Therapeutic potential of flavonoid-rich plants in the treatment of arterial hypertension and diabetes mellitus: focus on antioxidant role

Silva, Matheus Vinicius Barbosa da; Barbosa, Gleyciele dos Santos; Rocha, Alisson Carlos da; Rocha, Diego da; Silva, Thais Ana da; Silva, Jackson Alves da; Andrade, Alyssa Castelo Branco Alencar; Andrade, Bruna Bezerra Pimentel; Santos, Francisco Antonio da Cruz dos; Longen, Jonas Laerte; Silva, Heverton Valentim Colaço da

doi:10.33448/rsd-v11i8.31364

Cited by 2 publications

(1 citation statement)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, reports of serious liver damage have also been recounted (gov, 2017). Garlic (Allium sativum L.) has anti-obesity, antibacterial, antihypertensive, blood glucose-lowering, antithrombotic, antimutagenic, and antiplatelet effects, among other pharmacological effects [7][8][9][10][11]. Garlic oil and the organosulfur compounds it contains have been revealed to be useful for preventing rats on high-fat diets (HFDs) from increasing in weight [12].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Efficacy of Fermented Garlic and Orlistat (Lipase Inhibitor) in Obesity Management Using an Experimental Rodent Model

Javed,

Ahmed,

Khan

et al. 2023

Foods

View full text Add to dashboard Cite

Background: Black garlic, also known as fermented garlic, is a useful food that may have therapeutic benefits. The aim of this study was to analyze the impact of fermented garlic and orlistat therapy on obese rats. Methods: A total of 40 male albino rats (245–250 g) were fed either an HFD (n = 32) or a normal diet (n = 8) for 6 weeks; therefore we randomly assigned the rats into: group I (normal diet), group II (HFD), groups III and IV (HFD with fermented garlic), and group V (orlistat for) 6 weeks. Two different dosages of fermented garlic (481.2 mg/kg and 963.3 mg/kg) were administered. Afterward, blood was collected, body weight was measured, and tissue was collected for further analysis. Results: Both the orlistat and black garlic groups showed a significant reduction in BMI, lipid profiles, and insulin levels compared with the baseline. The orlistat group showed significant elevation (p < 0.005) in body weight, organ weight, lipids, and liver parameters, with histopathological findings. The administration of black garlic improved the inflammatory markers with all other parameters. Conclusion: The fermented garlic and orlistat reinstated all of the investigated parameters significantly (p < 0.05), especially body weight and lipid profiles, and induced histopathological changes compared to the drug orlistat. Additionally, it showed anti-obesity-related therapeutic impacts compared with the orlistat drug. Black garlic provides a reliable and effective treatment for obesity compared to orlistat.

show abstract

Section: Introductionmentioning

confidence: 99%

Comparison of Efficacy of Fermented Garlic and Orlistat (Lipase Inhibitor) in Obesity Management Using an Experimental Rodent Model

Javed,

Ahmed,

Khan

et al. 2023

Foods

View full text Add to dashboard Cite

show abstract

Safety classification of herbal medicine use among hypertensive patients: a systematic review and meta-analysis

Choi,

Im,

Choi

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

BackgroundThe use of herbal medicines (HMs) for the treatment of hypertension (HTN) is increasing globally, but research on the potential adverse effects and safety of HMs in HTN patients is limited. Therefore, this systematic review and meta-analysis aim to determine the global prevalence of HM usage among HTN patients and assess the safety of identified herbs based on current scientific evidence.MethodsThe PubMed/MEDLINE, EMBASE (Ovid), and Cumulated Index to Nursing and Allied Health Literature (CINAHL) databases were searched for cross-sectional studies on the use of HM among HTN patients. Our review includes studies published in English up to the year 2023. After extracting and appraising the data from the studies, a meta-analysis was conducted using the Stata version 16.0 to estimate the pooled prevalence of HM use in patients with HTN (PROSPERO: CRD42023405537). The safety classification of the identified HM was done based on the existing scientific literature.ResultsThis study analyzed 37 cross-sectional studies from 21 countries and found that 37.8% of HTN patients used HM to manage their health. The prevalence of HM use varied significantly based on publication year and geographical region. Among the 71 identified herbs, Allium sativum L., Hibiscus sabdariffa L., and Olea europaea L. were the most commonly used. However, four herbs were identified as contraindicated, 50 herbs required caution, and only 11 herbs were considered safe for use.ConclusionThe study highlights the potential risks of toxicities and adverse effects associated with HM use in the treatment of HTN. Ensuring patient safety involves using safe HMs in appropriate doses and avoiding contraindicated HMs. Future research should focus on identifying commonly used herbs, especially in resource-limited countries with poor HTN management, and additional clinical research is required to assess the toxicity and safety of commonly used HMs.

show abstract

Therapeutic potential of flavonoid-rich plants in the treatment of arterial hypertension and diabetes mellitus: focus on antioxidant role

Cited by 2 publications

References 54 publications

Comparison of Efficacy of Fermented Garlic and Orlistat (Lipase Inhibitor) in Obesity Management Using an Experimental Rodent Model

Comparison of Efficacy of Fermented Garlic and Orlistat (Lipase Inhibitor) in Obesity Management Using an Experimental Rodent Model

Safety classification of herbal medicine use among hypertensive patients: a systematic review and meta-analysis

Contact Info

Product

Resources

About