Therapeutic potential of follistatin for colonic inflammation in mice

Dohi, Taeko; Ejima, Chieko; Kato, Rie; Kawamura, Yuki I.; Kawashima, Rei; Mizutani, Noriko; Tabuchi, Yoshiaki; Kojima, Itaru

doi:10.1053/j.gastro.2004.11.063

Cited by 92 publications

(71 citation statements)

References 33 publications

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“…In our analysis, we can observe that BMD correlated strongly and negatively with circulating follistatin in univariate and multivariate analysis. Finally, animal studies have recently demonstrated an anti-inflammatory potential of follistatin in LPS-induced systemic inflammation (29), chemical-induced colonic inflammation (30), and vascular inflammation triggered by oscillatory shear stress (31). In accordance with one report showing a direct association between CRP levels and follistatin in women with polycystic ovary syndrome (32), we found that inflamed patients exhibited the highest follistatin levels.…”

Section: Discussionsupporting

confidence: 90%

Circulating Follistatin in Patients with Chronic Kidney Disease

Miyamoto

Carrero

Qureshi

et al. 2011

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Follistatin mediates muscle growth and bone mineralization. At present, it is unknown whether circulating follistatin levels are altered in chronic kidney disease (CKD) or links to CKD risk factors and outcomes.Design, setting, participants, & measurements Plasma follistatin levels were cross-sectionally analyzed in relation to protein-energy wasting (PEW), handgrip strength (HGS), bone mineral density (BMD), and inflammatory markers in 280 CKD stage 5 patients, 32 CKD stage 4 patients, 16 CKD stage 3 patients, and 32 control subjects. In CKD stage 5 patients survival was prospectively investigated during a follow-up period of up to 5 years. ResultsThe plasma follistatin concentration was not higher in CKD stage 5 patients than in other CKD stages or controls. In CKD stage 5 patients, circulating follistatin positively correlated with age, high-sensitivity C-reactive protein (hsCRP), and IL-6; negatively correlated with HGS, serum creatinine, and BMD; and was increased in patients with PEW. In a multivariate logistic regression model, lower HGS, lower BMD, and higher hsCRP independently correlated with higher follistatin levels. In a Cox regression model, follistatin levels were not associated with all-cause mortality.Conclusions Circulating follistatin levels were neither elevated nor predicted outcome in patients with CKD. However, increased follistatin levels occurred together with increased inflammation, reduced muscle strength, and low BMD, suggesting an involvement of a mechanism including follistatin in the uremic wasting process.

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Section: Discussionsupporting

confidence: 90%

Circulating Follistatin in Patients with Chronic Kidney Disease

Miyamoto

Carrero

Qureshi

et al. 2011

Clinical Journal of the American Society of Nephrology

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“…In addition to organs described above, the activinfollistatin system is also involved in various disorders in other tissues. For example, activin plays a critical role in colonic inflammation and follistatin has a therapeutic potential to treat inflammatory bowel diseases (50). In addition, activin A is involved in angiogenesis and follistatin may be useful to inhibit pathological angiogenesis (51,52).…”

Section: Lungmentioning

confidence: 99%

Therapeutic Potential of Follistatin to Promote Tissue Regeneration and Prevent Tissue Fibrosis

Aoki

Kojima

2007

Endocr J

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“…Follistatin, which is structurally unrelated to the TGF-␤ superfamily, binds activin A with high affinity and blocks the ability of activin A to bind to its receptor and initiate downstream signaling (36). Animal studies show that injection of exogenous follistatin can improve survival following septic shock (13) and reduces the severity of inflammation and subsequent damage in diseases, like colitis and allergic asthma, and in experimental lung and liver damage models (2,7,9,27).…”

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confidence: 99%