Therapeutic potential of cannabinoids in combination cancer therapy

Malhotra, Pratibha; Casari, Ilaria; Falasca, Marco

doi:10.1016/j.jbior.2020.100774

Cited by 25 publications

(14 citation statements)

References 280 publications

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“…Furthermore, it is potentially desirable for cannabinoids to work on several hallmarks of cancer at one point in time. Many pre-clinical studies report the anti-tumor activity of cannabinoids [31,72,106]. An important aspect of cannabinoid pharmacology is their selectivity towards cancer cells and not to the normal cells in the body.…”

Section: Discussionmentioning

confidence: 99%

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The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate Cancer

Singh

Nassar

Bachari

et al. 2021

Cancers

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Prostate cancer is the second most frequently occurring cancer diagnosed among males. Recent preclinical evidence implicates cannabinoids as powerful regulators of cell growth and differentiation. In this review, we focused on studies that demonstrated anticancer effects of cannabinoids and their possible mechanisms of action in prostate cancer. Besides the palliative effects of cannabinoids, research from the past two decades has demonstrated their promising potential as antitumor agents in a wide variety of cancers. This analysis may provide pharmacological insights into the selection of specific cannabinoids for the development of antitumor drugs for the treatment of prostate cancer.

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Section: Discussionmentioning

confidence: 99%

“…Cannabinoids are a new emerging class of pharmacological molecules that can exert their therapeutic effect against different tumors including prostatic cancer [13,[29][30][31][32]. They bind to specific biological macromolecules exerting different physiological and behavioural responses [14].…”

Section: Cannabinoids As Pharmacological Effectorsmentioning

confidence: 99%

The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate Cancer

Singh

Nassar

Bachari

et al. 2021

Cancers

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“…Cannabinoids act as blocking or suppressing agents in these mechanistic pathways against various cancer types, including breast, ovarian, cervical, lung, skin, colon, prostate, and brain cancers, as well as leukaemia [23,27]. Furthermore, studies since the late 1990s indicated that multiple cannabinoids, especially CBD and THC, initiate antitumour impacts in a vast range of in vitro to in vivo experiments on various cancer cells, individually, but also in combined administrations [18,28].…”

Section: Phytocannabinoids Therapeutic Effects Citationsmentioning

confidence: 99%

The Transdermal Delivery of Therapeutic Cannabinoids

et al. 2022

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Recently, several studies have indicated an increased interest in the scientific community regarding the application of Cannabis sativa plants, and their extracts, for medicinal purposes. This plant of enormous medicinal potential has been legalised in an increasing number of countries globally. Due to the recent changes in therapeutic and recreational legislation, cannabis and cannabinoids are now frequently permitted for use in clinical settings. However, with their highly lipophilic features and very low aqueous solubility, cannabinoids are prone to degradation, specifically in solution, as they are light-, temperature-, and auto-oxidation-sensitive. Thus, plant-derived cannabinoids have been developed for oral, nasal-inhalation, intranasal, mucosal (sublingual and buccal), transcutaneous (transdermal), local (topical), and parenteral deliveries. Among these administrations routes, topical and transdermal products usually have a higher bioavailability rate with a prolonged steady-state plasma concentration. Additionally, these administrations have the potential to eliminate the psychotropic impacts of the drug by its diffusion into a nonreactive, dead stratum corneum. This modality avoids oral administration and, thus, the first-pass metabolism, leading to constant cannabinoid plasma levels. This review article investigates the practicality of delivering therapeutic cannabinoids via skin in accordance with existing literature.

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“…Antineoplastic activity of cannabinoids demonstrated inhibition of growth of several cancer cell lines, and promising results have been obtained in animal cancer models (lung, breast and prostate and blood cancers). Nevertheless, highly heterogeneous cannabinoid receptor expression has been reported in several cancers, which it seems, are not ubiquitously expressed in all patients [ 17 ]. Regarding glioblastoma, the most frequent and aggressive malignant brain tumour, it found that elevated CB2 expression correlated with a higher degree of tumour malignancy.…”

Section: Pain and Role Of Cannabinoidsmentioning

confidence: 99%

Cannabinoid Formulations and Delivery Systems: Current and Future Options to Treat Pain

Stella

Baratta

Pepa

et al. 2021

Drugs

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The field of Cannabis sativa L. research for medical purposes has been rapidly advancing in recent decades and a growing body of evidence suggests that phytocannabinoids are beneficial for a range of conditions. At the same time impressing development has been observed for formulations and delivery systems expanding the potential use of cannabinoids as an effective medical therapy. The objective of this review is to present the most recent results from pharmaceutical companies and research groups investigating methods to improve cannabinoid bioavailability and to clearly establish its therapeutic efficacy, dose ranges, safety and also improve the patient compliance. Particular focus is the application of cannabinoids in pain treatment, describing the principal cannabinoids employed, the most promising delivery systems for each administration routes and updating the clinical evaluations. To offer the reader a wider view, this review discusses the formulation starting from galenic preparation up to nanotechnology approaches, showing advantages, limits, requirements needed. Furthermore, the most recent clinical data and meta-analysis for cannabinoids used in different pain management are summarized, evaluating their real effectiveness, in order also to spare opioids and improve patients’ quality of life. Promising evidence for pain treatments and for other important pathologies are also reviewed as likely future directions for cannabinoids formulations.

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Therapeutic potential of cannabinoids in combination cancer therapy

Cited by 25 publications

References 280 publications

The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate Cancer

The Pathophysiology and the Therapeutic Potential of Cannabinoids in Prostate Cancer

The Transdermal Delivery of Therapeutic Cannabinoids

Cannabinoid Formulations and Delivery Systems: Current and Future Options to Treat Pain

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