Therapeutic potential of castor oil in managing blepharitis, meibomian gland dysfunction and dry eye

Sandford, Emma C; Müntz, Alex; Craig, Jennifer P.

doi:10.1111/cxo.13148

Cited by 23 publications

(17 citation statements)

References 86 publications

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“…Castor oil is a natural derivative of the Ricinus communis plant that possesses anti-inflammatory, anti-nociceptive, antioxidant, and antimicrobial properties [43,[46][47][48]. Castor oil eye drops have been administered safely in several eye disorders like mild dry eye, blepharitis, contact lens discomfort, refractory Meibomian gland dysfunction [49][50][51].…”

Section: Discussionmentioning

confidence: 99%

Formulation and Stability of Ataluren Eye Drop Oily Solution for Aniridia

et al. 2020

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Congenital aniridia is a rare and severe panocular disease characterized by a complete or partial iris defect clinically detectable at birth. The most common form of aniridia occurring in around 90% of cases is caused by PAX6 haploinsufficiency. The phenotype includes ptosis, nystagmus, corneal limbal insufficiency, glaucoma, cataract, optic nerve, and foveal hypoplasia. Ataluren eye drops aim to restore ocular surface PAX6 haploinsufficiency in aniridia-related keratopathy (ARK). However, there are currently no available forms of the ophthalmic solution. The objective of this study was to assess the physicochemical and microbiological stability of ataluren 1% eye drop in preservative-free low-density polyethylene (LDPE) bottle with an innovative insert that maintains sterility after opening. Because ataluren is a strongly lipophilic compound, the formulation is complex and involves a strategy based on co-solvents in an aqueous phase or an oily formulation capable of totally dissolving the active ingredient. The visual aspect, ataluren quantification by a stability-indicating chromatographic method, and microbiological sterility were analyzed. The oily formulation in castor oil and DMSO (10%) better protects ataluren hydrolysis and oxidative degradation and permits its complete solubilization. Throughout the 60 days period, the oily solution in the LDPE bottle remained clear without any precipitation or color modification, and no drug loss and no microbial development were detected. The demonstrated physical and microbiological stability of ataluren 1% eye drop formulation at 22–25 °C might facilitate clinical research in aniridia.

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Section: Discussionmentioning

confidence: 99%

Formulation and Stability of Ataluren Eye Drop Oily Solution for Aniridia

et al. 2020

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“…Blepharitis is the anterior or posterior inflammation of eyelids, which can be subacute or chronic, caused by S. aureus and seborrheic bacteria [165]. Linezolid and vancomycin were reported to be most effective against the staphylococcus bacteria and overcame resistance towards penicillin, erythromycin, and ciprofloxacin [166]. The ocular barriers, such as involuntary eye muscle movement, tears, etc., remove foreign particles, including drugs, coming across the eye surface, which means that ocular drugs require frequent administration.…”

Section: Vancomycin-loaded Thiolated Nanocarriersmentioning

confidence: 99%

Amino Acids, Peptides, and Proteins: Implications for Nanotechnological Applications in Biosensing and Drug/Gene Delivery

Laraib

Arshad

et al. 2021

Nanomaterials

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Over various scientific fields in biochemistry, amino acids have been highlighted in research works. Protein, peptide- and amino acid-based drug delivery systems have proficiently transformed nanotechnology via immense flexibility in their features for attaching various drug molecules and biodegradable polymers. In this regard, novel nanostructures including carbon nanotubes, electrospun carbon nanofibers, gold nanoislands, and metal-based nanoparticles have been introduced as nanosensors for accurate detection of these organic compounds. These nanostructures can bind the biological receptor to the sensor surface and increase the surface area of the working electrode, significantly enhancing the biosensor performance. Interestingly, protein-based nanocarriers have also emerged as useful drug and gene delivery platforms. This is important since, despite recent advancements, there are still biological barriers and other obstacles limiting gene and drug delivery efficacy. Currently available strategies for gene therapy are not cost-effective, and they do not deliver the genetic cargo effectively to target sites. With rapid advancements in nanotechnology, novel gene delivery systems are introduced as nonviral vectors such as protein, peptide, and amino acid-based nanostructures. These nano-based delivery platforms can be tailored into functional transformation using proteins and peptides ligands based nanocarriers, usually overexpressed in the specified diseases. The purpose of this review is to shed light on traditional and nanotechnology-based methods to detect amino acids, peptides, and proteins. Furthermore, new insights into the potential of amino protein-based nanoassemblies for targeted drug delivery or gene transfer are presented.

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“…An eye drop containing the oil of Ricinus Communis is generally used to cure dry eyes, inflammation, redness, swelling, and watery eyes. Various allopathic drugs such as carboxymethyl cellulose, sodium hyaluronate, polyethylene glycol 400 are some common eye lubricants that can treat eye ailments and dryness 45,46 .…”

Section: Antimicrobialmentioning

confidence: 99%

Untitled

2021

IJPSR

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The medicinal plant Ricinus communis is one of the effective plants which offer a solution to several kinds of diseases. Owing to this, the present research aims to review the medicinal properties of one of such common herbal plants, Ricinus communis, its possible role as herbal medicine, and assessment for pharmacovigilance. Related research articles were collected from Google Scholar, Pub Med, Science direct, Scientific information Database, and Scopus. For the present study purpose, using the term Ricinus communis, the castor bean, and castor oil plant in the title of all articles published to 2021 were observed. Phytochemical constituents of R. communis like saponins, flavonoids, alkaloids, steroids, and glucosides. Leaves of the plant have shown the presence of major phenolic compounds. Whereas roots test has presented the Indole-3acetic. The findings reflect that the plant contains high medicinal benefits, which offer a solution for several kinds of diseases like cancer, diabetes, ulcer and anthelmintic, etc. Also, the plant is antiinflammatory property of the plant facilitates therapeutic use. Therefore, all parts of the medicinal plant R. communis are considered highly beneficial in the medicinal field.INTRODUCTION: Herbal plants have always been a viable source of medicine since prehistoric ages. Some of the isolated rural areas of developing and underdeveloped countries are still unable to get synthetic drugs easily. Traditional medicinal plants being easily available are used by many people to treat numerous illnesses. In India, 65-70% of the rural population rely on medicinal plants in the form of various indigenous ethnic systems like Ayurveda, Siddha, Unani, etc.

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Therapeutic potential of castor oil in managing blepharitis, meibomian gland dysfunction and dry eye

Cited by 23 publications

References 86 publications

Formulation and Stability of Ataluren Eye Drop Oily Solution for Aniridia

Formulation and Stability of Ataluren Eye Drop Oily Solution for Aniridia

Amino Acids, Peptides, and Proteins: Implications for Nanotechnological Applications in Biosensing and Drug/Gene Delivery

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