Therapeutic potential of Benincasa cerifera: A review

Arora, Pranjul; Kaushik, Dhirender

doi:10.1007/s11655-016-2589-8

Cited by 6 publications

(4 citation statements)

References 38 publications

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“…B. hispida is widely used as a vegetable and for making candy. It is especially valued as a brain tonic in the treatment of mental disorders and as an effective antidote for alcohol and mercury poisoning [ 31 ]. Sarangdhara Samhitaa (an Ayurveda medicine book) describes its use in treating hemorrhage (especially in ulceration of lungs) and pulmonary complications.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Applications of Biostable Silver Nanoparticles Synthesized Using Peel Extract of Benincasa hispida: Antibacterial and Anticancer Activities

et al. 2020

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The purpose of this study was to fabricate biostable inorganic silver nanoparticles (AgNPs) using fresh peel (aqueous) extract of Benincasa hispida. A fast, robust, and eco-friendly approach was used for the synthesis of AgNPs, where bioactive components of peel extract of B. hispida acted as reducing and stabilizing agents. Synthesized AgNPs were characterized using a UV–Vis spectrophotometer, Fourier-transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), and electron microscopy. The synthesized nanoparticles exhibited maximum absorption at 418 nm under the typical AgNPs surface plasmon resonance band range. They depicted a mean size of 26 ± 2 nm with a spherical shape. Their therapeutic prospective was determined by evaluating their antimicrobial and anticancer potential. The bio-synthesized silver nanoparticles exhibited strong antimicrobial activity with minimum inhibitory concentration (MIC 50) values of 14.5, 8.6, 6.063, and 13.4 μg/mL against Staphylococcus aureus (ATCC 25923), Micrococcus luteus (ATCC 14593), Escherichia coli (ATCC 25922), and Klebsiella pneumonia (ATCC 13883), respectively. The biosynthesized AgNPs showed potent in vitro cytotoxicity against human cervical cancer cell line with a half maximal inhibitory concentration (IC50) value of 0.066 μg/mL; however, no cytotoxic effect was observed on normal human primary osteoblasts cell line. This study explored B. hispida extract and confirmed its effectiveness as a promising source in producing AgNPs that could be employed for several therapeutic applications.

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Section: Introductionmentioning

confidence: 99%

Therapeutic Applications of Biostable Silver Nanoparticles Synthesized Using Peel Extract of Benincasa hispida: Antibacterial and Anticancer Activities

et al. 2020

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“…The positive control was vincristine sulfate, which had an LC 50 of 0.367 g/ml. These fractions' results all point to the presence of powerful bioactive chemicals that could provide these two plants with anticancer or pesticidal properties (Arora & Kaushik, 2016). Likewise, methanolic extract of bottle gourd seeds shows anti‐cancerous activities.…”

Section: Health Beneficial Potentialmentioning

confidence: 99%

Vegetable seeds: A new perspective in future food development

Roy

Sarkar

Chakraborty

2022

Food Processing Preservation

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Traditionally, vegetables are consumed as ingredients of daily household meals. Before cooking, vegetables are washed thoroughly, unpeeled, and deseeded, followed by chopping into desired shapes and sizes. Vegetable peels and seeds are also byproducts of various food industries. If they are not used, they will contribute significantly to global garbage. On the contrary, developing novel functional foods and food ingredients out of unorthodox sources has become a trending issue among researchers. The focus of this review was to access the utility of seed flour from 16 commonly eaten seed‐bearing vegetables such as ash gourd (Benincasa hispida), bitter gourd (Momordica charantia), bottle gourd (Lagenaria siceraria), buffalo gourd (Cucurbita foetidissima), capsicum (Capsicum annuum), drumstick (Moringa oleifera), Gnetum (Gnetum gnemon), hemp (Cannabis sativa), lady's finger (Abelmoschus esculentus), noni (Morinda citrifolia), pointed gourd (Trichosanthes dioica), pumpkin (Cucurbita maxima), ridge gourd (Luffa acutangular), snake gourd (Trichosanthes cucumerina), spine gourd (Momordica dioica), and tomato (Solanum lycopersicum) have been presented. A complete picture of the nutritional qualities, phytochemical constituents, health benefits of these vegetable seeds, and their impact on the fortification of ready‐to‐eat foods have been illustrated. The development of functional food goods (bakery products, milk products, cereal‐based products, and meat products) from food waste (vegetable seeds) is extensively discussed in this study. It also highlights possible research gaps related to this field. Novelty impact statement Waste management is a key challenge to achieve the goal of sustainable development, particularly for the vegetable processing industries. Vegetable seeds contribute a hefty share in food waste generation and can be valorized as a food fortification and/or preservation agent.

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“…Benincasa hispida is a widely used vegetable in China, which belongs to the Cucurbitaceae family. It is also used as vegetable in many countries for the treatment of many diseases such as respiratory, gastrointestinal, diabetes mellitus, heart, and urinary diseases (Arora & Kaushik, 2016; Lim, 2012). Benincasa hispida (wax gourd) has been used in traditional Chinese medicine for the treatment of inflammation and hypertension (Huang et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Benincasa hispida extracts positively regulated high salt‐induced hypertension in Dahl salt‐sensitive rats: Impact on biochemical profile and metabolic patterns

Ahmad

Zhao

Ahmad

et al. 2022

Journal of Food Biochemistry

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Salt‐induced hypertension is one of the major issues worldwide and one of the main factors involved in heart and kidney failure. The objective of this study was to investigate the potential role of Benincasa hispida extracts on high salt‐induced hypertension in Dahl‐salt sensitive (D‐SS) rats and to find out the metabolic and biochemical pattern involved in the reduction of hypertension. Twenty‐six Dahl salt‐sensitive (D‐SS) rats were selected and divided into four groups. The metabolic strategy was applied to test the extracts on salt‐sensitive hypertension in kidney. Gas Chromatography–Mass spectrometry (GC–MS) was used to identify the potent biochemical profile in renal medulla and cortex of rat kidneys. The differential metabolites of cortex and medulla, enrichment analysis and pathway analysis were performed using metabolomics data. The GC–MS data revealed that 24 different antihypertensive metabolites was detected in renal cortex, while 16 were detected in renal medulla between different groups. The significantly metabolic pathways namely citrate cycle, glutathione metabolism, glycine, serine, and threonine metabolism, glyoxylate and dicarboxylate metabolism, glycerolipid metabolism, alanine, aspartate and glutamate metabolism in renal cortex and glycerolipid metabolism, pentose phosphate pathway, citrate cycle, glycolysis, glycerophospholipid metabolism, phenylalanine, tyrosine and tryptophan biosynthesis in renal medulla were involved in the process of Hypertension. The results suggest that the extract mainly alter the metabolic pathways of amino acid in Dahl salt‐sensitive rats and its antioxidant potential reduced the hypertension patterns of Salt‐sensitive rat. The antihypertensive components malic acid, aspartic acid, and glycine of extract can be used as therapeutic drugs to protect kidneys from salt‐induced hypertension. Practical applications Hypertension is a multifactorial disease and one of the risk factors for heart and kidney failure. Benincasa hispida is a widely used vegetable in China, which belongs to the Cucurbitaceae family. Benincasa hispida (wax gourd) has been used in traditional Chinese medicine for the treatment of inflammation and hypertension. The Benincasa hispida contains many compounds such as amino acids, carbohydrates, volatile compounds, vitamins, and minerals. The amino acid present in the pulp of Benincasa hispida are ornithine, threonine, aspartate, glutamate, serine, glycine, proline, alanine, valine, cysteine, isoleucine, tyrosine, leucine, lysine, phenylalanine, histidine, arginine, and γ‐aminobutyric acid. Our results showed that Benincasa hispida is one of the potent natural antioxidants and can maintain normal blood pressure in Dahl salt‐sensitive rats (D‐SS). In conclusion, the current results provide good theoretical basis for the development and research using Benincasa hispida as an effective natural antioxidant for hypertension.

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Therapeutic potential of Benincasa cerifera: A review

Cited by 6 publications

References 38 publications

Therapeutic Applications of Biostable Silver Nanoparticles Synthesized Using Peel Extract of Benincasa hispida: Antibacterial and Anticancer Activities

Therapeutic Applications of Biostable Silver Nanoparticles Synthesized Using Peel Extract of Benincasa hispida: Antibacterial and Anticancer Activities

Vegetable seeds: A new perspective in future food development

Benincasa hispida extracts positively regulated high salt‐induced hypertension in Dahl salt‐sensitive rats: Impact on biochemical profile and metabolic patterns

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