Therapeutic low energy laser improves the mechanical strength of repairing medial collateral ligament

Fung, Dicky T.C.; Ng, Gabriel Y.F.; Leung, Mason C.P.; Tay, David

doi:10.1002/lsm.10083

Cited by 69 publications

(61 citation statements)

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“…It was then subjected to the failure test at a loading rate of 500 mm/min 24 while the load and displacement data were recorded at a sampling rate of 50 Hz. The load-displacement curve was plotted.…”

Section: Biomechanical Testingmentioning

confidence: 99%

“…Finally, each of the above three values (UTS, stiffness, and load relaxation) of the injured Achilles tendon was normalized against that measured from the contralateral healthy Achilles tendon of the same animal to calculate the percentage of normal strength restored by the injured Achilles tendon at each time point. 24 Histology Bilateral Achilles tendons were harvested from 2 rats from each group for histomorphological study. The medial tendon, including the musculo-tendinous junction, was dissected and fixed in a 4% phosphatebuffered paraformaldehyde solution at room temperature.…”

Section: Biomechanical Testingmentioning

confidence: 99%

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Pulsed ultrasound treatment accelerates the repair of Achilles tendon rupture in rats

Yeung

Guo

2005

Journal Orthopaedic Research

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A rat tenotomy model was used to investigate the effect of combined conservative management and pulsed ultrasound (PUS) on the repair of tenotomized Achilles tendon. Hemitenotomy of right medial Achilles tendon was performed in 48 rats without suture, and patella tenotomy was performed to mimic immobilization and limb disuse of an injured limb. PUS and sham PUS were applied to the healing wound for the treatment group and control group for 5 min, 3 times per week for 2 or 4 weeks, respectively. Tensile tests showed that the ultimate tensile strength (UTS) and stiffness of the repaired tendon in the treatment group at 2 weeks reached 48.92 AE 18.39% and 62.48 AE 32.46% of the contralateral normal tendon strength, which were significantly higher than those of the control group (UTS, 30.36 AE 15.46%; stiffness, 33.90 AE 17.59; p < 0.05). At 4 weeks, UTS increased to 77.09 AE 15.31% and stiffness to 92.48 AE 31.12% in the treatment group, significantly higher than those in the control group (UTS, 54.33 AE 18.40%, p < 0.01; stiffness, 65.02 AE 25.48%, p < 0.05). Light microscopy revealed more regular, denser, and better aligned collagen fibers in the healing scar of the PUS-treated healing tendons. The findings suggested that PUS were able to accelerate the healing of the ruptured tendons. ß

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Section: Biomechanical Testingmentioning

confidence: 99%

Section: Biomechanical Testingmentioning

confidence: 99%

Pulsed ultrasound treatment accelerates the repair of Achilles tendon rupture in rats

Yeung

Guo

2005

Journal Orthopaedic Research

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“…Fung et al (16) avaliaram os efeitos do laser sobre parâmetros biomecânicos, três e seis semanas, na cura de ligamentos colaterais mediais secionados de ratos. Utilizaram logo após a secção do ligamen to o laser de 660nm, em aplicação única com 31,6J/cm 2 ou 63,2J/cm 2 .…”

Section: Introductionunclassified

“…Porém, o uso da terapia laser apresenta controvérsias, devido à grande divergência nos parâmetros dosimétricos e às discrepâncias nos achados (9,(16)(17)(18) . Visto o exposto acima, objetivou-se, no presente estudo, avaliar o uso do laser de baixa potência em dois aspectos do processo de lesão/reparo (dor e edema) de tendão calcâneo de ratos submetidos a trauma experimental.…”

Section: Introductionunclassified

Efeitos do laser de baixa potência sobre a dor e edema no trauma tendíneo de ratos

Bertolini

Silva

Ciena

et al. 2008

Rev Bras Med Esporte

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RESUMOA dor e o edema são sinais, entre outros, que ocorrem durante a fase inflamatória no processo de cura de tendões lesados. A terapia antiinflamatória farmacológica recebe algumas críticas, com relação a seus efeitos deletérios para o reparo. Dessa forma, ganha corpo o uso de recursos físicos para o controle do processo. O objetivo do presente estudo foi avaliar o uso do laser de baixa potência sobre a dor e edema em tendão calcâneo de ratos submetidos a trauma experimental. Foram utilizados 28 ratos Wistar, divididos em quatro grupos: GC -submetido à lesão traumática e ao tratamento placebo; G2 -submetido à lesão e irradiado com laser 2J/cm 2 ; G4 -submetido à lesão e irradiado com 4J/cm 2 ; G8 -submetido à lesão e irradiado com 8J/cm 2 . A lesão foi realizada com a queda de um peso sobre a face lateral do tendão calcâneo direito de cada animal, com energia de aproximadamente 0,40J. A dor foi avaliada pelo tempo de elevação da pata (TEP) do animal caminhando durante um minuto, sobre um cilindro metálico com 30cm de diâmetro em 3rpm; a avaliação do edema ocorreu através de paquimetria; os momentos de avaliação foram: pré-lesão, pós-lesão, pós-tratamento, duas horas, oito horas, 24 horas e 5º dia de lesão. O tratamento com laser 670nm ocorreu de forma pontual e diária. Os resultados mostraram aumentos do TEP e formação de edema em todos os grupos após a lesão; para os grupos tratados houve redução da dor e do edema, fato observado no grupo controle apenas com relação à diminuição de edema no 5º dia de placebo. Conclui-se que o tratamento com laser de baixa potência diminuiu dor e edema nos animais com trauma tendíneo, de forma dose-dependente. Palavras-chave:Tendão do calcâneo, Laser de baixa potência, avaliação da dor. ABSTRACTDuring the injured tendons healing process there is the inflammatory phase, which occurs in the presen ce, among other signs, of pain and edema. The antiinflammatory drug therapy receives some criticism, with respect to its deleterious effects for the repair, thus gain body the use of physical resources for the process control. The aim of this study was to evaluate the use of low level laser therapy on the pain and edema of the rats calcaneus tendon, subjected to experimental trauma. We used 28 rats Wistar, divided into four groups: GC -subjected to traumatic injury and the placebo treatment; G2 -subject to injury and irradiated with laser 2 J/cm 2 ; G4 -subject to injury and irradiated with 4 J/cm 2 ; G8 -submitted to injury and irradiated with 8 J/cm 2 . The lesion was performed with the fall of a weight on the side of the right calcaneus tendon of each animal, with energy of about 0.40 J. The pain was evaluated by the paw elevation time (PET) for a minute, the animal walking on a metal cylinder with 30 cm in diameter at 3 rpm; the edema evaluation occurred through caliper; moments of the evaluation were: after and before injury, before treatment, 2 hours, 8 hours, 24 hours and 5 th injury day. Treatment with laser 670 nm, was so punctual and daily. The results showed increases in PE...

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“…25,28 Despite the intrinsic capacity of spontaneous recovery in injured tendons, 26,27 the process often takes a long time and the qualities of the repaired tendons are inferior to those of intact tendons. 16,20,19,31,32 To restore the optimal function of injured tendons it is important to develop therapeutic interventions that facilitate the process of healing.Low-voltage microamperage stimulation (LVMAS), characterized as an electrical stimulation with very low current, is advocated to promote tissue healing. It is theorized that healthy tissue is the result of the direct flow of electrical current throughout the body.…”

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confidence: 99%

Effects of Low-Voltage Microamperage Stimulation on Tendon Healing in Rats

Chan

Fung²,

Ng³

2007

J Orthop Sports Phys Ther

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a chilles tendon ruptures are common in athletes and the middle-aged, and there have been increasing reports of Achilles tendon ruptures in recent decades. 25,28 Despite the intrinsic capacity of spontaneous recovery in injured tendons, 26,27 the process often takes a long time and the qualities of the repaired tendons are inferior to those of intact tendons. 16,20,19,31,32 To restore the optimal function of injured tendons it is important to develop therapeutic interventions that facilitate the process of healing. Low-voltage microamperage stimulation (LVMAS), characterized as an electrical stimulation with very low current, is advocated to promote tissue healing. It is theorized that healthy tissue is the result of the direct flow of electrical current throughout the body. 6,40,39 It is the opinion of Becker and Sheldon 7 that when the body is injured, the electrical balance is disrupted in that particular region, causing the electrical current to change course. The use of LVMAS over the injured site is thought to realign this t STuDy DeSign: Randomized controlled prospective experimental study. t ObjeCTiveS: To examine the effects of trans-cutaneous low-voltage microamperage stimulation (LVMAS) on the mechanical strength of Achilles tendon repair in rats at 4 weeks after injury. t baCKgrOunD: Understanding the effect of LVMAS on the healing of injured tendons is hampered by the lack of related experimental studies , especially from the aspect of biomechanical outcome measures. t MeTHODS anD MeaSureS: Fourteen 3-month-old male Sprague-Dawley rats received surgical transection to the medial portion of their right Achilles tendon. The rats were divided into a LVMAS group (n = 7) and control group (n = 7). From day 6 postsurgery onwards, the LVMAS group received daily treatment of transcutaneous LVMAS (2.5 V, 100 μA/cm 2 , 10 pulses per second, positive current) for a total of 22 sessions, while the control group received placebo LVMAS by the same investigator during that period. On day 31, the Achilles tendons were harvested for biomechanical testing for load relaxation, stiffness, and ultimate tensile strength along the longitudinal direction. t reSulTS: The normalized Achilles tendon ultimate tensile strength of the LVMAS group (mean 6 SD, 110.5% 6 25.0%) was higher than that of the control group (75.3% 6 20.8%) (P = .014), but no significant difference was found in normalized stiffness and load relaxation between the 2 groups (P = .239 and .350, respectively). t COnCluSiOn: The results of this study suggest that the administration of transcutane-ous LVMAS could improve healing and consequently the tensile strength of partially transected Achilles tendons of rats at 4 weeks after injury.

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Therapeutic low energy laser improves the mechanical strength of repairing medial collateral ligament

Abstract: A single dose of low energy laser therapy improves the UTS and stiffness of repairing MCL at 3 and 6 weeks after injury.

Cited by 69 publications

References 30 publications

Pulsed ultrasound treatment accelerates the repair of Achilles tendon rupture in rats

Pulsed ultrasound treatment accelerates the repair of Achilles tendon rupture in rats

Efeitos do laser de baixa potência sobre a dor e edema no trauma tendíneo de ratos

Effects of Low-Voltage Microamperage Stimulation on Tendon Healing in Rats

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