Therapeutic Implications of Diet in Inflammatory Bowel Disease and Related Immune-Mediated Inflammatory Diseases

Jiang, Yan; Jarr, Karolin; Layton, Cosima; Gardner, Christopher D.; Ashouri, Judith F.; Abreu, María T.; Sinha, S.

doi:10.3390/nu13030890

Cited by 51 publications

(25 citation statements)

References 84 publications

(106 reference statements)

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“…In contrast, the (non-treated) healthy co-twin had a more in ammatory gut microbiota. Finally, differences in diet between these twins may have in uenced the results 51,52 .…”

Section: Discussionmentioning

confidence: 99%

Inflammatory potential of gut microbiota from monozygotic twin pair discordant for ulcerative colitis

Knudsen

Zachariassen

Strube

et al. 2022

Preprint

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Gut microbiota perturbations are common in inflammatory bowel disease (IBD), including ulcerative colitis (UC), but it is unclear whether this is a result of the disease or a contributing factor. In twin pairs discordant for IBD, the healthy co-twin is at an increased risk of IBD and has a gut microbiota more similar to IBD patients than healthy individuals. Moreover, appropriate medical treatment may reduce the perturbations. To investigate the association of the microbiota and IBD, we transferred stool from a discordant twin pair, i.e. one healthy and one treated for UC, to germ-free mice by the inoculation of pregnant dams. Dextran sodium sulfate was used to induce colitis in the pups. Offspring of mice inoculated with stool from the UC twin had a lower disease activity index (DAI) and gut inflammation and microbiota with higher alpha diversity and a more anti-inflammatory profile, with the exclusive presence of the anti-inflammatory Akkermansia species, compared to offspring of mice inoculated with stool from the healthy co-twin. These results indicate that the healthy twin had a more inflammatory microbiota than the twin treated for UC. Our study suggests that individuals genetically susceptible to IBD have a more inflammatory gut microbiota. Future studies should assess the potential use of individual gut microbiota inflammatory profiles in personalised medicine.

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“…In contrast, the (non-treated) healthy co-twin had a more in ammatory gut microbiota. Finally, differences in diet between these twins may have in uenced the results 51,52 .…”

Section: Discussionmentioning

confidence: 99%

Inflammatory potential of gut microbiota from monozygotic twin pair discordant for ulcerative colitis

Knudsen

Zachariassen

Strube

et al. 2022

Preprint

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“…More large-scale randomized studies on these pathologies are necessary in humans to provide concrete nutritional recommendations. Currently, in addition to the Mediterranean diet, the low FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) diet is of special interest for patients with pathologies that have greater intestinal involvement, such as IBD [ 116 ]. Additionally, as we have seen previously, due to its ability to manufacture anti-inflammatory peptides, antioxidants, and neurotransmitters, gut microbiota as a therapeutic target enhanced through diet and probiotic supplements in different IMIDs represent an interesting research topic.…”

Section: Imid Treatments and Their Optimization From The Pniementioning

confidence: 99%

Immune-Mediated Diseases from the Point of View of Psychoneuroimmunoendocrinology

Ortega

García-Montero

Fraile-Martínez

et al. 2022

Biology

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Immune-mediated inflammatory diseases (IMIDs) represent a large group of diseases (Crohn’s, ulcerative colitis, psoriasis, lupus, and rheumatoid arthritis) evidenced by systemic inflammation and multiorgan involvement. IMIDs result in a reduced quality of life and an economic burden for individuals, health care systems, and countries. In this brief descriptive review, we will focus on some of the common biological pathways of these diseases from the point of view of psychoneuroimmunoendocrinology (PNIE). PNIE consists of four medical disciplines (psychology, nervous system, immune system, and endocrine system), which are key drivers behind the health–disease concept that a human being functions as a unit. We examine these drivers and emphasize the need for integrative treatments that addresses the disease from a psychosomatic point of view.

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“…In recent times, humans are experiencing unprecedented environmental changes involving exposure to unhealthy diet, air pollution, fabrics made from synthetic fibers, and hygiene-related products that are harsh on the skin as well as ease of access to antibiotics, general pharmaceuticals, and quasi-drugs [ 2 ]. These changes in environmental factors may be unregulated and lead to induction of inflammatory processes that can in turn lead to homeostatic imbalance and pathologies such as chronic colitis [ 3 ], rheumatic diseases and arterial stiffness [ 4 ], fatty liver diseases [ 5 ], cancer [ 6 ], obesity and asthma [ 7 ], and sepsis [ 8 ]. The increase in human life expectancy in industrialized countries has resulted in a decrease in mortality.…”

Section: Introductionmentioning

confidence: 99%

Treatment with Commelina communis Extract Exerts Anti-inflammatory Effects in Murine Macrophages via Modulation of the Nuclear Factor-κB Pathway

Kim

Park

You

2022

Mediators of Inflammation

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The incidence of severe inflammatory diseases caused by chronic inflammation has increased owing to unprecedented changes brought about by industrialization. In this study, we aimed to assess the effect of treatment of lipopolysaccharide- (LPS-) induced murine macrophages with Commelina communis Linne extract (CCE) on synthesis of nitric oxide (NO), hypersecretion of proinflammatory cytokines, intranuclear transition of the p65 subunit of nuclear factor- (NF-) κB, and degradation of the NF-κB inhibitor IκBα. Notably, CCE treatment did not affect cell viability even at a final concentration of 1.5 mg/mL. At a high concentration of CCE, the LPS-induced high levels of NO, tumor necrosis factor-α, interleukin- (IL-) 1β, and IL-6 were decreased via downregulation of inducible NO synthase and proinflammatory cytokine mRNA expression. Furthermore, phosphorylation of IκBα was significantly decreased upon CCE treatment, and the intranuclear transition of NF-κB p65 triggered by LPS was inhibited at a high concentration of CCE. Polyphenols and flavonoids, secondary metabolites in CCE that regulate the NF-κB pathway, may be responsible for its anti-inflammatory activity. We suggest that CCE has anti-inflammatory effects related to suppression of the NF-κB pathway and can be used to treat chronic inflammation.

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Therapeutic Implications of Diet in Inflammatory Bowel Disease and Related Immune-Mediated Inflammatory Diseases

Cited by 51 publications

References 84 publications

Inflammatory potential of gut microbiota from monozygotic twin pair discordant for ulcerative colitis

Inflammatory potential of gut microbiota from monozygotic twin pair discordant for ulcerative colitis

Immune-Mediated Diseases from the Point of View of Psychoneuroimmunoendocrinology

Treatment with Commelina communis Extract Exerts Anti-inflammatory Effects in Murine Macrophages via Modulation of the Nuclear Factor-κB Pathway

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