Therapeutic peptidomimetics in metabolic diseases

Sirhan, Worood; Piran, Ron

doi:10.1016/b978-0-12-820141-1.00023-6

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Strategies To Enhance the Efficacy Of Nafld Drug Candidates1

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2023

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“…Glucagon is a 29 amino acids long peptide hormone (HSQGTFTSDYSKYLDSRRAQDFVQWLMNT) secreted from the pancreatic α cells [ 97 , 98 ]. Its production is regulated by various factors (stimulated by hypoglycemia) or substances (inhibited by amylin and insulin) [ 99 ].…”

Section: Strategies To Enhance the Efficacy Of Nafld Drug Candidatesmentioning

confidence: 99%

Pharmaceutical Strategies to Improve Druggability of Potential Drug Candidates in Nonalcoholic Fatty Liver Disease Therapy

et al. 2023

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Nonalcoholic fatty liver disease (NAFLD) has become globally prevalent and is the leading cause of chronic liver disease. Although NAFLD is reversible without medical intervention in the early stage, the condition could be sequentially worsened to nonalcoholic steatohepatitis (NASH) and, eventually, cirrhosis and hepatic cancer. The progression of NAFLD is related to various factors such as genetics, pre-disposed metabolic disorders, and immunologic factors. Thankfully, to date, there have been accumulating research efforts and, as a result, different classes of potent drug candidates have been discovered. In addition, there have also been various attempts to explore pharmaceutical strategies to improve the druggability of drug candidates. In this review, we provided a brief overview of the drug candidates that have undergone clinical trials. In the latter part, strategies for developing better drugs are discussed.

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Section: Strategies To Enhance the Efficacy Of Nafld Drug Candidatesmentioning

confidence: 99%