Therapeutic potential and nutritional significance of Ganoderma lucidum – a comprehensive review from 2010 to 2022

Abstract

The medicinal reputation of Ganoderma lucidum and its unique pharmaceutical and nutritional properties have led to its demand as an important resource for nutrient supplements in the food industry.

Lipid metabolism disorder in diabetic kidney disease

“…FYGL is a water-soluble substance extracted from Ganoderma lucidum , highly branched proteoglycan that protects tissues from oxidative stress damage ( 208 ). FYGL significantly inhibited HG/PA-induced proliferation of HBZY-1 cells, ROS generation, and malondialdehyde (MDA) production; promoted Superoxide Dismutase(SOD) activity; and suppressed the expression of NADPH oxidase 1(NOX1), NADPH oxidase 4(NOX4), mitogen-activated protein kinase, NF-κB, and pro-fibronectin expression.…”

Perspectivas do potencial imunomodulador e antineoplásico de polissacarídeos e outras biomoléculas de Ganoderma spp.

“…Estudos têm sido realizados para investigar seus potenciais efeitos antitumorais, embora o mecanismo de ação ainda não esteja completamente elucidado. Adicionalmente, pesquisas recentes sugerem que os macrofungos do gênero Ganoderma podem representar uma abordagem promissora para o desenvolvimento de medicamentos anticancerígenos devido à sua atividade antineoplásica e imunomoduladora (Ahmad et al, 2021;Cao et al, 2018;Rupeshkumar et al, 2016;Smith et al, 2002;Swallah et al, 2023;Zhu et al, 2017).…”

Novel A-seco-nortriterpenoids from Ganoderma cochlear inhibiting Tau pathology by activating AMPK-ULK1-mediated autophagy

“…Ganoderma has attracted significant attention from pharmacologists, chemists, and phytochemists because it has long been used as a traditional medicine in many countries 1,2 and is also an important source of meroterpenoids and lanostane triterpenoids with significant bioactivities and captivating structures. [3][4][5][6][7][8][9] In particular, Ganoderma triterpenoids (GTs) have been widely studied as the main active constituents of Ganoderma for their anti-tumor, anti-aging, liver-protective, and neuroprotective activities.…”