Therapeutic impact of statins on the lipid profile and cardiovascular risk of patients with rheumatoid arthritis: Systematic literature review and meta-analysis

Statins and autoimmunity: State-of-the-art

“…To further our understanding on the potential benefits of statins in RA patients, Munoz et al conducted a meta-analysis in which all randomized and non-randomized clinical trials were analyzed to evaluate the effect of statins on mortality, cardiovascular complications, lipid fractions, and disease activity in RA patients. Results of Munoz et al showed that statin therapy significantly reduced total cholesterol, LDLc, and TG levels, without significantly altering HDL-c. Disease activity also improved mildly over a three-month period as reflected by the values of the DAS28 index (Muñoz, Carrasco, Castelblanco, García, & Fernández-Avila, 2019). Another general population-based cohort study by Schoenfeld et al, confirmed that statin use was associated with a lower overall mortality risk in RA patients (Schoenfeld et al, 2016).…”