There is a large variability in the personality of suicide attempters, but many personality traits and disorders have been consistently associated with suicidal behavior. In clinical settings, psychiatrists and psychologists must often face high-risk patients with marked personality traits, but they seldom investigate personality features to plan the subsequent treatment. This limitation is due to the diffi culty of a reliable assessment of personality, the frequent comorbidity with other mental disorders (including other Axis II disorders), and the lack of know-how to apply this information into targeted interventions. However, researchers are progressively carving the features of personality that interact with each other and with other risk factors, such as life events, to amplify the risk of a suicidal act. In this chapter we will review recent fi ndings and outline the options for intervention that are being opened.