Therapeutic Options for Melatonin Use in Children

Wassmer, Evangeline; Ross, Carol; Whitehouse, William

doi:10.1185/1463009001505240

Cited by 6 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study both children receiving melatonin and those who were sleep deprived obtained sleep in about 70%, corroborating previous studies (Johnson et al, 2002;Wassmer et al, 2000Wassmer et al, , 2001b. The effect of melatonin as a sleep inducer for EEG in children between 1 and 16 years of age as a whole group have been described, however, without specific notion to age subgroups (Eisermann et al, 2010;Sander et al, 2012;Wassmer et al, 2001b).…”

Section: Discussionsupporting

confidence: 93%

Occurrence of epileptiform discharges and sleep during EEG recordings in children after melatonin intake versus sleep-deprivation

Gustafsson

Broström

Ulander

et al. 2015

Clinical Neurophysiology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 93%

Occurrence of epileptiform discharges and sleep during EEG recordings in children after melatonin intake versus sleep-deprivation

Gustafsson

Broström

Ulander

et al. 2015

Clinical Neurophysiology

View full text Add to dashboard Cite

“…It resulted in successful sleep in 84.9% of our patients. This result is consistent with a study reported by Wassmer et al (2000), which described that melatonin may be used in children to induce sleep during EEG recordings effectively [11].…”

Section: Discussionsupporting

confidence: 93%

“…Melatonin offers a safe alternative for sleep induction instead of the currently used methods. Melatonin is an endogenous hormone produced in the pineal gland that is secreted in the dark to help regulate the body's natural sleep/wake cycle [11]. An exogenous form of the drug has been used to induce natural sleep for different procedures including EEG procedures and magnetic resonance imaging (MRI) [12].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Melatonin as a Sleep Inducer in EEG Procedures in the Pediatric Population: A Cross-Sectional Study

Tahir,

Flynn,

Babiker

2024

Cureus

View full text Add to dashboard Cite

IntroductionMelatonin has been used as an alternative to sleep deprivation for EEG sleep induction in the pediatric population. Our study aims to describe the efficacy of the currently used doses of melatonin for sleep induction among the pediatric age group. MethodsA retrospective cross-sectional study included all patients who underwent an EEG after receiving melatonin over the period of one year. A total of 126 patients have been included in the study. Patients aged one year to three years received oral melatonin in doses between 2 mg and 6 mg. Patients in the age of three years and above received 10 mg of melatonin. Patients' success rate in achieving sleep and the exact time required for the patients to fall asleep were obtained using the readings of their EEG. The percentage of patients who have achieved sleep and the time required for those patients to sleep were calculated and correlated with the patient's gender, the presence of any associated neurobehavioral disorders, and their use of antiepileptic drugs (AED). ResultsSuccessful sleep was achieved in 84.9% (n:107) of the patients, with a mean time of 24 minutes to fall asleep (SD = 14.36). Patients with neurobehavioral disorders were 20% less likely to fall asleep when compared to other patients without neurobehavioral disorders (p: 0.003). However, there was not a statistically significant difference among different genders and among patients who received AED. ConclusionMelatonin is an effective sleep inducer for patients undergoing EEG procedures. It should be considered in the majority of patients. However, in patients with neurobehavioral disorders, a lower success rate is expected.

show abstract

“…Studies have shown melatonin can lack effectiveness depending on the circumstances relating to when it is taken, dose, if it a quick or slow release formula, and on some clinical disorders. Numerous studies have also highlighted the use of melatonin in paediatric sleepwake cycle disorders and AD's, [83] however there have been no RCTs or long term studies showing evidence for its therapeutic use in this age group.…”

mentioning

confidence: 99%

Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders

Auld

Maschauer

Morrison

et al. 2017

Sleep Medicine Reviews

334

142

View full text Add to dashboard Cite

Melatonin is a physiological hormone involved in sleep timing and is currently used exogenously in the treatment of primary and secondary sleep disorders with empirical evidence of efficacy, but very little evidence from randomised, controlled studies. The aim of this meta-analysis was to assess the evidence base for the therapeutic effects of exogenous melatonin in treating primary sleep disorders. An electronic literature review search of MEDLINE (1950-present) EMBASE (1980- present), PsycINFO (1987- present), and SCOPUS (1990- present), along with a hand-searching of key journals was performed in July 2013 and then again in May 2015. This identified all studies that compared the effect of exogenous melatonin and placebo in patients with primary insomnia, delayed sleep phase syndrome, Non 24- hour sleep wake syndrome in people who are blind, and REM-Behaviour Disorder. Meta-analyses were performed to determine the effect of magnitude in studies of melatonin in improving sleep. A total of 5030 studies were identified; of these citations, 13 were included for review based on the inclusion criteria of being: double or single-blind, randomised and controlled. Results from the meta-analyses showed the most convincing evidence for exogenous melatonin use was in reducing sleep onset latency in primary insomnia (p=0.002), delayed sleep phase syndrome (p<0.0001), and regulating the sleepwake patterns in blind patients compared with placebo. These findings highlight the potential importance of melatonin in treating certain first degree sleep disorders. The development of large-scale, randomised, controlled trials is recommended to provide further evidence for therapeutic use of melatonin in a variety of sleep difficulties

show abstract

Therapeutic Options for Melatonin Use in Children

Cited by 6 publications

References 0 publications

Occurrence of epileptiform discharges and sleep during EEG recordings in children after melatonin intake versus sleep-deprivation

Occurrence of epileptiform discharges and sleep during EEG recordings in children after melatonin intake versus sleep-deprivation

Efficacy of Melatonin as a Sleep Inducer in EEG Procedures in the Pediatric Population: A Cross-Sectional Study

Evidence for the efficacy of melatonin in the treatment of primary adult sleep disorders

Contact Info

Product

Resources

About