Therapeutic interventions using a combination of Telmisartan and omega 3-fatty acids in sodium arsenite-induced vascular endothelial dysfunction in rats: modulation through ATP-sensitive K<sup>+</sup> channels and eNOS

Nirwane, Abhijit; Pawar, Vivek K.; Majumdar, Anuradha

doi:10.1515/jcim-2015-0009

Cited by 5 publications

(4 citation statements)

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“…Membrane fluidity ensures conduction and transmission of nerve signal [48,49]. EFAs ω-3 facilitate maintaining the normal structure and integrity of cell membranes.These interactions affect indirectly the structures related to membranes (ion channels and receptors and transporters) [50,51].…”

Section: The Role Of Efas In the Functioning Of Cnsmentioning

confidence: 99%

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Omega – 3 fatty acids in schizophrenia – part I: importance in the pathophysiology of schizophrenia

Róg

Karakuła-Juchnowicz

2016

Current Problems of Psychiatry

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Despite the increasing offer of antipsychotic drugs, the effectiveness of pharmacotherapy in schizophrenia is still unsatisfactory. Drug resistance, lack of complete remission and the increasing risk of metabolic complications are the reasons why the new forms of therapy in schizophrenia among which unsaturated essential fatty acids omega 3 (EFAs ω-3) affecting the proper functioning of nervous system, are mentioned, are being looked for.Fatty acids represent 50-60% of the dry weight of the brain and diet is one of the factors that influence the value of each of the fat fractions in the neuron membranes. Patients with schizophrenia tend to have irregular nutritional status concerning essential fatty acids ω-3, which might result from metabolic disorders or irregular consumption of fatty acids.Apart from being a review of the literature on this subject, this very paper characterizes essential fatty acids ω-3, their metabolism, the most important sources in the diet and the opinions of experts in the field about the recommended intake. It pays attention to the role of essential fatty acids in both the structure and functioning of the central nervous system is, as well as their role in the pathophysiology of schizophrenia, with particular emphasis on the membrane concept by David Horrobin. The assessment of the errors in consumption and metabolism of essential fatty acids are described as well.The evidence was found both in epidemiological and modeling studies. It supports the participation of EFAs in etiopathogenesis and pathophysiology of schizophrenia. Further research is needed, both observational and interventional, as to the role of essential fatty acids ω-3 in the functioning of the CNS as well as the development and course of schizophrenia.

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Section: The Role Of Efas In the Functioning Of Cnsmentioning

confidence: 99%

“…NNKT ω-3 umożliwiają utrzymanie prawidłowej struktury i integralności błon komórkowych. Oddziaływania te wpływają pośrednio także na struktury związane z membranami (kanały jonowe oraz receptory i transportery) [50,51].…”

Section: Rola Nnkt W Funkcjonowaniu Oununclassified

Omega – 3 fatty acids in schizophrenia – part I: importance in the pathophysiology of schizophrenia

Róg

Karakuła-Juchnowicz

2016

Current Problems of Psychiatry

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“…Omega 3-fatty acids attenuates vascular endothelial dysfunction, by activating eNOS through opening of K + ATP channels in sodium arsenite exposed rats [95]. As mercury is known to modulate eNOS and also K + ATP channels the beneficial effect of habitual consumption of high amounts of fish is associated with better endothelial function despite higher serum concentrations of mercury [96].…”

Section: Omega-3 Unsaturated Fatty Acidmentioning

confidence: 99%

Molecular Basis for Mercury-Induced Alteration in Endothelial Function: NO and its Modulators

Omanwar¹,

Saidullah²

2015

Cardiovasc Pharm Open Access

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Epidemiological and animal studies have suggested a strong association between the environmental and occupational exposure to mercury and risk of cardiovascular diseases (CVD). One of the triggering factors of CVD is endothelial dysfunction. The endothelium can evoke relaxations and contractions of the underlying smooth muscle, by releasing vasoactive agents. Nitric oxide (NO), formed by endothelial NO synthase (eNOS), is the best characterized endothelium derived relaxing factor (EDRF). The release of NO is down regulated/upregulated by factors like oxidative stress, estrogen and diseases like diabetes and hypercholelestrolemia, etc. The inhibition/ activation of eNOS by mercury, affecting the NO release is one of the proposed mechanisms for mercury-induced vascular diseases. In addition, during exposure to mercury, overproduction of reactive oxygen species (ROS) can occur, resulting in oxidative stress, which is another major risk factor for endothelial dysfunction. In this article, molecular basis for mercury-mediated alteration in endothelium derived vasodilator (NO) and factors modulating the release of NO are being reviewed.

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“…Some reagents have been reported to be able to ameliorate Arsenic-mediated endothelial toxicity in vivo . The reagents include linagliptin (a drug for type 2 diabetes) [ 70 ], a combination of telmisartan (an angiotensin receptor blocker used for hypertension) and omega 3-fatty acids [ 71 ], atorvastatin (a statin) [ 72 ], rosiglitazone (a drug for type2 diabetes) [ 73 ], and benfotiamine (a thiamine derivative) [ 74 ]. Further study is needed to address this clinically important issue of arsenic-mediated cardiovascular problems.…”

Section: Introductionmentioning

confidence: 99%

Biological effects and epidemiological consequences of arsenic exposure, and reagents that can ameliorate arsenic damagein vivo

et al. 2017

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Through contaminated diet, water, and other forms of environmental exposure, arsenic affects human health. There are many U.S. and worldwide “hot spots” where the arsenic level in public water exceeds the maximum exposure limit. The biological effects of chronic arsenic exposure include generation of reactive oxygen species (ROS), leading to oxidative stress and DNA damage, epigenetic DNA modification, induction of genomic instability, and inflammation and immunomodulation, all of which can initiate carcinogenesis. High arsenic exposure is epidemiologically associated with skin, lung, bladder, liver, kidney and pancreatic cancer, and cardiovascular, neuronal, and other diseases. This review briefly summarizes the biological effects of arsenic exposure and epidemiological cancer studies worldwide, and provides an overview for emerging rodent-based studies of reagents that can ameliorate the effects of arsenic exposure in vivo. These reagents may be translated to human populations for disease prevention. We propose the importance of developing a biomarker-based precision prevention approach for the health issues associated with arsenic exposure that affects millions of people worldwide.

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Therapeutic interventions using a combination of Telmisartan and omega 3-fatty acids in sodium arsenite-induced vascular endothelial dysfunction in rats: modulation through ATP-sensitive K⁺ channels and eNOS

Abstract: Combined therapy of Telmisartan and omega 3-fatty acids attenuated VED, by activating enzyme nitric oxide synthase (eNOS) through opening of ATP-sensitive K(+) channels.

Cited by 5 publications

References 44 publications

Omega – 3 fatty acids in schizophrenia – part I: importance in the pathophysiology of schizophrenia

Omega – 3 fatty acids in schizophrenia – part I: importance in the pathophysiology of schizophrenia

Molecular Basis for Mercury-Induced Alteration in Endothelial Function: NO and its Modulators

Biological effects and epidemiological consequences of arsenic exposure, and reagents that can ameliorate arsenic damagein vivo

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Therapeutic interventions using a combination of Telmisartan and omega 3-fatty acids in sodium arsenite-induced vascular endothelial dysfunction in rats: modulation through ATP-sensitive K+ channels and eNOS

Abstract: Combined therapy of Telmisartan and omega 3-fatty acids attenuated VED, by activating enzyme nitric oxide synthase (eNOS) through opening of ATP-sensitive K(+) channels.

Cited by 5 publications

References 44 publications

Omega – 3 fatty acids in schizophrenia – part I: importance in the pathophysiology of schizophrenia

Omega – 3 fatty acids in schizophrenia – part I: importance in the pathophysiology of schizophrenia

Molecular Basis for Mercury-Induced Alteration in Endothelial Function: NO and its Modulators

Biological effects and epidemiological consequences of arsenic exposure, and reagents that can ameliorate arsenic damagein vivo

Contact Info

Product

Resources

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Therapeutic interventions using a combination of Telmisartan and omega 3-fatty acids in sodium arsenite-induced vascular endothelial dysfunction in rats: modulation through ATP-sensitive K⁺ channels and eNOS