Therapeutic Options in the Treatment of Nighttime Gastroesophageal Reflux

Orr, William C.

doi:10.1159/000089957

Cited by 20 publications

(13 citation statements)

References 92 publications

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“…Gastroesophageal reflux is a physiological phenomenon and gastric contents entering the oesophagus are cleared by a combination of peristalsis, which removes the bulk of the fluid, followed by neutralization of any acid by saliva [26]. A certain number of gastroesophageal reflux episodes are within the physiological range of normality but GERD is a pathological condition [27].…”

Section: Gastroesophageal Reflux Diseasementioning

confidence: 99%

Intrinsic Causes of Erosion

Moazzez

Bartlett²

2014

Monographs in Oral Science

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Gastric juice entering the mouth causes dental erosion. Common causes for the migration of gastric juice through the lower and upper oesophageal sphincters are reflux disease, laryngopharyngeal reflux, eating disorders, chronic alcoholism and pregnancy. Gastroesophageal reflux is a common condition affecting up to 65% of the Western population at some point in their lifetime. A typical clinical sign of acidic gastric juice entering the mouth is palatal dental erosion. As the condition becomes more chronic it becomes more widespread. There have been relatively few randomised studies investigating the aetiology of acids causing erosion. Of the few that have reported their findings, it appears that gastric acids have the potential to induce moderate-to-severe erosion. This literature review reports the conditions associated with the movement of gastric juice and dental erosion using medical and dental sources.

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Section: Gastroesophageal Reflux Diseasementioning

confidence: 99%

Intrinsic Causes of Erosion

Moazzez

Bartlett²

2014

Monographs in Oral Science

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“…In GERD patients with hypertension, lifestyle corrections for the treatment of hypertension can have positive effects on GERD, helping hypertensive GERD patients to respond to therapy. Similarly, a correlation between sleep disorders and GERD has been suggested [20,21], and one study documented that insomnia exacerbates GERD symptoms [22]. Based on the results of the present study, it is not clear if insomnia causes GERD or vice versa, but the results suggest that GERD patients with insomnia complications may be less likely to respond to conventional PPI doses for GERD.…”

Section: Discussionmentioning

confidence: 46%

Response to Gastroesophageal Reflux Disease Therapy: Assessment at 4 Weeks Predicts Response/Non-Response at 8 Weeks

Kusano

Hongo²,

Miwa³

2012

Digestion

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Background: Many questionnaires that assess subjective symptoms or health-related quality of life (HRQOL) have been developed to confirm the efficacy of treatment in patients with gastroesophageal reflux disease (GERD). However, few reports have correlated early improvements in scale scores with predictions of subsequent therapeutic responses. Our aim was to investigate the appropriate timing for evaluating therapeutic response and subsequent changes in symptoms and HRQOL. Methods: This was a post hoc analysis of a multicenter prospective cohort study. A total of 5,279 GERD patients with Frequency Scale for the Symptoms of GERD (FSSG) scores ≥8 points at baseline were analyzed. Correlations between HRQOL and FSSG were investigated and logistic regression analysis was performed. Results: The FSSG scores and HRQOL improvements in responders were significantly greater than in non-responders. Positive correlation between FSSG and HRQOL was observed. Based on the analysis, severity of esophagitis at baseline, complications of hypertension, higher HRQOL mental score at baseline, and higher FSSG score at baseline were predictors of responders. Gastrectomy, complication of insomnia, and prior medication with proton pump inhibitors were predictors of non-responders. Conclusion: Evaluating patients’ symptoms during the fourth week of rabeprazole therapy allows predictions of subsequent changes in subjective symptoms and HRQOL.

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“…PPIs are typically taken in the morning, but other regimens have been suggested, including evening or twice-daily administration, especially in patients with night-time heartburn. 22,23 Other variables were associated with a worsening of HRQL only on several of the QOLRAD subscales. Women, for example, were more likely to report a worsening of HRQL for the 'food ⁄ drink' and 'vitality' dimensions.…”

Section: Discussionmentioning

confidence: 99%