Therapeutic Keratoplasty for Advanced Suppurative Keratitis

Ti, Seng-Ei; Scott, John A.; Janardhanan, Prathiba; Tan, Donald

doi:10.1016/j.ajo.2007.01.015

Cited by 111 publications

(116 citation statements)

References 34 publications

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“…In the literature, the rate of fungal recurrence is reported to be between 5% and 14%. 27,28 In this study, the recurrence rate was found to be 47.05%, which is higher than the values reported in the literature. 27,28 Preoperative hypopyon, corneal perforation, and corneal infection expanding to the limbus increase the recurrence rate of fungal keratitis after a corneal transplant.…”

Section: Patients Withcontrasting

confidence: 53%

“…In the literature, therapeutic penetrating corneal transplant has been reported to range between 12% and 38% of fungal keratitis. [10][11][12] Nevertheless, this surgery has disadvantages including a high incidence of graft infection and failure. 6,[23][24][25][26] The graft survival rate for therapeutic corneal transplant is related with the type of infective agent, the severity of inflammation, surgical timing, donor tissue quality, graft size, preand postoperative medical treatment, and perforation existence.…”

Section: Patients Withmentioning

confidence: 99%

“…8,9 In the literature, therapeutic corneal transplant has been reported to range in 12% to 38% of fungal keratitis. [10][11][12] Here, we report our clinical results of refractory fungal keratitis patients who underwent therapeutic corneal transplant surgery to save the eye and treat infection.…”

Section: Introductionmentioning

confidence: 99%

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2015

Exp Clin Transplant

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Section: Patients Withcontrasting

confidence: 53%

Section: Patients Withmentioning

confidence: 99%

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2015

Exp Clin Transplant

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“…Реци-дивы инфекции, несмотря на длительное лечение, остаются серьезной проблемой при грибковых кера-титах [54].…”

Section: кератопластикаunclassified

Modern treatments for purulent corneal ulcers

Kasparova¹

2016

Vestn. oftal'mol.

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“…In addition, recurrence of infection remains a significant problem [6,7]. Corneal CXL with UV-A and riboflavin has been used as a new modality in the management of keratoconus to halt the progression of the disease, to prevent visual loss and to postpone the need for surgical intervention.…”

Section: Introductionmentioning

confidence: 99%

Corneal Collagen Cross-linking for Treatment of Bacterial and Herpetic Keratitis

Khalili

Jahadi

Karimi

et al. 2017

JCDR

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Introduction: Optimal management of infective keratitis is a formidable challenge and subject of ongoing studies. Recently, Collagen Cross-Linking (CXL) of the cornea has been considered to be a new effective therapeutic approach for resistant infectious keratitis.Aim: Aim of the study was to evaluate the effectiveness of CXL with Ultraviolet-A (UV-A) and riboflavin for treatment of the refractory bacterial and Herpes Simplex Virus (HSV) keratitis. Materials and Methods:In this prospective interventional study, eight patients with diagnosis of infectious keratitis who were referred to Khalili Hospital eye emergency room, between 2014 and 2015 were included in the study. There were six patients with bacterial keratitis and two patients with HSV keratitis; they were resistant to conventional treatment and underwent CXL. Response to the treatment was considered as good if rapid epithelialization and rapid decrease in stromal infiltration occurred.Results: Microbial culture in the bacterial keratitis group showed coagulase negative Staphylococcus in two patients, Staphylococcus aureus in one patient, mixed infection in one patient and Pseudomonas aeruginosa in two patients. Good response and rapid epithelialization and resolution of stromal infiltration were seen in the four out of six eyes. Two patients showed no response and underwent penetrating keratoplasty for eradication of infection. Furthermore, one patient showed a good response to CXL in the HSV keratitis group and another patient had a relative response but recurrence occurred.Conclusion: Although, CXL seems promising in the treatment of patients with refractory bacterial keratitis, but in some cases, it is ineffective. CXL may be an alternative treatment for refractory cases of HSV keratitis but recurrence is possible.

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Therapeutic Keratoplasty for Advanced Suppurative Keratitis

Cited by 111 publications

References 34 publications

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Modern treatments for purulent corneal ulcers

Corneal Collagen Cross-linking for Treatment of Bacterial and Herpetic Keratitis

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