Therapeutic Potential of Antimicrobial Peptides for Wound Healing

Nasseri, Sepideh; Sharifi, Mohammadreza

doi:10.1007/s10989-021-10350-5

Cited by 20 publications

(7 citation statements)

References 94 publications

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“…[76][77][78][79][80] Nevertheless, presence of antibiotic resistant bacteria in the wound site results in delay of the wound healing and must be well considered while the development of wound healing methodologies. 81 AMPs present favorable wound repairing properties with playing a role in all steps of wound healing and possessing an antimicrobial activity. 82 For instance, Takahashi et al demonstrated that Human β-Defensin-3 AMP accelerates the wound healing by triggering the migration and proliferation of human fibroblast with expression of angiogenic growth factors.…”

Section: Discussionmentioning

confidence: 99%

Effect of antimicrobial peptide conjugated surgical sutures on multiple drug-resistant microorganisms

et al. 2022

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Surgical site infections are commonly encountered as a risk factor in clinics that increase the morbidity of a patient after a surgical operation. Surgical sutures are one of the leading factor for the formation of surgical site infections that induce bacterial colonization by their broad surface area. Current strategies to overcome with surgical site infections consist utilization of antibiotic agent coatings such as triclosan. However, the significant increase in antibiotic resistance majorly decreases their efficiency against recalcitrant pathogens such as; Pseudomonas aeruginosa and Staphylococcus aureus. Therefore, the development of a multi drug-resistant antimicrobial suture without any cytotoxic effect to combat surgical site infections is vital. Antimicrobial peptides are the first defense line which has a broad range of spectrum against Gram-positive, and Gram-negative bacteria and even viruses. In addition, antimicrobial peptides have a rapid killing mechanism which is enhanced by membrane disruption and inhibition of functional proteins in pathogens without the development of antimicrobial resistance. In the scope of the current study, the antimicrobial effect of antimicrobial peptide conjugated poly (glycolic acid-co-caprolactone) (PGCL) sutures were investigated against P. aeruginosa and methicillin-resistant S. aureus (MRSA) strains by using antimicrobial peptide sequences of KRFRIRVRV-NH2, RWRWRWRW-NH2 and their dual combination (1:1). In addition, in vitro wound scratch assays were performed to evaluate the effect of antimicrobial peptide conjugated sutures on keratinocyte cell lines. Our results indicated that antimicrobial peptide modified sutures could be a potential novel medical device to overcome surgical site infections by the superior acceleration of wound healing.

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Section: Discussionmentioning

confidence: 99%

Effect of antimicrobial peptide conjugated surgical sutures on multiple drug-resistant microorganisms

et al. 2022

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“…They also discussed innovative delivery systems, such as nanoparticles and electrospun fibrous scaffolds, highlighting their potential as possibly more effective therapeutics than antibiotics, especially in the context of diabetic wound closure. 66 Aimed at increased angiogenesis in the proliferative phase, there is evidence that N-acetylcysteine can increase amputation stump perfusion with the goal of better long-term wound healing and more efficient scar formation. 67 Stem cell therapy, particularly employing cells from the human amniotic membrane, represents an auspicious avenue for antifibrotic treatment.…”

Section: Recent Developments In Wound Healingmentioning

confidence: 99%

Wound Healing: Cellular Review With Specific Attention to Postamputation Care

Kirwin

2024

Cutis

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Wound healing in adults is a complex dynamic process that usually takes the greater part of 1 year to completely resolve and is marked by the end of scar formation.• Postamputation residual limbs are subject to mechanical and biophysical stress to which the overlying skin is not accustomed. Skin treatment aims at mitigating these stresses.• The major dermatologic barriers to successful wound healing following amputation include infection, skin breakdown, formation of chronic wounds and granulation tissue, heterotopic ossification, and hyperhidrosis.

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“…This property makes AMPs particularly interesting in light of antibiotic resistance by multiple bacterial strains, one of the most serious global health problems that humans currently face [3,4]. In addition to providing promising templates for the design of new antibiotics, AMPs have proven useful in other medical fields, such as cancer control [5], treatment of sexually transmitted diseases [6], and wound Toxins 2024, 16, 150 2 of 26 healing [7]. The general antimicrobial mechanism of AMPs involves their interaction with cell membranes, either increasing their permeability or triggering lysis and release of intracellular contents [8].…”

Section: Introductionmentioning

confidence: 99%

Diversity and Molecular Evolution of Antimicrobial Peptides in Caecilian Amphibians

Benítez-Prián,

Lorente-Martínez,

Agorreta

et al. 2024

Toxins

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Antimicrobial peptides (AMPs) are key molecules in the innate immune defence of vertebrates with rapid action, broad antimicrobial spectrum, and ability to evade pathogen resistance mechanisms. To date, amphibians are the major group of vertebrates from which most AMPs have been characterised, but most studies have focused on the bioactive skin secretions of anurans (frogs and toads). In this study, we have analysed the complete genomes and/or transcriptomes of eight species of caecilian amphibians (order Gymnophiona) and characterised the diversity, molecular evolution, and antimicrobial potential of the AMP repertoire of this order of amphibians. We have identified 477 candidate AMPs within the studied caecilian genome and transcriptome datasets. These candidates are grouped into 29 AMP families, with four corresponding to peptides primarily exhibiting antimicrobial activity and 25 potentially serving as AMPs in a secondary function, either in their entirety or after cleavage. In silico prediction methods were used to identify 62 of those AMPs as peptides with promising antimicrobial activity potential. Signatures of directional selection were detected for five candidate AMPs, which may indicate adaptation to the different selective pressures imposed by evolutionary arms races with specific pathogens. These findings provide encouraging support for the expectation that caecilians, being one of the least-studied groups of vertebrates, and with ~300 million years of separate evolution, are an underexplored resource of great pharmaceutical potential that could help to contest antibiotic resistance and contribute to biomedical advance.

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Therapeutic Potential of Antimicrobial Peptides for Wound Healing

Cited by 20 publications

References 94 publications

Effect of antimicrobial peptide conjugated surgical sutures on multiple drug-resistant microorganisms

Effect of antimicrobial peptide conjugated surgical sutures on multiple drug-resistant microorganisms

Wound Healing: Cellular Review With Specific Attention to Postamputation Care

Diversity and Molecular Evolution of Antimicrobial Peptides in Caecilian Amphibians

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