Therapeutic perspectives on the combination of α-lipoic acid and vitamin E

González-Pérez, Óscar; González-Castañeda, Rocío E.

doi:10.1016/j.nutres.2005.11.011

Cited by 43 publications

(13 citation statements)

References 48 publications

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“…Alpha‐lipoic acid has the ability to be absorbed in the intestine and also can cross the blood–brain barrier. Therefore, its supplementation can impart hypotriglyceridemic and hypoglycemic properties in chicken birds along with other therapeutic benefits including stress management (Gonzalez‐Perez & Gonzalez‐Castaneda, ). However, the in vivo ALA and DHLA concentration remain indecisive until now.…”

Section: Action Mechanism Of α‐Lipoic Acidmentioning

confidence: 99%

Alpha‐lipoic acid: An inimitable feed supplement for poultry nutrition

Sohaib

Anjum

Nasir

et al. 2017

Animal Physiology Nutrition

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Alpha-lipoic acid (ALA) is a multifunction antioxidant that is produced in small amount by cells as well as its dietary provision facilitates fatty acid mobilization, energy expenditure as well as can scavenge free radicals in poultry birds. It exists in oxidized as well as reduced form, characterized by growth promoting, anti-inflammatory, antioxidative, immunostimulatory, and hypocholesterolemic properties when fed as dietary supplement to farm animals particularly chicken birds. Recently, several studies reported that dietary supplementation of ALA can influence growth performance indicators, immunological, biochemical characteristics, lipid metabolism, and oxidative stress as well as increase antioxidant potential and storability of poultry meat and meat products. Accordingly, this paper adds the reviews and discusses the outcomes of studies documenting the effect of lipoic acid dietary fortification on growth performance, biochemical, and immunological characteristics as well as the effects on lipid peroxidation of fresh meat and meat-based products. Furthermore, this paper also describes the possibilities of utilization of ALA as a feed additive in poultry nutrition to improve the growth performance of poultry as well as meat quality of resultant chicken birds.

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Section: Action Mechanism Of α‐Lipoic Acidmentioning

confidence: 99%

Alpha‐lipoic acid: An inimitable feed supplement for poultry nutrition

Sohaib

Anjum

Nasir

et al. 2017

Animal Physiology Nutrition

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show abstract

“…The α-LA can be synthesized de novo in most animals, plants and microorganisms and it is a cofactor of different complexes in the oxidative decarboxylation enzyme of the Krebs cycle, i.e., pyruvate dehydrogenase and α-ketoglutarate dehydrogenase (Bast and Haenen, 2003;Trattner et al, 2007). Previous studies have shown that α-LA and its reduced form as dihydrolipoic acid (DHLA) have potent antioxidant capacity in both aqueous and lipidic environments because of the amphiphilic property to cross the cell membrane and the blood brain barrier (Gonzalez-Perez and Gonzalez-Castaneda, 2006;Yoshikawa et al, 1996). Appropriate supplementation of α-LA in the diet can significantly improve growth performance, survival and antioxidant status in abalone Haliotis discus hannai (Zhang et al, 2010) and hybrid tilapia Oreochromis niloticus × Oreochromis aureus (Xiong et al, 2012) due to its ability to reduce reactive oxygen species (ROS) (Bast and Haenen, 2003) and regenerate other antioxidants such as vitamin C, vitamin E, glutathione, coenzyme Q10 and ubiquinone (Han et al, 1997;Park et al, 2006;Trattner et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Effects of α-lipoic acid on growth performance, body composition, antioxidant status and lipid catabolism of juvenile Chinese mitten crab Eriocheir sinensis fed different lipid percentage

Liu

et al. 2018

Aquaculture

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“…Ascorbic acid (AA) (11) and α-lipoic acid (ALA) (5) are primary antioxidants in biological systems and are capable of breaking the chain of lipid peroxidation in cell membranes.…”

Section: Introductionmentioning

confidence: 99%

Effects of ascorbic and α-lipoic acid on secretion of HSP- 70 and apoptosis in liver and kidneys of broilers exposed to heat stress

Kapakin¹,

Kübra²,

Recep³

et al. 2012

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Summary:The objective of this experiment was to evaluate the ameliorative effect of L-ascorbic acid (AA) and α-lipoic acid (ALA) on tissue damage caused by heat stress (HS) in the liver and kidneys of broilers, and to correlate this effect with the secretion of the heat shock protein-70 (HSP-70) protein and apoptosis. The study broilers of breed Ross 308 were used. Animals included in the control were divided into four groups. Group TN; control thermoneutral broilers (24 0 C) were not administered with antioxidants in the diet and not subjected to heat stress (TN). Group HS; broilers not administered with antioxidants in the diet but subjected to heat stress (34 0 C) (HS). Group HS+AA; broilers subjected to heat stress (34 0 C) and administered with ascorbic acide (AA).HS+ALA; broilers subjected to heat stress (34 0 C) and administered with α-lipoic acid (AAA). Then, all of the groups were sacrificed and organs (liver and kidney) were collected for histopathological and immunohistochemstry evaluations. Histopathological examination demonstrated that, in the liver and kidneys in Group HS, the blood vessels were very hyperemic. Hepatocytes as well as in tubulo epithelial cells of kidney displayed degenerative alterations. Lesions similar to those observed in Group HS were also observed in Groups HS+AA and HS+ALA. However, the liver and kidney HSP-70 secration were greater in Groups HS+AA, HS+ALA and TN than in Groups HS. The greatest number of apoptotic cells was determined in Group HS, whilst the lowest numbers were determined in Groups TN and HS+ALA. Dietary supplementation with ALA was more effective than AA at preventing tissue damage. Key words: Ascorbic acid, α-lipoic acid, apoptosis, broiler, heat shock proteins, heat stress. Anahtar sözcükler: Askorbik asit, α-lipoik asit, apoptozis, broiler, ısı şok proteini, sıcaklık stresi. Sıcaklık

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Therapeutic perspectives on the combination of α-lipoic acid and vitamin E

Cited by 43 publications

References 48 publications

Alpha‐lipoic acid: An inimitable feed supplement for poultry nutrition

Alpha‐lipoic acid: An inimitable feed supplement for poultry nutrition

Effects of α-lipoic acid on growth performance, body composition, antioxidant status and lipid catabolism of juvenile Chinese mitten crab Eriocheir sinensis fed different lipid percentage

Effects of ascorbic and α-lipoic acid on secretion of HSP- 70 and apoptosis in liver and kidneys of broilers exposed to heat stress

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