Therapeutic Importance and Pharmacological Activities of Karanjin in the Medicine for the Treatment of Human Disorders: A Review through Scientific Data Analysis

Abstract

Backgrounds: Plant and derived herbal drugs have been used in the traditional system of medicine for the treatment of various forms of human health complications since a very early age. Commercial products prepared from natural herbs have been always valuable for the society in the form of health supplement to medicament. In the ancient time, herbal products were mainly prepared from plants and their derived phytochemical. Plants contain a rich source of pure phytochemical called secondary metabolite and examples are flavonoids, glycosides, tannins and terpenoids etc. Plants and their parts including fruits, flowers, vegetables etc. are the best source of Flavonoid class phytochemicals. Methods: Present work summarized the scientific information of karanjin for their health beneficial aspects and pharmacological activities including its analytical aspects. In the present investigation, scientific data of karanjin have been collected from various scientific databases such as Google, Goggle Scholar, Science Direct and PubMed and analyzed to know the health beneficial aspects of karanjin in the medicine. Further pharmacological activity data has been collected and analyzed in the present work to know their biological potential in the medicine. Analytical methods used for the separation, isolation, and identification of karanjin for the standardization of different natural products have been also discussed in the present work. Results: Scientific data analysis signified the biological importance of Flavonoid class phytochemicals in the medicine as they are well known for their anti-ischemic, vasodilatory, anti-bacterial, anti-inflammatory, anti-oxidant, anti-viral, and anti-cancer activities. Scientific data analysis revealed the presences of karanjin in numerous medicinal plants such as Fordia cauliflora, Lonchocarpus latifolius, Millettia pinnata, Millettia pubinervis, Pongamia pinnata, and Tephrosia purpurea. Pharmacological activity data revealed the biological potential of karanjin against cancerous disorders, glucose metabolism abnormalities, gastrointestinal disorders, arthritis, inflammatory disorders, colitis, psoriasis and brain related disorders. However, analytical data signified the importance of RP-HPLC, TLC, HPTLC, UPLC-ESI-MS/MS and HSCCC techniques in the medicine for the quantification of karanjin in different samples. Conclusion: Presented information about karanjin in this review paper will be beneficial to the scientific peoples of the world to know the health beneficial aspects of karanjin in the medicine.

The protective effect of karanjin against sepsis‐induced acute lung injury in mice is involved in the suppression of the TLR4 pathway

“…ALI/ARDS has remained a life‐threatening condition with an unacceptably high mortality, suggesting the need for novel therapeutic agents (Sauer et al., 2021; Walkey & Wiener, 2012). Given karanjin has anti‐inflammatory, antioxidant, antidiabetic, antibacterial, gastroprotective, and anti‐Alzheimer's properties with little side effects (Noor et al., 2020; Patel & Patel, 2022), it deserves further investigation for clinical translation.…”