Therapeutic Microemulsion of Curcumin for the Management of Osteoarthritis

Sharma, Shreyasi; Ganju, Eisha; Upmanyu, Neeraj; Jain, Prabhat

doi:10.22270/jddt.v8i5-s.1989

Cited by 5 publications

(9 citation statements)

References 22 publications

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“…Based on the previously determined calibration curve, the maximum amount of Curcumin that can be solubilized in LVM microemulsion and gel microemulsions was identified ( Figure 4 ). The maximum Curcumin capacity that could be encapsulated in the LVM microemulsion (1.69 wt.%, Figure 4 ) was approximately 2-fold higher than in the microemulsion prepared with oleic acid, Smix (ethanol and Tween 80, Span 80, n-butanol) and water, as described by S. Sharma et al [ 43 ]. In the case of gel microemulsions, there was generally a very small increase in the incorporation capacity of Curcumin ( Figure 4 ) compared to simple microemulsion, probably due to the interaction between drug molecules and polyelectrolyte chains.…”

Section: Resultsmentioning

confidence: 54%

Novel Gel Microemulsion as Topical Drug Delivery System for Curcumin in Dermatocosmetics

et al. 2021

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Gel microemulsion combines the advantages of the microemulsion, which can encapsulate, protect and deliver large quantities of active ingredients, and the gel, which is so appreciated in the cosmetic industry. This study aimed to develop and characterize new gel microemulsions suitable for topical cosmetic applications, using grape seed oil as the oily phase, which is often employed in pharmaceuticals, especially in cosmetics. The optimized microemulsion was formulated using Tween 80 and Plurol® Diisostearique CG as a surfactant mix and ethanol as a co-solvent. Three different water-soluble polymers were selected in order to increase the viscosity of the microemulsion: Carbopol® 980 NF, chitosan, and sodium hyaluronate salt. All used ingredients are safe, biocompatible and biodegradable. Curcumin was chosen as a model drug. The obtained systems were physico-chemically characterized by means of electrical conductivity, dynamic light scattering, polarized microscopy and rheometric measurements. Evaluation of the cytotoxicity was accomplished by MTT assay. In the final phase of the study, the release behavior of Curcumin from the optimized microemulsion and two gel microemulsions was evaluated. Additionally, mathematical models were applied to establish the kinetic release mechanism. The obtained gel microemulsions could be effective systems for incorporation and controlled release of the hydrophobic active ingredients.

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Section: Resultsmentioning

confidence: 54%

Novel Gel Microemulsion as Topical Drug Delivery System for Curcumin in Dermatocosmetics

et al. 2021

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“…The curcumin microemulsion encapsulating performance was 88 ± 1.5%. Sharma et al reported an EE of 69.98 ± 0.21 to 83.32 ± 0.15% for curcumin-loaded Pluronic F-127 microemulsions [ 83 ]. Chen et al prepared curcuminoid microemulsions consisting of soybean oil, Tween 80, ethanol, and water with an EE of 85.7% [ 84 ].…”

Section: Resultsmentioning

confidence: 99%

“…This is a significant achievement potentially enabling a prolonged therapeutic effect. In a previous study, Sharma et al reported that curcumin release of about 74% in 8 h for optimized microemulsion formulations [ 83 ].…”

Section: Resultsmentioning

confidence: 99%

Biochemical, Ameliorative and Cytotoxic Effects of Newly Synthesized Curcumin Microemulsions: Evidence from In Vitro and In Vivo Studies

et al. 2021

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Curcumin is known to exhibit antioxidant and tissue-healing properties and has recently attracted the attention of the biomedical community for potential use in advanced therapies. This work reports the formulation and characterization of oil-in-water F127 microemulsions to enhance the bioavailability of curcumin Microemulsions showed a high encapsulation efficiency and prolonged release. To investigate the interactions of curcumin with one unit of the polymeric chain of surfactant F127, ethyl butyrate, and sodium octanoate, as well as the interaction between ethyl butyrate and one unit of the F127 polymer chain, the Density Functional Theory (DFT) calculations at the M06-2X level of theory, were performed in water solution. The MTT assay was used to assess the cytotoxicity of free and encapsulated curcumin on non-malignant and malignant cell lines. Combination effects were calculated according to Chou-Talalay’s principles. Results of in vitro studies indicated that MCF7 and HepG2 cells were more sensitive to curcumin microemulsions. Moreover, a synergistic relationship was observed between curcumin microemulsions and cisplatin in all affected fractions of MCF7 and HepG2 cells (CI < 0.9). For in vivo investigation, thioacetamide-intoxicated rats received thioacetamide (100 mg/kg Sc) followed by curcumin microemulsions (30 mg/kg Ip). Thioacetamide-intoxicated rats showed elevated serum liver enzymes, blood urea nitrogen (BUN), and creatinine levels, and a significant reduction in liver superoxide dismutase (SOD) and catalase (CAT) activities (p < 0.05). Curcumin microemulsions reduced liver enzymes and serum creatinine and increased the activity of antioxidant enzymes in thioacetamide-treated rats in comparison to the untreated thioacetamide-intoxicated group. Histopathological investigations confirmed the biochemical findings. Overall, the current results showed the desirable hepatoprotective, nephroprotective, and anti-cancer effects of curcumin microemulsions.

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“…The microemulsion sample subjected to-20 ᵒC for 24 h and then another 24h at 40 ᵒC . The physical stability of microemulsion was examined by measuring globule size and polydispersity index before and after the freeze-thaw cycle and centrifugation [19].…”

Section: Freeze-thaw Cyclementioning

confidence: 99%

“…The average globule size, polydispersity index, and zeta potential of the curcumin-loaded emulgel were determined by dispersed gel into distilled water, and kept for sonication (20-30 s) and after that for vortexed for 1 min to make sure that to minimize the aggregation if present in microemulsion gel [19]. After that, the sample was analyzed for average globule size, polydispersity index, and zeta potential by using Zetasizer (Nano ZS: Malvern Instruments.…”

Section: Globule Size and Polydispersity Index And Zeta Potential Analysismentioning

confidence: 99%

Formulation and Development of Curcumin Based Emulgel in Treatment and Recurrence of Vaginal Candidiasis

Bairagi

Patel

2021

Int J Curr Pharm Sci

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Objective: The main causative agent of vaginal candidiasis is Candida albicans and it develops resistance against several synthetic antifungal drugs and it has a high rate of infection in women. According to WHO report, around 75% of women are infected by Candida albicans and 50 % are infected a second time by Candida albicans. Therefore, we choose Curcumin an antifungal agent that had reported antifungal properties against the various fungal species. The Curcumin-containing emulgel based microemulsion system was prepared for greater retention time and penetration across the vaginal mucosa. Methods: The screening of oil phase, surfactant, and cosurfactant for microemulsion formulation was selected based on the solubility study and followed by the construction of the pseudoternary phase diagram. The oil phase, surfactant and co-surfactant are selected from the pseudoternary phase diagram for the formulation of a stable microemulsion. The prepared Curcumin-loaded microemulsion was characterized by globule size, polydispersity index, Zeta potential, accelerated stability study, drug content, percent transmittance and antifungal assay by broth microdilution technique. The formulated microemulsion was converted into a vaginal emulgel by using Pluronic@F127. The formulated curcumin-loaded emulgel was characterized by different evaluation parameters and antifungal study by agar well diffusion method. Results: The result showed that the average globule size of emulgel was 286.3 nm, polydispersity index was 0.241, Zeta potential was+19.20 mv, conductivity was 0.0390 mS/cm, and drug content was found to be 95.58%. The texture of formulated emulgel was found to be soft and smooth, with shear-thinning, pseudoplastic behavior, and easily spreadable. The in vitro permeability study of emulgel shows slow and complete release of curcumin in 10 h. The microemulsion and developed emulgel showed promising antifungal activity against Candida albicans. Conclusion: The developed curcumin-loaded emulgel showed promising antifungal activity against Candida albicans as compared to the Fluconazole as an standard antifungal antibiotic. Our formulated Curcumin-containing emulgel can be a potential alternative as compared to the conventional dosage form for the treatment of vaginal candidiasis.

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Therapeutic Microemulsion of Curcumin for the Management of Osteoarthritis

Cited by 5 publications

References 22 publications

Novel Gel Microemulsion as Topical Drug Delivery System for Curcumin in Dermatocosmetics

Novel Gel Microemulsion as Topical Drug Delivery System for Curcumin in Dermatocosmetics

Biochemical, Ameliorative and Cytotoxic Effects of Newly Synthesized Curcumin Microemulsions: Evidence from In Vitro and In Vivo Studies

Formulation and Development of Curcumin Based Emulgel in Treatment and Recurrence of Vaginal Candidiasis

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