Therapeutic indication of caffeine and vitamin c on haematological profile in heparin, phenylhydrazine and aspirin induced haematological derangements in male Wistar rats

Abstract

Background: Caffeine and Vitamin C, key component in foods and beverages, have been investigated for potential haematological disease prevention. Aim: To lend credence to the above studies, the current study in Wistar rats evaluated the effects of caffeine and vitamin C in the management of haematological disorders in rats. Methods: Experimental animals were divided into three experimental phases (anaemic, leukocytopenic, and thrombocytopenic phases). Interventions with caffeine and vitamin C during anaemic, leukocytopenic, and thrombocytopenic phases were initiated for two weeks. Haematological parameters were all tested. All test, statistics were run using the Graph Pad Prism 8.1 at a confidence level of 0.05 or less (p-value). Results: After analysis, caffeine and vitamin C shows a significant increase in RBC, PCV, Hb count in the anaemic treated rats when compared to control. Similarly, there was a significant increase in platelet count in the thrombocytopenic treated rats when compared to untreated thrombocytopenic group. There was also a significant increase in monocyte, lymphocyte and neutrophil counts in leukocytopenic animals compared to luukocytopenic group untreated. Conclusion: In conclusion, this study suggests that caffeine and vitamin C have haemoprotective effects against anaemic, leukocytopenic and thrombocytopenic conditions.