the impact of various fabrication parameters on the efficacy of spinal cord repair using 3D bioprinted scaffolds, including the choice of printing method, scaffold shape, biomaterials, and biological supplements such as cells and growth factors. High-quality preclinical studies are required to accelerate the translation of 3D bioprinting into clinical practice for spinal cord repair. Meanwhile, other technological advances will continue to improve the regenerative capability of bioprinted scaffolds, such as the incorporation of nanoscale biological particles and the development of 4D printing.

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Section: Introductionmentioning

confidence: 99%

3D bioprinting approaches for spinal cord injury repair

Jiu,

Liu,

et al. 2024

Biofabrication

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“…Cold shock alters cellular signalling and causes a broad spectrum of physiological changes. A mild decrease in physiological temperature, or hypothermia, confers neuroprotective effects on spinal cord injury and cardiac damage [1][2][3][4]. Hypothermia also improves the development of brain edema and intracranial hypertension in acute liver failure [5].…”

Section: Introductionmentioning

confidence: 99%

Deregulation of HSF1‐mediated endoplasmic reticulum unfolded protein response promotes cisplatin resistance in lung cancer cells

et al. 2022

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Mild hypothermia can induce apoptotic cell death in many cancer cells, but the underlying mechanisms remain unclear. In a genetic screen in Caenorhabditis elegans, we found that impaired endoplasmic reticulum unfolded protein response (UPR ER ) increased animal survival after cold shock. Consistently, in normal human lung cells, decreasing culture temperature from 37 to 30 °C activated UPR ER and promoted cell death. However, lung adenocarcinoma cells were impaired in UPR ER induction and resistant to hypothermia-induced cell death. Mechanistically, hypothermic stress increased HSF1 levels, which in turn activated UPR ER to promote apoptotic cell death. HSF1 expression was associated with UPR ER genes in normal tissues, but such association was lost in many cancers, especially lung adenocarcinoma. Activating UPR ER enhanced the cytotoxicity of chemotherapy drugs cisplatin preferentially in cancer cells. Consistently, cancer patients with higher UPR ER expression had generally better prognosis. Together, our study on hypothermia has led to the discovery of HSF1-UPR ER in the regulation of drug sensitivity in lung cancer cells, providing novel thoughts on developing new strategies against chemoresistance.

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“…Researchers have attempted to identify new treatments, such as drug administration, surgical decompression, hypothermia, and stem cells therapies, which could promote nerve cell regeneration, repair damaged parts, reduce the metabolic rate, and suppress acute inflammatory processes (to protect central nerve tissue from continued injury following traumatic damage) [5,6]. Recently, new therapeutic methods, such as cell/gene therapy, motor exercises, electrical stimulation, electrochemical neuromodulation therapy, and stem cell-based therapies, have been used, alone or in a combinatory approach, to achieve successful SCI therapy [7].…”

Section: Introductionmentioning

confidence: 99%

Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms

Zarepour

Hooshmand

Gökmen

et al. 2021

Cells

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Spinal cord injury (SCI) has a major impact on affected patients due to its pathological consequences and absence of capacity for self-repair. Currently available therapies are unable to restore lost neural functions. Thus, there is a pressing need to develop novel treatments that will promote functional repair after SCI. Several experimental approaches have been explored to tackle SCI, including the combination of stem cells and 3D bioprinting. Implanted multipotent stem cells with self-renewing capacity and the ability to differentiate to a diversity of cell types are promising candidates for replacing dead cells in injured sites and restoring disrupted neural circuits. However, implanted stem cells need protection from the inflammatory agents in the injured area and support to guide them to appropriate differentiation. Not only are 3D bioprinted scaffolds able to protect stem cells, but they can also promote their differentiation and functional integration at the site of injury. In this review, we showcase some recent advances in the use of stem cells for the treatment of SCI, different types of 3D bioprinting methods, and the combined application of stem cells and 3D bioprinting technique for effective repair of SCI.

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Therapeutic hypothermia in acute traumatic spinal cord injury

Cited by 4 publications

References 104 publications

3D bioprinting approaches for spinal cord injury repair

3D bioprinting approaches for spinal cord injury repair

Deregulation of HSF1‐mediated endoplasmic reticulum unfolded protein response promotes cisplatin resistance in lung cancer cells

Spinal Cord Injury Management through the Combination of Stem Cells and Implantable 3D Bioprinted Platforms

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