Therapeutic modalities in thrombotic thrombocytopenic purpura management among Jehovah’s Witness patients: A review of reported cases

Tran, Minh‐Ha

doi:10.1016/j.transci.2023.103706

Cited by 2 publications

(3 citation statements)

References 38 publications

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“…First-line treatment of autoimmune TTP includes prompt initiation of therapeutic plasma exchange (TPE), steroids, and rituximab. A newer agent, caplacizumab, is now approved for use in conjunction with TPE for treatment of TTP [38,39].…”

Section: 33mentioning

confidence: 99%

Thrombotic microangiopathy – the importance of a multidisciplinary approach

Tran,

Patel,

Desai

et al. 2023

Current Opinion in Nephrology &Amp; Hypertension

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Purpose of review The purpose of this review is to highlight the importance of a multidisciplinary thrombotic microangiopathies (TMA) Team. This goal will be accomplished through review of the complement system, discuss various causes of thrombotic microangiopathies (TMA), and aspects of their diagnosis and management. In so doing, readers will gain an appreciation for the complexity of this family of disorders and realize the benefit of a dedicated multidisciplinary TMA Team. Recent findings TMA causes derive from multiple specialty areas, are difficult to timely recognize, pose complex challenges, and require multidisciplinary management. Hematopoietic stem cell transplant-associated TMA (TA-TMA) and TA-TMA related multiorgan dysfunction syndrome (TA-TMA MODS) are areas of burgeoning research; use of complement testing and eculizumab precision-dosing has been found to better suppress complement activity in TA-TMA than standard eculizumab dosing. Newer tests are available to risk-stratify obstetric patients at risk for severe pre-eclampsia, whose features resemble those of TA-TMA MODS. Numerous disorders may produce TMA-like findings, and a systematic approach aids in their identification. TMA Teams elevate institutional awareness of increasingly recognized TMAs, will help expedite diagnostic and therapeutic interventions, and create pathways to future TMA-related research and facilitate access to clinical trials. Summary Establishment of a TMA-Team is valuable in developing the necessary institutional expertise needed to promptly recognize and appropriately manage patients with TMA.

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Section: 33mentioning

confidence: 99%

Thrombotic microangiopathy – the importance of a multidisciplinary approach

Tran,

Patel,

Desai

et al. 2023

Current Opinion in Nephrology &Amp; Hypertension

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show abstract

“…Instead, TPE can be conducted with an accepted media, such as albumin, and supplementation of deficient ADAMTS13 accomplished using ADAMTS13‐enriched plasma fractions, provided they are acceptable to the individual patient. Reported fractions utilized in this circumstance include cryoprecipitate, cryo‐poor plasma, Koate‐DVI, and Alphanate 52 …”

Section: Evolving Landscape Of Therapeutic Apheresis and Cellular The...mentioning

confidence: 99%

“…To reduce inhibitor levels, hasten remission, and prevent relapse, rituximab (Genentech, South San Francisco, CA) has entered standard practice for management of TTP 52 . More recently, caplacizumab (Genzyme, Cambridge MA, USA), an anti‐VWF humanized single‐variable‐domain immunoglobulin available for management of iTTP, 53–55 received FDA approval in December of 2019 for the treatment of iTTP in conjunction with TPE.…”

Section: Evolving Landscape Of Therapeutic Apheresis and Cellular The...mentioning

confidence: 99%

Historic and emerging trends in transfusion medicine: Maintaining relevance as a specialty

Tran,

Mathur,

Barnhard

et al. 2023

Transfusion

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Therapeutic modalities in thrombotic thrombocytopenic purpura management among Jehovah’s Witness patients: A review of reported cases

Cited by 2 publications

References 38 publications

Thrombotic microangiopathy – the importance of a multidisciplinary approach

Thrombotic microangiopathy – the importance of a multidisciplinary approach

Historic and emerging trends in transfusion medicine: Maintaining relevance as a specialty

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