Therapeutic Opportunities for Food Supplements in Neurodegenerative Disease and Depression

Businaro, Rita; Vauzour, David; Sarris, Jerome; Münch, Gerald; Gyengési, Erika; Brogelli, Laura; Zuzarte, Pedro

doi:10.3389/fnut.2021.669846

Cited by 29 publications

(18 citation statements)

References 108 publications

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“…Collaborating with statins findings, some authors suggest that continuous supplemental nutrition, for example with antioxidants or long-chain polyunsaturated fatty acids, could prevent neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and dementias (revised by Businaro et al, 2021).…”

Section: Drug Strategy-where Are Wementioning

confidence: 99%

Systemic Response to Infection Induces Long-Term Cognitive Decline: Neuroinflammation and Oxidative Stress as Therapeutical Targets

Reis

Castro‐Faria‐Neto

2022

Front. Neurosci.

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In response to pathogens or damage signs, the immune system is activated in order to eliminate the noxious stimuli. The inflammatory response to infectious diseases induces systemic events, including cytokine storm phenomenon, vascular dysfunction, and coagulopathy, that can lead to multiple-organ dysfunction. The central nervous system (CNS) is one of the major organs affected, and symptoms such as sickness behavior (depression and fever, among others), or even delirium, can be observed due to activation of endothelial and glial cells, leading to neuroinflammation. Several reports have been shown that, due to CNS alterations caused by neuroinflammation, some sequels can be developed in special cognitive decline. There is still no any treatment to avoid cognitive impairment, especially those developed due to systemic infectious diseases, but preclinical and clinical trials have pointed out controlling neuroinflammatory events to avoid the development of this sequel. In this minireview, we point to the possible mechanisms that triggers long-term cognitive decline, proposing the acute neuroinflammatory events as a potential therapeutical target to treat this sequel that has been associated to several infectious diseases, such as malaria, sepsis, and, more recently, the new SARS-Cov2 infection.

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Section: Drug Strategy-where Are Wementioning

confidence: 99%

Systemic Response to Infection Induces Long-Term Cognitive Decline: Neuroinflammation and Oxidative Stress as Therapeutical Targets

Reis

Castro‐Faria‐Neto

2022

Front. Neurosci.

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“…Changes that occur with age can impact homeostatic functions in cells, rendering them sensitive to neurodegeneration. Other external factors, such as diet and exercise, are proving to be crucial factors in maintaining CNS health [ 39 , 40 ]. Micronutrients, such as vitamins and trace elements are integral to many key biological processes, such as mitochondrial ATP production and immune responses, which in turn affect CNS physiology [ 39 ].…”

Section: Main Textmentioning

confidence: 99%

“…Other external factors, such as diet and exercise, are proving to be crucial factors in maintaining CNS health [ 39 , 40 ]. Micronutrients, such as vitamins and trace elements are integral to many key biological processes, such as mitochondrial ATP production and immune responses, which in turn affect CNS physiology [ 39 ]. Recognizing the role that external factors play in degeneration and the impact on cellular mechanisms as outlined blow (i.e., signaling pathways such as neuroinflammation, metabolism, mitochondrial dysfunction), will help to provide novel therapeutic strategies for neurodegenerative diseases.…”

Section: Main Textmentioning

confidence: 99%

Solving neurodegeneration: common mechanisms and strategies for new treatments

Wareham

Liddelow²,

Temple

et al. 2022

Mol Neurodegeneration

154

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Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology or site of disease pathology. To address these mechanisms and discuss emerging treatments, in April, 2021, Glaucoma Research Foundation, BrightFocus Foundation, and the Melza M. and Frank Theodore Barr Foundation collaborated to bring together key opinion leaders and experts in the field of neurodegenerative disease for a virtual meeting titled “Solving Neurodegeneration”. This “think-tank” style meeting focused on uncovering common mechanistic roots of neurodegenerative disease and promising targets for new treatments, catalyzed by the goal of finding new treatments for glaucoma, the world’s leading cause of irreversible blindness and the common interest of the three hosting foundations. Glaucoma, which causes vision loss through degeneration of the optic nerve, likely shares early cellular and molecular events with other neurodegenerative diseases of the central nervous system. Here we discuss major areas of mechanistic overlap between neurodegenerative diseases of the central nervous system: neuroinflammation, bioenergetics and metabolism, genetic contributions, and neurovascular interactions. We summarize important discussion points with emphasis on the research areas that are most innovative and promising in the treatment of neurodegeneration yet require further development. The research that is highlighted provides unique opportunities for collaboration that will lead to efforts in preventing neurodegeneration and ultimately vision loss.

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“…1 Alterations in energy expenditure balance disrupt the crosstalk between metabolism and immune system, causing the activation of an immune response and the development of a systemic inflammation with a low-grade, which is one of the main risk factors for the development of depression as well as cognitive impairment. 2 According to Straub et al, 3 neuroendocrine pathways are implicated in the regulation of energy: inflammation induces higher levels of cortisol in the serum, by stimulating the hypothalamicpituitary-adrenal axis (HPA) and the sympathetic nervous system (SNS), leading to a sickness behavior, with a marked reduction of gut, muscle and brain activity. The elevated levels of proinflammatory cytokines observed in systemic inflammation target brain cells binding to specific cytokine receptors expressed on glial cells and neurons thereby directly affecting the brain function, increasing the risk to develop depression.…”

Section: Introductionmentioning

confidence: 99%

Food supplements to complement brain functioning: the benefits of a combination of magnesium, folic acid, omega-3 fatty acids and vitamin E

Businaro

2022

F1000Res

Self Cite

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Diet and nutrition play a fundamental role not only in human body composition and in physiology, but have also relevant effects on mood, mental well-being and cognitive performance. In particular, the preservation of mental well-being through a healthy lifestyle, including a well-balanced diet and, in case, through the intake of specific food supplements, is of particular relevance in the perspective of global human ageing, as the brain is affected significantly by a persistent presence of stress factors. Due to the increasing burden of mental and neurological disorders and to the universality of food as a modifiable risk factor, even limited improvements in nutritional habits may translate to a considerable rise of well-being and mental health in the global population. Moreover, the use of targeted, well-balanced food supplements aiming to support the mental health and well-being will probably represent a relevant tool in future decades, together with an increased awareness of the importance of nutrition, also considering the COVID-19 pandemic and the related stressful events and limitations we are still experiencing at global level. The aim of this review is to summarize the experimental and clinical data reported in the literature concerning the beneficial effects of a subset of micro- and macronutrients contained both in food and in supplements, namely magnesium, folic acid, docosahexaenoic acid, eicosapentaenoic acid, and alpha-tocopherol, on a series of disorders, including stress, anxiety, low sleep quality, and low cognitive performance.

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Therapeutic Opportunities for Food Supplements in Neurodegenerative Disease and Depression

Cited by 29 publications

References 108 publications

Systemic Response to Infection Induces Long-Term Cognitive Decline: Neuroinflammation and Oxidative Stress as Therapeutical Targets

Systemic Response to Infection Induces Long-Term Cognitive Decline: Neuroinflammation and Oxidative Stress as Therapeutical Targets

Solving neurodegeneration: common mechanisms and strategies for new treatments

Food supplements to complement brain functioning: the benefits of a combination of magnesium, folic acid, omega-3 fatty acids and vitamin E

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