Therapeutic potential of camel milk exosomes against HepaRG cells with potent apoptotic, anti-inflammatory, and anti-angiogenesis effects for colostrum exosomes

Elkattawy, Azza M.; Algezawy, Ola; Alfaifi, Mohammad Y.; Noseer, Enas A.; Hawsawi, Yousef M.; Alzahrani, Othman R.; Algarni, Abdulrahman; Kahilo, Khaled; El-Magd, Mohammed A.

doi:10.1016/j.biopha.2021.112220

Cited by 38 publications

(49 citation statements)

References 59 publications

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“…These carcinogenic suppression effects are attained by elevation in the expression level of both Bax and caspase3 and reduction in Bcl2 level. This was accompanied by a reduced expression level of the inflammatory mediators such as TNFα, NFkB, TGFβ1, and Cox2 as well as the angiogenic-related factors VEGF [ 36 ].…”

Section: Exosomesmentioning

confidence: 99%

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Camels’ biological fluids contained nanobodies: promising avenue in cancer therapy

et al. 2022

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Cancer is a major health concern and accounts for one of the main causes of death worldwide. Innovative strategies are needed to aid in the diagnosis and treatment of different types of cancers. Recently, there has been an evolving interest in utilizing nanobodies of camel origin as therapeutic tools against cancer. Nanotechnology uses nanobodies an emerging attractive field that provides promises to researchers in advancing different scientific sectors including medicine and oncology. Nanobodies are characteristically small-sized biologics featured with the ability for deep tissue penetration and dissemination and harbour high stability at high pH and temperatures. The current review highlights the potential use of nanobodies that are naturally secreted in camels’ biological fluids, both milk and urine, in the development of nanotechnology-based therapy for treating different typesQuery of cancers and other diseases. Moreover, the role of nano proteomics in the invention of novel therapeutic agents specifically used for cancer intervention is also illustrated.

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Section: Exosomesmentioning

confidence: 99%

“…Nanobodies were reported in camels in the early 1980s, the presence of which makes camels unique. Importantly, camel milk contains nanobodies that potentially can be used as a promising tool for diagnosing and targeting metastatic cancers [36][37][38][39].…”

Section: Arabian Camel's Genome and Nanobodies Emergencementioning

confidence: 99%

Camels’ biological fluids contained nanobodies: promising avenue in cancer therapy

et al. 2022

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“…The anti-tumor impact may well be related to the stimulation of apoptosis, as well as the prevention of inflammatory and angiogenesis. The findings suggest that exosomes obtained from colostrum are more effective at inhibiting tumor growth in HepaRG cells compared with exosomes isolated from the other lactation periods [ 149 ].…”

Section: Extracellular Vesiclesmentioning

confidence: 99%

The Therapeutic Potential of Milk Extracellular Vesicles on Colorectal Cancer

Babaker

Aljoud

Alkhilaiwi

et al. 2022

IJMS

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Colorectal cancer remains one of the leading prevalent cancers in the world and is the fourth most common cause of death from cancer. Unfortunately, the currently utilized chemotherapies fail in selectively targeting cancer cells and cause harm to healthy cells, which results in profound side effects. Researchers are focused on developing anti-cancer targeted medications, which is essential to making them safer, more effective, and more selective and to maximizing their therapeutic benefits. Milk-derived extracellular vesicles (EVs) from camels and cows have attracted much attention as a natural substitute product that effectively suppresses a wide range of tumor cells. This review sheds light on the biogenesis, methods of isolation, characterization, and molecular composition of milk EVs as well as the therapeutic potentials of milk EVs on colorectal cancer.

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“…CM exosomes have also been reported to mitigate oxidative stress and immuno-toxic responses induced by the chemotherapeutic drug cyclophosphamide in an albino rat model [ 3 ]. Recently, El-Magd have envisaged the apoptotic, anti-inflammatory, and anti-angiogenesis properties of CM exosomes from colostrum against HepaRG cells [ 80 ].…”

Section: Pharmacological Properties Of CM Exosomesmentioning

confidence: 99%

Prospective Role of Bioactive Molecules and Exosomes in the Therapeutic Potential of Camel Milk against Human Diseases: An Updated Perspective

Khan

Ansari

Uddin

et al. 2022

Life

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Camel milk (CM) constitutes an important dietary source in the hot and arid regions of the world. CM is a colloidal mixture of nutritional components (proteins, carbohydrates, lipids, vitamins, and minerals) and non-nutritional components (hormones, growth factors, cytokines, immunoglobulins, and exosomes). Although the majority of previous research has been focused on the nutritional components of CM; there has been immense interest in the non-nutritional components in the recent past. Reckoning with these, in this review, we have provided a glimpse of the recent trends in CM research endeavors and attempted to provide our perspective on the therapeutic efficacy of the nutritional and non-nutritional components of CM. Interestingly, with concerted efforts from the research fraternities, convincing evidence for the better understanding of the claimed traditional health benefits of CM can be foreseen with great enthusiasm and is indeed eagerly anticipated.

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Therapeutic potential of camel milk exosomes against HepaRG cells with potent apoptotic, anti-inflammatory, and anti-angiogenesis effects for colostrum exosomes

Cited by 38 publications

References 59 publications

Camels’ biological fluids contained nanobodies: promising avenue in cancer therapy

Camels’ biological fluids contained nanobodies: promising avenue in cancer therapy

The Therapeutic Potential of Milk Extracellular Vesicles on Colorectal Cancer

Prospective Role of Bioactive Molecules and Exosomes in the Therapeutic Potential of Camel Milk against Human Diseases: An Updated Perspective

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