Therapeutic Potential of Growth Factors for Aging Voice

Hirano, Shigeru; Bless, Diane M.; Río, Alejandro Muñoz del; Connor, Nadine P.; Ford, Charles N.

doi:10.1097/01.mlg.0000149450.37640.db

Cited by 86 publications

(101 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The stress σ is the applied force F max per unit area A given by (8) The resultant strain ε is given by tangential displacement X max per material thickness H. (9) Shear modulus G is defined as stress per unit strain (10) (11) As DSR = F max / X max then (12) The thickness of the adult human vocal fold lamina propria is typically 1 mm [26], which is the figure used for H. The area of attachment is obtained by measuring the bore of the suction attachment, which in this study was 2 mm.…”

Section: Methodsmentioning

confidence: 99%

“…Current approaches involve the use of hyaluronic acid implants, [2,3,4,5,6] growth factors [7,8,9,10] and mesenchymal stem cells [11,12] to stimulate tissue regeneration and improve wound healing outcomes. The ability to measure the biomechanical properties of the vocal fold without dissecting it out of anatomical context, is an essential pre-requisite to determining the viability of any new tissue repair technique.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Shear Modulus of the Human Vocal Fold in a Transverse Direction

et al. 2009

View full text Add to dashboard Cite

Objectives-To measure the shear modulus of the vocal fold in a human hemi-larynx, such that the data can be related to direction of applied stress and anatomical context.Methods-Dynamic spring rate data were collected using a modified Linear Skin Rheometer (LSR) using human hemi-larynges, and converted to estimated shear modulus via application of a simple shear model. The measurement probe was attached to the epithelial layer of the vocal fold cover using suction. A sinusoidal force of 3 g was applied to the epithelium, and the resultant displacement logged at a rate of 1 kHz. Force measurement accuracy was 20 μg, position measurement accuracy was 4 μm. The force was applied in a transverse direction at the mid-membranous point between the vocal process and the anterior commissure.Results-The shear modulus of the 3 female vocal folds ranged from 814 to 1232 Pa. The shear modulus of the 3 male vocal folds ranged from 1021 to 1796 Pa.Conclusions-These data demonstrate that it is possible to obtain estimates for the shear modulus of the vocal fold while preserving anatomical context. The modulus values reported here are higher than those reported using parallel plate rheometry. This is to be expected as the tissue is attached to surrounding structures, and is under natural tension.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Shear Modulus of the Human Vocal Fold in a Transverse Direction

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Growth factors are capable of regulating fibroblast activity, and the ones that have been shown to regulate the extracellular matrix balance in the vocal cords are the basic fibroblast growth factor (bFGF), which stimulates fibroblast growth and modulates extracellular matrix synthesis, and the hepatocyte growth factor, which plays an important role in tissue regeneration and exerts strong antifibrotic activity for reducing the production of type I collagen in the fibroblasts and increasing the production of hyaluronic acid [16][17][18][19] . The bFGF has been shown to stimulate the synthesis of hyaluronic acid and the growth of 'old' fibroblasts [20] ; on the other hand, the effects of the hepatocyte growth factor vary according to the concentration of the growth factor itself [20] . In 2003, Hirano et al [17][18][19] demonstrated that vocal cord fibroblasts cultivated in vitro were capable of increasing hyaluronic acid synthesis when stimulated by growth factors such as epidermal growth factor, transforming growth factor-␤ 1 , hepatocyte growth factor and bFGF.…”

Section: Discussionmentioning

confidence: 99%

Sex Hormone Receptors in Vocal Fold Tissue: A Theory about the Influence of Sex Hormones in the Larynx

Nacci¹,

Fattori²,

Basolo

et al. 2010

Folia Phoniatr Logop

View full text Add to dashboard Cite

Objective: The larynx is considered a secondary sexual organ. To demonstrate that sex hormones can directly influence laryngeal function, specific receptors in the vocal cord must be identified. Materials and Methods: We searched for estrogen, progesterone and androgen receptors, using an immunohistochemical method, in normal human vocal cords (from 3 cadavers) and in samples of healthy vocal cords and of laryngeal carcinomas from 15 live subjects. Breast and prostate carcinoma were used as controls. Results: In all the normal samples tested, the results were negative; there was only a nonspecific cytoplasmatic response in the subepithelial glands (false positives). In the neoplastic tissue, 2 samples had a weak nuclear focal positivity for estrogen and progesterone receptors; all 15 subjects studied were negative for androgen receptors. Conclusions: Since our data show that sex hormone receptors are absent in the vocal cords, other theories must be considered to explain the fact that hormones influence the quality of the voice. This study discusses the possibility that the changes of voice according to gender and throughout life might be linked with a different expression of some growth factors in the laryngeal tissue and that this expression might in turn be influenced by hormonal variations.

show abstract

“…Luego de 3 meses de seguimiento, basados en estudios con laringoestroboscopio y parámetros acústicos y aerodinámicos, notaron que mejora la atrofia vocal y los parámetros vocales aerodinámicos y desaparece la apertura glótica 32 . Se han realizado diversos estudios preclínicos en animales con células pluripotenciales endógenas y exógenas, con resultados prometedores, sin embargo la mayoría han sido en lesiones agudas de las cuerdas vocales 33 , por lo que no hay experiencia en el manejo en paciente con presbifonía.…”

Section: Cirugíaunclassified

Presbilaringe. Revisión de la literatura

Retuert

Olavarria

Frías

et al. 2017

Rev. Otorrinolaringol. Cir. Cabeza Cuello

View full text Add to dashboard Cite

INTRODUCCIONEl envejecimiento de la población obliga a un enfrentamiento de los nuevos desafíos médicos que se producirán por las condiciones degenerativas que acompañan dicho proceso.En Chile, según cifras del Instituto Nacional de Estadísticas, los adultos mayores correspondían a 11% de la población en el año 2002, mientras que en 2014 constituían 15%, dando cuenta del acelerado crecimiento de este grupo.

show abstract

Therapeutic Potential of Growth Factors for Aging Voice

Abstract: The present results suggest that growth factors, especially basic fibroblast growth factor, may have therapeutic potential in restoration of aged vocal fold.

Cited by 86 publications

References 18 publications

The Shear Modulus of the Human Vocal Fold in a Transverse Direction

The Shear Modulus of the Human Vocal Fold in a Transverse Direction

Sex Hormone Receptors in Vocal Fold Tissue: A Theory about the Influence of Sex Hormones in the Larynx

Presbilaringe. Revisión de la literatura

Contact Info

Product

Resources

About