Therapeutic Potential of Chitosan and Its Derivatives in Regenerative Medicine

Chen, Shi; Zhu, Ying; Ran, Xinze; Wang, Meng; Su, Yongping; Cheng, Tianmin

doi:10.1016/j.jss.2005.12.013

Cited by 480 publications

(313 citation statements)

References 64 publications

(86 reference statements)

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“…It readily forms hydrogels that have been used in a number of gene and drug delivery and tissue engineering. 27,28 Alginate has been also used extensively in hydrogel form for cell encapsulation and drug delivery, 29 as well as in tissue engineering. 30 Although many advances in alginatebased materials have been reported, translation to clinical applications will require several improvements.…”

Section: Polymeric Biomaterialsmentioning

confidence: 99%

Recent Applications of Polymeric Biomaterials and Stem Cells in Tissue Engineering and Regenerative Medicine

Lee

Yoo

Atala³

2014

Polymer Korea

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Tissue engineering and regenerative medicine strategies could offer new hope for patients with serious tissue injuries or end-stage organ failure. Scientists are now applying the principles of cell transplantation, material science, and engineering to create biological substitutes that can restore and maintain normal function in diseased or injured tissues/ organs. Specifically, creation of engineered tissue construct requires a polymeric biomaterial scaffold that serves as a cell carrier, which would provide structural support until native tissue forms in vivo. Even though the requirements for scaffolds may be different depending on the target applications, a general function of scaffolds that need to be fulfilled is biodegradability, biological and mechanical properties, and temporal structural integrity. The scaffold's internal architecture should also enhance the permeability of nutrients and neovascularization. In addition, the stem cell field is advancing, and new discoveries in tissue engineering and regenerative medicine will lead to new therapeutic strategies. Although use of stem cells is still in the research phase, some therapies arising from tissue engineering endeavors that make use of autologous adult cells have already entered the clinic. This review discusses these tissue engineering and regenerative medicine strategies for various tissues and organs.

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Section: Polymeric Biomaterialsmentioning

confidence: 99%

Recent Applications of Polymeric Biomaterials and Stem Cells in Tissue Engineering and Regenerative Medicine

Lee

Yoo

Atala³

2014

Polymer Korea

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“…Quando a desacetilação da quitina é superior a 65%-60%, o co-polímero resultante é a quitosana (AZEVEDO et al, 2007;SANTOS;FERREIRA, 2006;SINGLA;CHAWLA, 2001;SHI et al, 2006).…”

Section: Propriedades Físico-químicas Da Quitinaunclassified

“…A quitosana é insolúvel em água em pH alcalino e neutro e solúvel em pH ácido (SINGLA; CHAWLA, 2001;SHI et al, 2006). Em ácidos diluídos (pH<5,5), os grupamentos amino livres são protonados e a molécula se torna solúvel (SHI et al, 2006).…”

Section: Propriedades Físico-químicas Da Quitosanaunclassified

“…Em ácidos diluídos (pH<5,5), os grupamentos amino livres são protonados e a molécula se torna solúvel (SHI et al, 2006).…”

Section: Propriedades Físico-químicas Da Quitosanaunclassified

“…A quitosana ativa macrófagos e neutrófilos e acelera a migração deles para o local da lesão. (SHI et al, 2006;UENO et al, 1999UENO et al, , 2001. Os macrófagos ativados liberam Interleucina-1, que estimula a proliferação de fibroblastos e influencia a estrutura do colágeno.…”

Section: Outras Aplicações Da Quitosanaunclassified

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Síntese e avaliações físico-químicas e biológicas de derivados de quitosana de alta e baixa massa molecular

Bezerra¹

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Delivery Systems For Peptides/Oligonucleotides And Lipophilic Nucleoside Analogs

Schwendener¹,

Schott²

2010

Pharmaceutical Sciences Encyclopedia

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Drug delivery systems (DDS) are developed for drugs with nonideal properties, such as poor solubility, tissue damage, and loss of drug activity after administration. The formulation of pharmacologically active drug molecules in DDS can improve or abolish toxic side effects and suboptimal therapeutic effects. This article focuses on DDSs for the delivery of peptides, DNA, plasmids, oligodeoxynucleotides, siRNA, and lipophilic nucleoside derivatives.

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Therapeutic Potential of Chitosan and Its Derivatives in Regenerative Medicine

Cited by 480 publications

References 64 publications

Recent Applications of Polymeric Biomaterials and Stem Cells in Tissue Engineering and Regenerative Medicine

Recent Applications of Polymeric Biomaterials and Stem Cells in Tissue Engineering and Regenerative Medicine

Síntese e avaliações físico-químicas e biológicas de derivados de quitosana de alta e baixa massa molecular

Delivery Systems For Peptides/Oligonucleotides And Lipophilic Nucleoside Analogs

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