Therapeutic potential and limitations of curcumin as antimetastatic agent

Dytrych, Pavel; Kejík, Zdeněk; Hajduch, Jan; Kaplánek, Robert; Veselá, Kateřina; Kučnirová, Kateřina; Skaličková, Markéta; Venhauerová, Anna; Hoskovec, David; Martásek, Pavel; Jakubek, Milan

doi:10.1016/j.biopha.2023.114758

Cited by 17 publications

(6 citation statements)

References 342 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This molecule shows high tolerability and safety in physiological environments (i.e., human models) [ 28 , 29 , 30 , 31 ], as well as significant biological potential for therapeutic application. Among its potentialities, curcumin acts both in chemoprevention and directly in cancer cells [ 9 , 32 ]. In vitro and in vivo studies have shown the anticancer activity of curcumin against (i) breast, (ii) lung, (iii) prostate, (iv) pancreas, and (v) colorectal cancer, among other types [ 7 , 33 , 34 , 35 ].…”

Section: Curcumin and Its Anticancer Effectsmentioning

confidence: 99%

See 1 more Smart Citation

Recent Trends in Curcumin-Containing Inorganic-Based Nanoparticles Intended for In Vivo Cancer Therapy

Dourado,

Miranda,

de Oliveira

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

Curcumin is a natural compound that has been widely investigated thanks to its various biological properties, including antiproliferative. This molecule acts on different cancers such as lung, breast, pancreatic, colorectal, etc. However, the bioactive actions of curcumin have limitations when its physicochemical properties compromise its pharmacological potential. As a therapeutic strategy against cancer, curcumin has been associated with inorganic nanoparticles. These nanocarriers are capable of delivering curcumin and offering physicochemical properties that synergistically enhance anticancer properties. This review highlights the different types of curcumin-based inorganic nanoparticles and discusses their physicochemical properties and in vivo anticancer activity in different models of cancer.

show abstract

Section: Curcumin and Its Anticancer Effectsmentioning

confidence: 99%

“…Curcumin is a major natural compound obtained from the rhizome of Curcuma longa L. [ 8 ]. Despite its high biological potential, it has biopharmaceutical limitations that compromise its clinical use in cancer therapy [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Trends in Curcumin-Containing Inorganic-Based Nanoparticles Intended for In Vivo Cancer Therapy

Dourado,

Miranda,

de Oliveira

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Antibacterial, antioxidant, and anti-inflammatory for wound healing [271] Nanoparticles Different types of cancer [272] Chitosan sponge-cryogel Wound healing [273] Nanofibrous meshes Wound healing [274] Cannabis sativa…”

Section: Curcuma Longa Curcuminmentioning

confidence: 99%

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

Isopencu,

Covaliu-Mierlă,

Deleanu

2023

Plants

View full text Add to dashboard Cite

Transdermal delivery devices and wound dressing materials are constantly improved and upgraded with the aim of enhancing their beneficial effects, biocompatibility, biodegradability, and cost effectiveness. Therefore, researchers in the field have shown an increasing interest in using natural compounds as constituents for such systems. Plants, as an important source of so-called “natural products” with an enormous variety and structural diversity that still exceeds the capacity of present-day sciences to define or even discover them, have been part of medicine since ancient times. However, their benefits are just at the beginning of being fully exploited in modern dermal and transdermal delivery systems. Thus, plant-based primary compounds, with or without biological activity, contained in gums and mucilages, traditionally used as gelling and texturing agents in the food industry, are now being explored as valuable and cost-effective natural components in the biomedical field. Their biodegradability, biocompatibility, and non-toxicity compensate for local availability and compositional variations. Also, secondary metabolites, classified based on their chemical structure, are being intensively investigated for their wide pharmacological and toxicological effects. Their impact on medicine is highlighted in detail through the most recent reported studies. Innovative isolation and purification techniques, new drug delivery devices and systems, and advanced evaluation procedures are presented.

show abstract

“…In particular, positive effects have been observed on inflammation, skin, eye, central nervous system, respiratory, cardiovascular, gastrointestinal, urogenital, and metabolic disorders . Curcumin has also shown therapeutic potential in chemoprevention and for the treatment of cancer. − Although curcuminoids have been successfully evaluated for a wide range of biological activities, they show two main limitations related to the poor bioavailability and rapid metabolism . The metabolism of curcumin in humans produces several products using three main pathways, degradation, O-conjugation, and reduction. , The reduction products are mainly tetrahydrocurcumin (THcurcH) (Scheme ), hexahydrocurcumin, and octahydrocurcumin. − THcurcH has been reported to show a wide range of therapeutic features analogous to curcumin such as radical-scavenging, antioxidant, anticarcinogenic, and antimetastatic activities, but unlike curcumin, THcurcH has greater bioavailability. , Having additional hydrogens, THcurcH is more hydrophilic than curcumin and pharmacokinetic assessments reveal that it is more stable than curcumin in phosphate buffers at neutral pH and plasma .…”

Section: Introductionmentioning

confidence: 99%

Ru(II)-Arene Complexes of Curcumin and Bisdesmethoxycurcumin Metabolites

Pagliaricci,

Pettinari,

Marchetti

et al. 2024

Inorg. Chem.

View full text Add to dashboard Cite

Curcuminoids and their complexes continue to attract attention in medicinal chemistry, but little attention has been given to their metabolic derivatives. Here, the first examples of (arene)Ru(II) complexes with curcuminoid metabolites, tetrahydrocurcumin (THcurcH), and tetrahydrobisdesmethoxycurcumin (THbdcurcH) were prepared and characterized. The neutral complexes [Ru(arene)(THcurc)Cl] and [Ru(arene)(THbdcurc)Cl] (arene = cymene, benzene, or hexamethylbenzene) were characterized by NMR spectroscopy and ESI mass spectrometry, and the crystal structures of the three complexes were determined by X-ray diffraction analysis. Compared to curcuminoids, these metabolites lose their conjugated double bond system responsible for their planarity, showing unique closed conformation structures. Both closed and open conformations have been analyzed and rationalized by using density functional theory (DFT). The cytotoxicity of the complexes was evaluated in vitro against human ovarian carcinoma cells (A2780 and A2780cisR), human breast adenocarcinoma cells (MCF-7 and MCF-7CR), as well as against non-tumorigenic human embryonic kidney cells (HEK293) and human breast (MCF-10A) cells and compared to the free ligands, cisplatin, and RAPTA-C. There is a correlation between cellular uptake and the cytotoxicity of the compounds, suggesting that cellular uptake and binding to nuclear DNA may be the major pathway for cytotoxicity. However, the levels of complex binding to DNA do not strictly correlate with the cytotoxic potency, indicating that other mechanisms are also involved. In addition, treatment of MCF-7 cells with [Ru(cym)(THcurc)Cl] showed a significant decrease in p62 protein levels, which is generally assumed as a noncisplatin-like mechanism of action involving autophagy. Hence, a cisplatin-and a noncisplatin-like concerted mechanism of action, involving both apoptosis and autophagy, is possible.

show abstract

Therapeutic potential and limitations of curcumin as antimetastatic agent

Cited by 17 publications

References 342 publications

Recent Trends in Curcumin-Containing Inorganic-Based Nanoparticles Intended for In Vivo Cancer Therapy

Recent Trends in Curcumin-Containing Inorganic-Based Nanoparticles Intended for In Vivo Cancer Therapy

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

Ru(II)-Arene Complexes of Curcumin and Bisdesmethoxycurcumin Metabolites

Contact Info

Product

Resources

About