Therapeutic Perspectives in Actinic and Other Keratoses

Die aktinische Keratose

“…Ebenfalls ein Standardtherapieverfahren ist die Kürettage bzw.die Elektrodesikkation [28]. Wie auch die chirurgische (Shave-)Exzision ist die Kürettage besonders bei unklaren klinischen Befungiogeneseinduktion und Immunsuppression postuliert werden.…”

Solar cheilosis: An ominous precursor

“…90 More vigorous application is required for SC than for AK. 71 Chemical peeling is another therapeutic modality that has been used to treat SC. However, these methods tend to have very low clinical and histologic success rates and are therefore not often utilized.…”

“…64,70 Patients should be forewarned that this unsightly reaction tends to occur 5 to 15 days after the start of the treatment. 71 A standard treatment for SC is a 5% solution of 5-FU applied two to three times a day for 9 to 15 days. It may not resolve SC histologically, despite clinical remission.…”

Management of actic keratoses

“…Cryosurgery. This is the most frequently employed method for managing AKs with cure rates in excess of 98% being reported 8,20,[22][23][24][25][26] (Figure 3). Although some clinicians are adept at treating diffuse and confluent lesions, 24 cryosurgery is most suitable for managing isolated and widely scattered lesions.…”

“…Although effective, 8,20,22,25 electrodessication and curettage (ED&C) is less efficient than cryosurgery; requires the use of a local anesthetic; is more likely to result in a scar or hypopigmentation; and produces a wound which requires longer to heal. In this author's opinion, ED&C should be employed when: (1) the lesion is resistant to cryosurgery, or (2) the lesion has just begun to evolve into a superficially invasive SCC.…”