Therapeutic perspectives of the black cumin component thymoquinone: A review

Sarkar, Chandan Kumar; Jamaddar, Sarmin; Islam, Tawhida; Mondal, Milon; Islam, Muhammad Torequl; Mubarak, Mohammad S.

doi:10.1039/d1fo00401h

Cited by 24 publications

(20 citation statements)

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“…Owing to promising therapeutic effects and reduced side effects, the use of medicinal plants as therapeutic agents is currently enjoying much attention in comparison to modern allopathic medicines [ 1 ]. Nigella sativa L., of the Ranunculaceae family, is an herb with rich historical background [ 2 ]. The seeds and oil of Nigella sativa L. are used as antihypertensives, liver tonics, diuretics, and antidiarrheal, analgesic, antibacterial, and antifungal agents (3).…”

Section: Introductionmentioning

confidence: 99%

“…The seeds and oil of Nigella sativa L. are used as antihypertensives, liver tonics, diuretics, and antidiarrheal, analgesic, antibacterial, and antifungal agents (3). Thymoquinone (TQ) is the major bioactive component of the oil and is regarded as the main therapeutic constituent of NSO [ 2 , 3 ]. In addition to TQ (30–48%), thymohydroquinone, dithymoquinone, cymene (7–15%), carvacrol (6–12%), 4-terpineol (2–7%), t -anethol (1–4%), α-pinene, and thymol are present at good concentrations in NSO.…”

Section: Introductionmentioning

confidence: 99%

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Development and Optimization of Methylcellulose-Based Nanoemulgel Loaded with Nigella sativa Oil for Oral Health Management: Quadratic Model Approach

et al. 2022

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The present study aimed to develop a local dental nanoemulgel formulation of Nigella sativa oil (NSO) for the treatment of periodontal diseases. NSO purchased from a local market was characterized using a GC–MS technique. A nanoemulsion containing NSO was prepared and incorporated into a methylcellulose gel base to develop the nanoemulgel formulation. The developed formulation was optimized using a Box–Behnken statistical design (quadratic model) with 17 runs. The effects of independent factors, such as water, oil, and polymer concentrations, were studied on two dependent responses, pH and viscosity. The optimized formulation was further evaluated for droplet size, drug release, stability, and antimicrobial efficacy. The developed formulation had a pH of 7.37, viscosity of 2343 cp, and droplet size of 342 ± 36.6 nm. Sustained release of the drug from the gel for up to 8 h was observed, which followed Higuchi release kinetics with non-Fickian diffusion. The developed nanoemulgel formulation showed improved antimicrobial activity compared to the plain NSO. Given the increasing emergence of periodontal diseases and antimicrobial resistance, an effective formulation based on a natural antibacterial agent is warranted as a dental therapeutic agent.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development and Optimization of Methylcellulose-Based Nanoemulgel Loaded with Nigella sativa Oil for Oral Health Management: Quadratic Model Approach

et al. 2022

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“…There will be 26 million new instances of cancer and 17 million annual cancer deaths by the year 2030, according to estimates [ 57 ]. Therefore, there is a continuing need to provide novel, efficient, and cost-effective anticancer medications [ 58 ]. Medicinal plants and their chemical constituents have been utilized to treat human ailments since the beginning of ancient medicine.…”

Section: Resultsmentioning

confidence: 99%

Ethnomedicinal Uses, Phytochemistry, and Therapeutic Potentials of Litsea glutinosa (Lour.) C. B. Robinson: A Literature-Based Review

et al. 2022

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Litsea glutinosa (Lour.) C. B. Robinson, belonging to the family Lauraceae, is a multipurpose and fast-growing evergreen or deciduous tree that has been traditionally used for numerous purposes such as treatment for diarrhea, dysentery, abdominal pain, indigestion, gastroenteritis, edema, traumatic injuries, colds, arthritis, asthma, diabetes, pain relief, and poignant sexual power. This study aimed to summarize the chemical reports, folk values, and phytopharmacological activities of L. glutinosa, based on available information screened from diverse databases. An up-to-date electronic-based search was accomplished to obtain detailed information, with the help of several databases such as Google Scholar, Scopus, SpringerLink, Web of Science, ScienceDirect, ResearchGate, PubMed, ChemSpider, Elsevier, BioMed Central, and the USPTO, CIPO, INPI, Google Patents, and Espacenet, using relevant keywords. Outcomes advocate that, up to the present time, alkaloids, glycosides, and terpenoids are abundant in, and the most bioactive constituents of, this natural plant. Results demonstrated that L. glutinosa has various remarkable biological activities, including antioxidant, anti-inflammatory, anti-microbial, anticancer, antipyretic, anti-diabetic, analgesic, hepatoprotective, and wound-healing activity. One study revealed that L. glutinosa exhibited significant aphrodisiac and anti-infertility activity. Nevertheless, no clinical studies have been cited. Taken together, L. glutinosa may be one of the significant sources of bioactive constituents that could potentially lead to different effective pharmacological activities. On the other hand, future research should focus on clinical studies and several toxicity evaluations, such as sub-chronic toxicity, teratogenicity, and genotoxicity.

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“…TQ reportedly possesses numerous pharmacological properties, such as antioxidative, neuroprotective, and anti-carcinogenic activities. Thus, it exerts vital functions as a chemopreventive and therapeutic agent in the treatment of various diseases and conditions ( Sarkar et al, 2021 ). Üstünet al conducted a study (pre-treated mice with or without varying doses of TQ prior) at the animal level.…”

Section: Plant-derived Medicines Limiting Platinum-induced Peripheral Neurotoxicitymentioning

confidence: 99%

Application Potential of Plant-Derived Medicines in Prevention and Treatment of Platinum-Induced Peripheral Neurotoxicity

Jia

et al. 2022

Front. Pharmacol.

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As observed with other chemotherapeutic agents, the clinical application of platinum agents is a double-edged sword. Platinum-induced peripheral neuropathy (PIPN) is a common adverse event that negatively affects clinical outcomes and patients’ quality of life. Considering the unavailability of effective established agents for preventing or treating PIPN and the increasing population of cancer survivors, the identification and development of novel, effective interventions are the need of the hour. Plant-derived medicines, recognized as ideal agents, can not only help improve PIPN without affecting chemotherapy efficacy, but may also produce synergy. In this review, we present a brief summary of the mechanisms of platinum agents and PIPN and then focus on exploring the preventive or curative effects and underlying mechanisms of plant-derived medicines, which have been evaluated under platinum-induced neurotoxicity conditions. We identified 11 plant extracts as well as 17 plant secondary metabolites, and four polyherbal preparations. Their effects against PIPN are focused on oxidative stress and mitochondrial dysfunction, glial activation and inflammation response, and ion channel dysfunction. Also, ten clinical trials have assessed the effect of herbal products in patients with PIPN. The understanding of the molecular mechanism is still limited, the quality of clinical trials need to be further improved, and in terms of their efficacy, safety, and cost effectiveness studies have not provided sufficient evidence to establish a standard practice. But plant-derived medicines have been found to be invaluable sources for the development of natural agents with beneficial effects in the prevention and treatment of PIPN.

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Therapeutic perspectives of the black cumin component thymoquinone: A review

Abstract: The dietary phytochemical thymoquinone, obtained from the black and angular seeds of Nigella sativa, is a promising monoterpenoid hydrocarbons, which has been receiving massive attention for its therapeutic potential and pharmacological properties.

Cited by 24 publications

References 254 publications

Development and Optimization of Methylcellulose-Based Nanoemulgel Loaded with Nigella sativa Oil for Oral Health Management: Quadratic Model Approach

Development and Optimization of Methylcellulose-Based Nanoemulgel Loaded with Nigella sativa Oil for Oral Health Management: Quadratic Model Approach

Ethnomedicinal Uses, Phytochemistry, and Therapeutic Potentials of Litsea glutinosa (Lour.) C. B. Robinson: A Literature-Based Review

Application Potential of Plant-Derived Medicines in Prevention and Treatment of Platinum-Induced Peripheral Neurotoxicity

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