Therapeutic potential of Curcuma oil and its terpenoids in gynecological cancers

Zhang, Yuan; Peng, Fu; Yu, Chenghao

doi:10.1016/j.biopha.2022.114016

Cited by 14 publications

(7 citation statements)

References 82 publications

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“…They are classified based on the number of isoprene units in the molecular structure, including monoterpenes, sesquiterpenes, diterpenes, triterpenes, and tetraterpenes. Each isoform has different biological activities, with some having anti-cancer effects (Wei et al 2023 ; Zhang et al 2023 ). Zerumbone (Lv et al 2018 ) is a monocyclic sesquiterpenoid compound that is isolated from the root of Zingiber Zerumbet Smith.…”

Section: Natural Product-targeted Mapk-signaling Pathway For Cancer P...mentioning

confidence: 99%

Natural products targeting the MAPK-signaling pathway in cancer: overview

Shi,

Liu,

et al. 2024

J Cancer Res Clin Oncol

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Purpose This article summarizes natural products that target the MAPK-signaling pathway in cancer therapy. The classification, chemical structures, and anti-cancer mechanisms of these natural products are elucidated, and comprehensive information is provided on their potential use in cancer therapy. Methods Using the PubMed database, we searched for keywords, including “tumor”, “cancer”, “natural product”, “phytochemistry”, “plant chemical components”, and “MAPK-signaling pathway”. We also screened for compounds with well-defined structures that targeting the MAPK-signaling pathway and have anti-cancer effects. We used Kingdraw software and Adobe Photoshop software to draw the chemical compound structural diagrams. Results A total of 131 papers were searched, from which 85 compounds with well-defined structures were selected. These compounds have clear mechanisms for targeting cancer treatment and are mainly related to the MAPK-signaling pathway. Examples include eupatilin, carvacrol, oridonin, sophoridine, diosgenin, and juglone. These chemical components are classified as flavonoids, phenols, terpenoids, alkaloids, steroidal saponins, and quinones. Conclusions Certain MAPK pathway inhibitors have been used for clinical treatment. However, the clinical feedback has not been promising because of genomic instability, drug resistance, and side effects. Natural products have few side effects, good medicinal efficacy, a wide range of sources, individual heterogeneity of biological activity, and are capable of treating disease from multiple targets. These characteristics make natural products promising drugs for cancer treatment.

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Section: Natural Product-targeted Mapk-signaling Pathway For Cancer P...mentioning

confidence: 99%

Natural products targeting the MAPK-signaling pathway in cancer: overview

Shi,

Liu,

et al. 2024

J Cancer Res Clin Oncol

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“…As a major constituent of the plant Rhizoma Curcumae, curcumol is low-toxic to the normal ovary and important organs [9][10][11]. It can reduce chemotherapy resistance and improve immunosuppression of cancer cells, which indicates that it is a potential drug candidate for MT [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…Clinically, curcumol has been regarded as a sensitizer or an adjuvant chemotherapy drug for OC [10]. Although curcumol has been proven to be effective against gynecological tumors [10,14], its low bioavailability, rapid metabolism, and poor enrichment in tumor regions restrain its broad use for OC treatment [15]. Polymeric micelles (PMs) can load hydrophobic drugs in the micellar hydrophobic core, and the drug can be protected by the outer hydrophilic corona, which can further prevent micelles from being eliminated by the mononuclear phagocytic system (MPS) in physical circulation, thereby prolonging the in vivo circulation time [16].…”

Section: Introductionmentioning

confidence: 99%

“…It can reduce chemotherapy resistance and improve immunosuppression of cancer cells, which indicates that it is a potential drug candidate for MT [12,13]. Clinically, curcumol has been regarded as a sensitizer or an adjuvant chemotherapy drug for OC [10]. Although curcumol has been proven to be effective against gynecological tumors [10,14], its low bioavailability, rapid metabolism, and poor enrichment in tumor regions restrain its broad use for OC treatment [15].…”

Section: Introductionmentioning

confidence: 99%

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Micellar Curcumol for Maintenance Therapy of Ovarian Cancer by activating the FOXO3a

Wang,

Chen,

Yang

et al. 2024

Preprint

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Background: Maintenance therapy (MT) after postoperative platinum-based chemotherapy for ovarian cancer (OC) is crucial for delaying or preventing disease relapse. The current targeted drugs are only effective in about 30% of OC patients and the options for MT are limited. FOXO3a was considered as a potential target of chemotherapeutic drugs for OC due to its key role in inhibiting disease progression and recurrence. Curcumol, a major constituent of the plant Rhizoma Curcumae, is a low-toxic and effective anti-cancer drug which indicates that it is a potential candidate for MT. However, curcumol is indissolubility in water, with low bioavailability, and its pharmacological basis is unclear. Herein, Micellar curcumol (MC) was prepared for the therapy of OC. Parallel assessments of the anti-tumor ability and mechanism of MC were performed on two kinds of OC cells. Results: The results indicated that the IC50 of MC in two OC cells were as low as 37.69±2.43 and 28.54±1.58 μg/mL, respectively. Curcumol, by inhibiting phosphorylation at the AKTT308 site, activates the transcriptional activity of FOXO3a, which further promotes the recruitment of FOXO3a to the promoter sequence of endoplasmic reticulum stress-related PERK genes, inducing OC cells apoptosis. Moreover, the DiR-labeled MC could quickly accumulate in the tumor region within only 1h and maintain for 48 h in vivo. Further, MC inhibited the growth of SKOV3 cells on tumor-bearing nude mice by intravenous injection. Conclusions: Micellar loaded curcumol provides great feasibility to achieve efficient MT for OC based on the nanoplatforms of active ingredients from natural products.

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“…Numerous anticancer drugs used in clinics today are either from natural or derived natural products, including plants [ 6 ] and microorganisms [ 7 , 8 ]. Among them, Curcuma oil or also known as turmeric oil (TO), derived from the rhizome of Curcuma longa from the ginger family, has been proven through the years to have pharmacologic activities including anticancer activity [ 9 ]. The major component of TO, ar -turmerone was found to have induced apoptosis accompanied by reactive oxygen species (ROS) production [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Folic Acid-Grafted Chitosan-Alginate Nanocapsules as Effective Targeted Nanocarriers for Delivery of Turmeric Oil for Breast Cancer Therapy

et al. 2022

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Folate receptors (FRs) highly expressed in breast cancers can be used as a recognized marker for preventing off-target delivery of chemotherapeutics. In this study, folic acid (FA)-grafted chitosan-alginate nanocapsules (CS-Alg-NCs) loaded with turmeric oil (TO) were developed for breast cancer targeting. CS was successfully conjugated with FA via an amide bond with a degree of substitution at 12.86%. The TO-loaded FA-grafted CS-Alg-NCs (TO-FA-CS-Alg-NCs) optimized by Box-Behnken design using response surface methodology had satisfactory characteristics with homogenous particle size (189 nm) and sufficient encapsulation efficiency and loading capacity (35.9% and 1.82%, respectively). In vitro release study of the optimized TO-FA-CS-Alg-NCs showed a sustained TO release following the Korsmeyer-Peppas model with a Fickian diffusion mechanism at pH 5.5 and 7.4. The TO-FA-CS-Alg-NCs showed lower IC50 than ungrafted TO-CS-Alg-NCs and unencapsulated TO against MDA-MB-231 and MCF-7 breast cancer cells, suggesting that FA-CS-Alg-NCs can improve anticancer activity of TO through its active targeting to the high FRs expressing breast cancers.

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Therapeutic potential of Curcuma oil and its terpenoids in gynecological cancers

Cited by 14 publications

References 82 publications

Natural products targeting the MAPK-signaling pathway in cancer: overview

Natural products targeting the MAPK-signaling pathway in cancer: overview

Micellar Curcumol for Maintenance Therapy of Ovarian Cancer by activating the FOXO3a

Folic Acid-Grafted Chitosan-Alginate Nanocapsules as Effective Targeted Nanocarriers for Delivery of Turmeric Oil for Breast Cancer Therapy

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