Therapeutic Potential of Glioblastoma Stem Cells

Abstract

Primary and the secondary GBM, these are the two distinct disease entity. The genetic and the epigenetic background of these tumors are highly variable and the treatment procedure of these tumors is not curable because of the cellular heterogeneity and intrinsic ability of the tumor cells to invading healthy tissues. The fatal outcomes of these tumors promote the researchers to find out new markers associated with prognosis and treatment planning. Here we summarized the roles of glioblastoma stem cells in tumor progression and malignant behaviors of GBMs with attention to signaling pathways and molecular regulator involved in maintaining the glioblastoma stem cell phenotype. A better understanding of these stem-like cells is necessary for designing new effective treatments and developing novel molecular strategies to targeting glioblastoma stem cells treatment for these patients.