Therapeutic implications of assessment of serum zinc levels in patients with vitiligo: A patient controlled prospective study

Zaki, Amr Mohamed; Nada, Ahmed S.; Elshahed, Ahmed Rashad; Abdelgawad, Nour H.; Jafferany, Mohammad; Elsaie, Mohamed L.

doi:10.1111/dth.13998

Cited by 12 publications

(13 citation statements)

References 12 publications

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“…A case-control study by Basha MA et al 18 in 2015 which involved 60 patients and 60 controls observed no significant correlation of serum zinc with age of onset (p value=0.04) or disease duration (p value=0.65). Similar observations were made by Zaki et al 19 2020. In contrast, Mirnezami M et al 20 in 2018 found a significantly lower serum zinc level associated with longer vitiligo duration.…”

Section: Discussionsupporting

confidence: 90%

Evaluation of Serum Zinc Concentration in Vitiligo, A Case-Control Study

Ahmed

Abdulqader³

et al. 2020

Preprint

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Background: Vitiligo is an acquired autoimmune pigmentary disorder characterized by ivory white patches. Zinc is proposed to have an immune modulatory, antioxidant and antiapoptotic properties in vitiligo patients.The aim of this study is to evaluate serum zinc in vitiligo patients. Patients and methods: This is case control study conducted from December 2019 to May 2020. The study included 50 patient with vitiligo and 50 age- and sex-matched controls.A 2 ml venous blood sample was taken from patients and controls by zinc-free syringe and was measured by atomic absorption spectrophotometry. Results: The mean serum zinc level was 73.14+19.32 in patients group and 85.36+14.14 in controls group (p-value=0.005). It also was 77.65+22.07 and 82.84+14.32 in male patients and controls, respectively. In female patients, it was 70.82+17.65and in female controls was 82.88+13.79(p-value=0.02). Regarding the residence, the mean serum zinc level in patients group was 70.13+21.4 in urban and 76.39+17.73 in rural area. In controls group, mean serum zinc was 83.25+14.12 and 89.11+13.77 in urban and rural area, respectively (p-value=0.003). According to the clinical patterns of vitiligo, the mean serum zinc observed was 75.32+19.64 in vitiligo vulgaris, 70.45+21.23 in acrofacial vitiligo and 68.7+17.61 in segmental vitiligo (p-value=0.68). Conclusion: Serum zinc level was significantly low in patients with vitiligo but not associated with the type of vitiligo or family history of autoimmune diseases. It was even lower when vitiligo is associated with nail changes than vitiligo without any nail abnormalities.

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Section: Discussionsupporting

confidence: 90%

Evaluation of Serum Zinc Concentration in Vitiligo, A Case-Control Study

Ahmed

Abdulqader³

et al. 2020

Preprint

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“…Most of studies revealed low levels while others showed normal or even high level, this may be explained by some nutritional factors as excessive supplement therapy, differences in diet quality, zinc concentration in soil, consumption of large amount of phytate, in addition to an important factor which is the inequality in cut-off point of normal zinc levels [21]. Our study considered 46 ug/dl as the low limit of normal zinc level, while other studies revealed a higher reference level, for example Zaki et al [21] considered the low limit of normal zinc level was 65 ug/dl. Also, Rostami mogaddam et al [22] considered the low limit of normal zinc level 70 ug/dl and Zn deficiency was described as a serum Zn level <70ug/dL.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Serum Zinc Level in Some Pigmentary Skin Disorders

Ali

Mabrouk

Fawzy

et al. 2022

JAMMR

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Background: Pigmentary disorders are a common presentation in dermatology and the appearance of either hypopigmentation or hyperpigmentation can be a major psychosocial problem to the patients. Melanin pigment is the most important substance determining human skin color. It produced by melanocyte cells during melanogenesis. Zinc in combination with other micronutrients has an essential function in melanogenesis process. Aim of Work: The aim of the study was to assess serum zinc level in patients with pigmentary disorders compared to healthy control subjects. Patients and Methods: This study was carried out on a total of 189 patients with pigmentary disorders (96 with hypopigmented and 93 with hyperpigmented disorders) and 50 apparently healthy controls. Serum zinc level was measured in all groups using a Flame Atomic Absorption Spectrophotometer. Results: The mean serum zinc level was in the hypopigmented, hyperpigmented disorders patients were 71.87 ± 20.23 and 72.36 ± 18.69, respectively, while the mean serum zinc level in controls was 87.48 ± 31.50, with the serum zinc level in patients with hypopigmented disorders was significantly lower than in healthy controls (P < 0.05). The average zinc level in the three groups was found to be within the normal reference range. Conclusion: Serum zinc level was within normal range in both patients and control groups. On the other hand, serum zinc level in pigmentary disorders was lower than that of control group with a statistically significance difference only between hypo pigmented disorders and control group.

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“…Vitiligo is a primary, localized, or generalized depigmentation of the skin and mucosa. Several studies have found that zinc levels in patients with vitiligo are lower than in controls ( 105 – 108 ). There are very few studies on the role of zinc in therapy, and only Yahoobi et al reported a clinical trial comparing the therapeutic effect of topical corticosteroids to a combination of oral zinc sulfate and topical corticosteroids.…”

Section: Pigmental Diseasesmentioning

confidence: 99%

Trace element zinc and skin disorders

Pan

Yang

et al. 2023

Front. Med.

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Zinc is a necessary trace element and an important constituent of proteins and other biological molecules. It has many biological functions, including antioxidant, skin and mucous membrane integrity maintenance, and the promotion of various enzymatic and transcriptional responses. The skin contains the third most zinc in the organism. Zinc deficiency can lead to a range of skin diseases. Except for acrodermatitis enteropathic, a rare genetic zinc deficiency, it has also been reported in other diseases. In recent years, zinc supplementation has been widely used for various skin conditions, including infectious diseases (viral warts, genital herpes, cutaneous leishmaniasis, leprosy), inflammatory diseases (hidradenitis suppurativa, acne vulgaris, rosacea, eczematous dermatitis, seborrheic dermatitis, psoriasis, Behcet's disease, oral lichen planus), pigmentary diseases (vitiligo, melasma), tumor-associated diseases (basal cell carcinoma), endocrine and metabolic diseases (necrolytic migratory erythema, necrolytic acral erythema), hair diseases (alopecia), and so on. We reviewed the literature on zinc application in dermatology to provide references for better use.

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Therapeutic implications of assessment of serum zinc levels in patients with vitiligo: A patient controlled prospective study

Cited by 12 publications

References 12 publications

Evaluation of Serum Zinc Concentration in Vitiligo, A Case-Control Study

Evaluation of Serum Zinc Concentration in Vitiligo, A Case-Control Study

Evaluation of the Serum Zinc Level in Some Pigmentary Skin Disorders

Trace element zinc and skin disorders

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