Therapeutic nanovaccines sensitize EBV-associated tumors to checkpoint blockade therapy

Liu, Hong; Chen, Haolin; Liu, Zhijia; Le, Zhicheng; Nie, Tianqi; Qiao, Dongdong; Su, Yan; Mai, Hai‐Qiang; Chen, Yongming; Liu, Lixin

doi:10.1016/j.biomaterials.2020.120158

Cited by 42 publications

(21 citation statements)

References 39 publications

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“…This induces effective inhibition of oncogenesis. In studies on mice, it has been shown that the application of the agent also results in a decrease in the tumor and an increase in the lifespan of the rodents [50].…”

Section: Epstein-barr Virusmentioning

confidence: 99%

Antiviral Properties of Polyphenols from Plants

Chojnacka

Skrzypczak

Izydorczyk

et al. 2021

Foods

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Polyphenols are active substances against various types of viral infections. Researchers have characterized methods of how to isolate polyphenols without losing their potential to formulate pharmaceutical products. Researchers have also described mechanisms against common viral infections (i.e., influenza, herpes, hepatitis, rotavirus, coronavirus). Particular compounds have been discussed together with the plants in the biomass in which they occur. Quercetin, gallic acid and epigallocatechin are exemplary compounds that inhibit the growth cycle of viruses. Special attention has been paid to identify plants and polyphenols that can be efficient against coronavirus infections. It has been proven that polyphenols present in the diet and in pharmaceuticals protect us from viral infections and, in case of infection, support the healing process by various mechanisms, i.e., they block the entry into the host cells, inhibit the multiplication of the virus, seal blood vessels and protect against superinfection.

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Section: Epstein-barr Virusmentioning

confidence: 99%

Antiviral Properties of Polyphenols from Plants

Chojnacka

Skrzypczak

Izydorczyk

et al. 2021

Foods

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show abstract

“…What's more, the obtained nanovaccines could accurately target the LNs, induced strong immune stimulation, and reshaped the TME to break the tumor immune tolerance, which was promising to be used in the future for the effective treatment of clinical patients with EBVs positive tumors. 106 The above-enumerated CpG-based nanovaccines for cancer immunotherapy were summarized in Table 2. These CpG-based nanovaccines were described according to the following information: loading technique, selected CpG type, used antigen, tumor type, therapeutic effect, and studied in vitro or in vivo.…”

Section: Cpg Loaded In Nanovaccines Through Other Methodsmentioning

confidence: 99%

“…It is hoped that this review will provide valuable references for the development of nanovaccines in cancer immunotherapy. Both [106]…”

mentioning

confidence: 99%

CpG-Based Nanovaccines for Cancer Immunotherapy

Chen¹,

Jiang²,

Yu³

et al. 2021

IJN

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Cancer has been a serious health hazard to the people all over the world with its high incidence and horrible mortality. In recent years, tumor vaccines in immunotherapy have become a hotspot in cancer therapy due to their many practical advantages and good therapeutic potentials. Among the various vaccines, nanovaccine utilized nanoparticles (NPs) as the carrier and/or adjuvant has presented significant therapeutic effect in cancer treatment. For tumor nanovaccines, unmethylated cytosine-phosphate-guanine oligodeoxynucleotide (CpG ODN) is a commonly used adjuvant. It has been reported that CpG ODN was the most effective immune stimulant among the currently known adjuvants. It could be recognized by toll-like receptor 9 (TLR9) to activate humoral and cellular immunity for preventing or treating cancer. In this review, the topic of CpG-based nanovaccines for cancer immunotherapy will be focused. The types and properties of different CpG will be introduced in detail first, and then some representative tumor nanovaccines will be reviewed according to the diverse loading modes of CpG, such as electrostatic adsorption, covalent bonding, hydrophilic and hydrophobic interaction, and DNA self-assembly, for summarizing the current progress of CpG-based tumor nanovaccines. Finally, the challenges and future perspectives will be discussed. It is hoped that this review will provide valuable references for the development of nanovaccines in cancer immunotherapy.

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“…The intracellular staining was conducted as previously described. 30 Neutralizing Assay. The sera from different groups of mice were collected, and they were inactivated at 56 °C for 0.5 h. After two-fold dilution with the complete medium, they were incubated with 100 TCID 50 of SARS-CoV-2 virus in an incubator for 2 h at a ratio of 1:1.…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Subunit Nanovaccine with Potent Cellular and Mucosal Immunity for COVID-19

Liu

Chen

et al. 2020

ACS Appl. Bio Mater.

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To combat the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, we formulated the S1 subunit of the virus with two adjuvants, amphiphilic adjuvant monophosphoryl lipid A for Toll-like receptor 4 and CpG oligodeoxynucleotide for Toll-like receptor 9, into cationic liposomes to produce a potent, safer, and translatable nanovaccine. The nanovaccine can efficiently elicit a humoral immune response and strong IgA antibodies in mice. The sera from the vaccinated mice significantly inhibit SARS-CoV-2 from infecting Vero cells. Moreover, relative to the free S1 with a traditional Alum adjuvant, the nanovaccine can elicit strong T-cell immunity by activating both CD4 + and CD8 + cells.

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Therapeutic nanovaccines sensitize EBV-associated tumors to checkpoint blockade therapy

Cited by 42 publications

References 39 publications

Antiviral Properties of Polyphenols from Plants

Antiviral Properties of Polyphenols from Plants

CpG-Based Nanovaccines for Cancer Immunotherapy

Subunit Nanovaccine with Potent Cellular and Mucosal Immunity for COVID-19

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