Therapeutic payload delivery to the myocardium: Evolving strategies and obstacles

Shazly, Tarek; Smith, Arianna; Uline, Mark J.; Spinale, Francis G.

doi:10.1016/j.xjon.2022.04.043

Cited by 4 publications

(1 citation statement)

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“…Meanwhile, there is a growing consensus in favor of minimally percutaneous invasive procedures due to their lower risk profile than open-chest procedures or intracoronary infusion of the hydrogel [14]. Thus, transcatheter endomyocardial alginate hydrogel injection (TEAi) is emerging as a promising solution; however, its practical application is challenged by the inherent high viscosity of alginate hydrogels, leading to catheter lumen occlusion, and the requirement for facile catheter manipulability [15].…”

Section: Introductionmentioning

confidence: 99%

Percutaneous Alginate Hydrogel Endomyocardial Injection with a Novel Dedicated Catheter Delivery System: An Animal Feasibility Study

Wang,

Gao,

Lim

et al. 2024

J. of Cardiovasc. Trans. Res.

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The objective of this preclinical study was to evaluate the feasibility and safety of transcatheter endocardial alginate hydrogel injection (TEAi) in a large animal model, utilizing the high-stiffness XDROP® alginate hydrogel in combination with the dedicated EndoWings® catheter-based system. All swine (n = 9) successfully underwent TEAi without complications. Acute results from a subset of animals (n = 5) demonstrated the ability of the catheter to access a wide range of endomyocardial areas and achieve consecutive circumferential hydrogel distribution patterns within the mid-left ventricular wall. Histological examinations at 6 months (n = 4) demonstrated that the XDROP® remained localized within the cardiac tissue. In addition, serial echocardiographic imaging showed that XDROP® had no adverse impacts on LV systolic and diastolic functions. In conclusion, this innovative combination technology has the potential to overcome the translational barriers related to alginate hydrogel delivery to the myocardium. Graphical abstract

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Section: Introductionmentioning

confidence: 99%