Therapeutic Potential of Aloe vera and Aloe vera–Conjugated Silver Nanoparticles on Mice Exposed to Hexavalent Chromium

Nauroze, Tooba; Ali, Shaukat; Andleeb, Shagufta; Ara, Chaman; Liaqat, Iqra; Mushtaq, Hina; Mumtaz, Samaira; Kanwal, Lubna; Abbas, Afshan Syed; Mumtaz, Shumaila; Farooq, Muhammad Adeel; Khan, Istaqlal Hussain

doi:10.1007/s12011-024-04105-8

Biol Trace Elem Res

2024

DOI: 10.1007/s12011-024-04105-8

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Therapeutic Potential of Aloe vera and Aloe vera–Conjugated Silver Nanoparticles on Mice Exposed to Hexavalent Chromium

Tooba Nauroze,

Shaukat Ali,

Shagufta Andleeb

et al.

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2024

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Chitosan membranes incorporating Aloe vera glycolic extract with joint synthesis of silver nanoparticles for the treatment of skin lesions

Amaral,

Santana,

Lisboa

et al. 2024

Drug Deliv. and Transl. Res.

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New wound dressings based on polymeric membranes have been widely exploited for clinical applications to assist in the healing process and prevent additional complications (e.g., bacterial infections). Here we propose the development of a new production method of polymeric membranes based on chitosan, incorporating glycolic extract of Aloe vera with joint synthesis of silver nanoparticles for use as a new bioactive dressing. The membranes were obtained by casting technique, and their morphological, physicochemical characteristics, degree of swelling, degradation profile and antimicrobial activity evaluated. Morphological analyzes confirmed the synthesis and presence of silver nanoparticles in the polymeric membrane. The chemical compatibility between the materials was demonstrated through thermal analysis (TGA and DSC) combined with ATR-FTIR tests, showing the complexation of the membranes (Mb-Ch-Ex.Av-NPs). All membranes were characterized as hydrophilic material (with a contact angle (ө) < 90°); however, the highest degree of swelling was obtained for the chitosan. (Mb-Ch) membrane (69.91 ± 5.75%) and the lowest for Mb-Ch-Ex.Av-NPs (26.62 ± 8.93%). On the other hand, the degradation profile was higher for Mb-Ch-Ex.Av-NPs (77.85 ± 7.51%) and lower for Mb-Ch (57.60 ± 2.29%). The manufactured bioactive dressings showed activity against Escherichia coli and Staphylococcus aureus. Our work confirmed the development of translucent and flexible chitosan-based membranes, incorporating Aloe vera glycolic extract with joint synthesis of silver nanoparticles for use as a new bioactive dressing, with proven antimicrobial activity. Graphical Abstract

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Chitosan membranes incorporating Aloe vera glycolic extract with joint synthesis of silver nanoparticles for the treatment of skin lesions

Amaral,

Santana,

Lisboa

et al. 2024

Drug Deliv. and Transl. Res.

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show abstract

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Therapeutic Potential of Aloe vera and Aloe vera–Conjugated Silver Nanoparticles on Mice Exposed to Hexavalent Chromium

Cited by 1 publication

References 62 publications

Chitosan membranes incorporating Aloe vera glycolic extract with joint synthesis of silver nanoparticles for the treatment of skin lesions

Chitosan membranes incorporating Aloe vera glycolic extract with joint synthesis of silver nanoparticles for the treatment of skin lesions

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