Therapeutic importance of Zishen Yutai Pill on the female reproductive health: A review

Maharajan, Kannan; Xia, Qing; Duan, Xiuying; Tu, Pengfei; Yun, Zhong; Liu, Kechun

doi:10.1016/j.jep.2021.114523

Cited by 21 publications

(12 citation statements)

References 37 publications

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“…In this formula, dodder, mulberry, Atractylodes, Eucommia, and Tatsuya are used in combination to nourish the liver and kidney, as well as Qi and Yuan. Ginseng, Rehmannia glutinosa, and Polygonum multiflorum can invigorate the spleen and Qi, nourish blood, and soothe miscarriage [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Dydrogesterone Tablets Combined with Zishen Yutai Pills on Threatened Abortion in Early Pregnancy and Pregnancy Outcomes

Chen¹,

Qiu

Jin³

2022

Computational and Mathematical Methods in Medicine

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Objective. To explore the effect of dydrogesterone tablets combined with Zishen Yutai pills on threatened abortion in early pregnancy and pregnancy outcomes. Methods. This study retrospectively analyzed the clinical data of 100 patients with threatened abortion in early pregnancy who came to the Linhai Second People’s Hospital/Taizhou Municipal Hospital from January 13, 2021, to January 13, 2022. According to different treatment methods, 48 patients treated with progesterone injection were assigned to the control group (CG), while 52 cases with the combined therapy of dydrogesterone tablets and Zishen Yutai pills were assigned to the observation group (OG). The two groups were compared in terms of the following parameters: treatment efficacy, whole blood high shear viscosity, hematocrit (HCT), plasma fibrinogen (FIB) level, spiral artery pulsatility index (PI), uterine spiral artery blood flow resistance index (RI), lumbar and abdominal pain relief time, hemostasis time, estrogen levels, pregnancy outcomes, neonatal adverse outcomes, and incidence of adverse reactions. Results. Compared with CG, the therapeutic effect in OG was observed to be evidently better, and its pain relief time and hemostasis time in the waist and abdomen were markedly shorter. After treatment, the whole blood high shear viscosity, FIB, RI, PI, and estrogen levels of both groups improved statistically compared with those before treatment, with more significant improvements in OG compared with CG. OG was also superior to CG with markedly lower incidence of preterm birth, miscarriage, neonatal adverse outcomes, and adverse reactions and a drastically higher full-term pregnancy rate. Conclusion. Zishen Yutai pill combined with dydrogesterone tablets is of remarkable therapeutic effect in treatment of early threatened abortion, which can significantly improve clinical symptoms and pregnancy outcomes of patients, with a high safety profile, which is worthy of clinical application.

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Section: Introductionmentioning

confidence: 99%

Effects of Dydrogesterone Tablets Combined with Zishen Yutai Pills on Threatened Abortion in Early Pregnancy and Pregnancy Outcomes

Chen¹,

Qiu

Jin³

2022

Computational and Mathematical Methods in Medicine

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“…11 The Zishen Yutai Pill contains 15 Chinese traditional medicinal herbs. 12 It ameliorates advanced endometrial maturation through the upregulation of HOXA10, 13 and a high-dose Zishen Yutai Pill may up-regulate levels of transforming growth factor-b and improve oocyte function. 14 A metabonomic study suggested that metabolites changed after administration of the Zishen Yutai Pill were highly enriched in sphingolipids, alanine, aspartic acid, glutamic acid, taurine and hypotaurine metabolites, and aminoacyl tRNA biosynthesis.…”

Section: Discussionmentioning

confidence: 99%

Effects of the Zishen Yutai Pill Compared With Placebo on Live Births Among Women in a Fresh Embryo Transfer Cycle

Chen

Hao

Deng

et al. 2022

Obstetrics &Amp; Gynecology

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“…Although multiple monomeric compounds in the Zishen Yutai pills exerted their therapeutic effects in improving reproduction, the combined activity especially of those absorbed compounds into the blood circulation and their metabolites in vivo was poorly understood. Recently, the Zishen Yutai pills showed therapeutic effects on ovarian dysfunction such as diminished ovarian reserve, primary ovarian insufficiency, and polycystic ovary syndrome [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of action of Zishen Yutai pills in treating premature ovarian failure determined by integrating UHPLC-Q-TOF-MS and network pharmacology analysis

Dang

Zhang²,

Su³

et al. 2022

BMC Complement Med Ther

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Background Zishen Yutai (ZSYT) pill, a patent Chinese medicine, has been widely used in the treatment of infertility, abortion, and adjunctive treatment of in vitro fertilization (IVF) for decades. Recently, the results of clinical observations showed that premature ovarian failure (POF) patients exhibited improved expression of steroids and clinical symptoms associated with hormone disorders after treatment with Zishen Yutai pills. However, the pharmacological mechanism of action of these pills remains unclear. Methods The compounds of Zishen Yutai pills found in blood circulation were identified via ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) technique in the serum of POF mice after oral administration of Zishen Yutai pills. The potential targets of compounds were screened using Traditional Chinese Medicine Systems Pharmacology Database, Traditional Chinese Medicine Database@Taiwan, Drugbank Database, PubChem, HIT, Pharmapper, and Swiss Target Prediction. The target genes associated with POF were collected from Online Mendelian Inheritance in Man Database, PharmGkb, Genecards, Therapeutic Target Database, and Genetic Association Database. The overlapping genes between the potential targets of Zishen Yutai pills’ compounds and the target genes associated with POF were clarified via protein-protein interaction (PPI), pathway, and network analysis. Results Nineteen compounds in Zishen Yutai pills were detected in the serum of POF mice after oral administration. A total of 695 Zishen Yutai (ZSYT) pill-related targets were screened, and 344 POF-related targets were collected. From the results of Zishen Yutai (ZSYT) pill-POF PPI analysis, CYP19A1, AKR1C3, ESR1, AR, and SRD5A2 were identified as key targets via network analysis, indicating their core role in the treatment of POF with Zishen Yutai pills. Moreover, the pathway enrichment results suggested that Zishen Yutai pills treated POF primarily by regulating neuroactive ligand-receptor interaction, steroid hormone biosynthesis, and ovarian steroidogenesis. Conclusions Via virtual screening, we found that regulation of neuroactive ligand-receptor interaction, steroid hormone biosynthesis, and ovarian steroidogenesis was the potential therapeutic mechanism of Zishen Yutai pills in treating POF. Our study suggested that combining the analysis of Zishen Yutai pills’ compounds in blood in vivo in the POF model and network pharmacology prediction might offer a tool to characterize the mechanism of Zishen Yutai pills in the POF.

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Therapeutic importance of Zishen Yutai Pill on the female reproductive health: A review

Cited by 21 publications

References 37 publications

Effects of Dydrogesterone Tablets Combined with Zishen Yutai Pills on Threatened Abortion in Early Pregnancy and Pregnancy Outcomes

Effects of Dydrogesterone Tablets Combined with Zishen Yutai Pills on Threatened Abortion in Early Pregnancy and Pregnancy Outcomes

Effects of the Zishen Yutai Pill Compared With Placebo on Live Births Among Women in a Fresh Embryo Transfer Cycle

Mechanisms of action of Zishen Yutai pills in treating premature ovarian failure determined by integrating UHPLC-Q-TOF-MS and network pharmacology analysis

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