Therapeutic Hypothermia in Intensive Care Unit: Meta-Analysis

Alqalyoobi, Shehabaldin; Sarkeshik, Amir A.; Boctor, Noelle; Hoerger, Joshua; Klimberg, N.; Stewart, Susan L.; Albertson, Timothy E

doi:10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4131

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“…One discovery of the past few decades (at both organismal and molecular levels) that had a potential for therapy was the decrease in metabolism during hypoxia, a response that attempts to minimize the mismatch between O 2 supply and demand [44][45][46][47] . This discovery, however, did not materialize into a real effective therapy, as the clinical trials of brain cooling, for example, to lower brain metabolism in patients suffering from brain hypoxia or ischemia, were largely inconclusive 48 . Another discovery that focused our efforts on understanding high-altitude adaptation is that some of the genes obtained from these studies played a substantial role in protecting mammalian organs from injury when severely deprived of oxygen 49,50 .…”

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confidence: 99%

Multiple mechanisms drive genomic adaptation to extreme O2 levels in Drosophila melanogaster

et al. 2021

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To detect the genomic mechanisms underlying evolutionary dynamics of adaptation in sexually reproducing organisms, we analyze multigenerational whole genome sequences of Drosophila melanogaster adapting to extreme O2 conditions over an experiment conducted for nearly two decades. We develop methods to analyze time-series genomics data and predict adaptive mechanisms. Here, we report a remarkable level of synchronicity in both hard and soft selective sweeps in replicate populations as well as the arrival of favorable de novo mutations that constitute a few asynchronized sweeps. We additionally make direct experimental observations of rare recombination events that combine multiple alleles on to a single, better-adapted haplotype. Based on the analyses of the genes in genomic intervals, we provide a deeper insight into the mechanisms of genome adaptation that allow complex organisms to survive harsh environments.

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Section: Discussionmentioning

confidence: 99%

Multiple mechanisms drive genomic adaptation to extreme O2 levels in Drosophila melanogaster

et al. 2021

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“…Therapeutic hypothermia can reduce cerebral metabolism and cerebral blood volume ( 4 ). Mild hypothermia (32–34°C) may effectively decrease intracranial pressure ( 9 ). However, recent evidence demonstrated that early or prophylactic hypothermia can be detrimental in TBI patients ( 9 , 10 ).…”

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confidence: 99%

Editorial: Crucial Decisions in Severe Traumatic Brain Injury Management: Criteria for Treatment Escalation

Robba

Jagt

2021

Front. Neurol.

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Therapeutic Hypothermia in Intensive Care Unit: Meta-Analysis

Cited by 2 publications

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Multiple mechanisms drive genomic adaptation to extreme O2 levels in Drosophila melanogaster

Multiple mechanisms drive genomic adaptation to extreme O2 levels in Drosophila melanogaster

Editorial: Crucial Decisions in Severe Traumatic Brain Injury Management: Criteria for Treatment Escalation

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