Therapeutic Hypothermia Reduces Oxidative Damage and Alters Antioxidant Defenses after Cardiac Arrest

Hackenhaar, Fernanda Schäfer; Medeiros, Tássia Machado; Heemann, Fernanda Maciel; Behling, Camile S.; Putti, Jordana Salete; Mahl, Camila D.; Verona, Cléber; Silva, Ana Carolina A. da; Guerra, Maria Cristina; Gonçalves, Carlos Alberto; Oliveira, Vanessa Martins de; Riveiro, Diego Fontoura Mendes; Vieira, Sílvia Regina Rios; Benfato, Mara da Silveira

doi:10.1155/2017/8704352

Cited by 41 publications

(35 citation statements)

References 41 publications

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“…who also reported an increased GST activity following 33°C hypothermia in post cardiac arrest patients for up to 72 hours. 59 Since an increased GST activity has been commonly associated with reduced oxidative damage 60 and AILI is largely mediated by towering oxidative stress, 61 this further substantiates the potential molecular effects of hypothermia desirable for alleviating AILI, rather than a subdued thermodynamic rate. While the functional impact of moderate hypothermia on liver metabolism appears variable, most perturbations which occurred during cooling are rapidly reversible with a 24-hour rewarming ( Figure 7 ).…”

Section: Discussionmentioning

confidence: 89%

Moderate Hypothermia Effectively Alleviates Acetaminophen-Induced Liver Injury With Prolonged Action Beyond Cooling

Tan

Tey

2020

Dose-Response

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Acetaminophen (APAP) overdose accounts for the highest incidence of acute liver failure, despite the availability of an antidote i.e. N-acetylcysteine. This calls for alternative strategies to manage APAP-induced liver injury (AILI). Therapeutic hypothermia has been explored in past studies for hepatoprotection, but these phenomenal reports lack clarification of its optimal window for application, and mechanistic effects in specific AILI. Hence, we conducted an in vitro study with transforming growth factor-α transgenic mouse hepatocytes cell line, TAMH, and human liver hepatocytes cell line, L-02, where cells were conditioned with deep (25°C) or moderate (32°C) hypothermia before, during or after APAP toxicity. Cell viability was evaluated as a hallmark of cytoprotection, along with cell death. Simultaneously, cold shock proteins (CSPs) and heat shock proteins expressions were monitored; key liver functions including drug-metabolizing ability and hepatic clearance were also investigated. Herein, we demonstrated significant hepatoprotection with 24-hour moderate hypothermic conditioning during AILI and this effect sustained for at least 24 hours of rewarming. Such liver preservation was associated with a CSP—RNA-binding motif protein 3 (RBM3) as its knockdown promptly abolished the cytoprotective effects of hypothermia. With mild and reversible liver perturbations, hypothermic therapy appears promising and its RBM3 involvement deserves future exploration.

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Section: Discussionmentioning

confidence: 89%

Moderate Hypothermia Effectively Alleviates Acetaminophen-Induced Liver Injury With Prolonged Action Beyond Cooling

Tan

Tey

2020

Dose-Response

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“…(8,9) The neuroprotective mechanisms of TTM include the attenuation of oxidative stress and antiinflammatory effects. (10)(11)(12)(13) However, recent studies reported that TTM does not exert beneficial effects on cytokine levels in PCAS. (6,(14)(15)(16)(17) Molecular hydrogen (H 2 ) is a mild antioxidant that selectively reduces highly active oxidants such as hydroxyl radicals and peroxynitrites.…”

mentioning

confidence: 99%

Hydrogen gas inhalation alleviates oxidative stress in patients with post-cardiac arrest syndrome

Tamura

Suzuki

Hayashida

et al. 2020

J. Clin. Biochem. Nutr.

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Oxidative stress plays a key role in the pathophysiology of post cardiac arrest syndrome. Molecular hydrogen reduces oxidative stress and exerts anti inflammatory effects in an animal model of cardiac arrest. However, its effect on human post cardiac arrest syndrome is unclear. We consecutively enrolled five comatose post cardiac arrest patients (three males; mean age, 65 ± 15 years; four cardiogenic, one septic cardiac arrest) and evaluated temporal changes in oxidative stress markers and cytokines with inhaled hydrogen. All patients were treated with target temperature management. Hydrogen gas inhalation (2% hydrogen with titrated oxygen) was initiated upon admission for 18 h. Blood hydrogen concentrations, plasma and urine oxidative stress markers (derivatives of reactive oxygen metabolites, biological antioxidant potential, 8 hydroxy 2' deoxyguanosine, N ε hexanoyl lysine, lipid hydroperoxide), and cytokines (interleukin 6 and tumor necrosis factor α) were measured before and 3, 9, 18, and 24 h after hydrogen gas inhalation. Arterial hydrogen concentration was measurable and it was equilibrated with inhaled hydrogen. Oxidative stress was reduced and cytokine levels were unchanged in cardiogenic patients, whereas oxidative stress was unchanged and cytokine levels were diminished in the septic patient. The effect of inhaled hydrogen on oxidative stress and cytokines in comatose post cardiac arrest patients remains indefinite because of methodological weaknesses.

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“…Yaşın bir yıl artmasının ölüm riskini %4 arttırdığı gösterildi. Hipotermi KA sonrası oksidatif hasarı azaltmaktadır ve nörolojik prognoz üzerine etkilerinin olumlu olduğu belirtilmiştir (23)(24)(25). Wibrandt ve ark.…”

Section: Gereç Ve Yöntemunclassified

Factors Affecting Prognosis in Hypoxic Encephalopathy Patients Followed-up in Intensive Care Unit

Yılmaz¹,

Erdoğan²,

Kizilaslan³

et al. 2019

atfm

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Objectives: Hypoxic encephalopathy (HE) after cardiac arrest is a clinical condition that can cause severe neurological sequelae and death. It is important to determine the prognosis in patients with HE for follow up and developing future treatments in the long term. Our aim was to investigate the effects of age, gender, hypothermia, lesion site in brain magnetic resonance imaging (MRI), seizure and electroencephalography (EEG) findings on prognosis in patients with the diagnosis of HE. Materials and Methods: The data of the adult intensive care unit was evaluated retrospectively. A total of 194 patients with HE were included into the study. One hundred and eighteen (60.8%) of the patients were male and 76 (39.2%) were female. The survivors and those who died were identified. Hypothermia therapy, brain MRI findings (cortical and/or subcortical lesion), presence of seizures (myoclonic, generalized, focal) and EEG findings (epileptic activity, status, generalized slowing) were recorded. Results: The mean age was 59.46±1.71 (18-89). Seventy-six (39.2%) patients underwent hypothermia. One hundred and seven (55.2%) patients died. The rate of exitus in elderly patients was significantly higher (p<0.01). The brain MRI of 88 patients showed hypoxic lesions (cortical in 8 patients, subcortical in 21 patients, cortical + subcortical lesion in 59 patients). The survival rate of the patients with cortical or subcortical pathology is significantly higher than patients with both pathology (p<0.01). As a result of multiple regression analysis, a 1-year increase in age, increased the

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Therapeutic Hypothermia Reduces Oxidative Damage and Alters Antioxidant Defenses after Cardiac Arrest

Cited by 41 publications

References 41 publications

Moderate Hypothermia Effectively Alleviates Acetaminophen-Induced Liver Injury With Prolonged Action Beyond Cooling

Moderate Hypothermia Effectively Alleviates Acetaminophen-Induced Liver Injury With Prolonged Action Beyond Cooling

Hydrogen gas inhalation alleviates oxidative stress in patients with post-cardiac arrest syndrome

Factors Affecting Prognosis in Hypoxic Encephalopathy Patients Followed-up in Intensive Care Unit

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