Therapeutic potential of benzothiazoles: a patent review (2010 – 2014)

Abstract

Several molecules containing benzothiazole skeleton are agents of choice for the treatment of various human diseases/disorders. Its versatile character of being capable of serving as ligand to various biomolecules attracted the interest of medicinal chemists for the development of therapies for respective ailments, especially, the 2-arylbenzothiazole moiety which is under development for the treatment of cancer. This signifies the increasing importance of benzothiazole nucleus in the area of drug discovery. Its structural simplicity and ease of synthesis provides scope for the development of chemical libraries that could serve in the discovery of new chemical entities progressing towards the market.

Synthesis and Antimicrobial Evaluation of Some Tricyclic Substituted benzo[h]quinazolines, benzo[h]quinolines and naphthaleno[d]thiazoles

“…Moreover, benzothiazole fused heterocyclic scaffold has been reported to have a relatively variable pharmacological effects such as antimicrobial 34 , anticancer 35,36 , anti-inflammatory 37 , β-2 adrenoceptor agonist and antidepressant activities 38 . Figure 3 depicts some of benzothiazole-containing drugs like; the sulfonamide diuretic ethoxozolmide, the antiviral and immuno-suppressive frentizole, the glutamate receptor antagonist riluzole used in treatment of amyotrophic lateral sclerosis, the anti-diabetic zopolrestat and the amyloid imaging agent thioflavin T 38 .…”

“…Figure 3 depicts some of benzothiazole-containing drugs like; the sulfonamide diuretic ethoxozolmide, the antiviral and immuno-suppressive frentizole, the glutamate receptor antagonist riluzole used in treatment of amyotrophic lateral sclerosis, the anti-diabetic zopolrestat and the amyloid imaging agent thioflavin T 38 . Driven by the urgent need to develop novel antimicrobial agents of broader spectrum of activity, more potency and less toxicity and in the shade of the aforementioned facts, we were interested in the synthesis of some structurally related congener tricycles of …”

Podophyllotoxin derivatives: a patent review (2012 – 2014)

“…Due to their versatile biological profiles these scaffolds have attracted great interest in the development of chemical libraries, which serve as one of the key sources for the identification of drug candidates. This is evident from the number of patents that have been granted in the past few years discussing the biological activities of heterocycles [42,43]. In view of this Mei et al have patented DEPPT-based furan derivatives as antitumor agents [44].…”

Insight into the interaction of benzothiazole tethered triazole analogues with human serum albumin: Spectroscopy and molecular docking approaches

“…The benzothiazole scaffold is a component of several successful clinical drugs such as ethoxzolamide (sulphonamide drug serves as diuretic), frentizole (urea derivative of benzothiazole as antiviral and immunosuppressive), riluzole (glutamate receptor antagonist to treat amyotrophic lateral sclerosis, anxiety disorder), zopolrestat (antidiabetic), thioflavin (amyloid imaging agent), and pramipexole (Parkinson's disease) (Figure ). These scaffolds are also vital in polymer chemistry, in dyes and pigment industries …”