Therapeutic potential of herbal medicine for the management of hyperlipidemia: latest updates

Rauf, Abdur; Akram, Muhammad; Anwar, Hina; Daniyal, Muhammad; Munir, Naveed; Bawazeer, Saud; Rebezov, Мaksim; Bouyahya, Abdelhakim; Shariati, Mohammad Ali; Thiruvengadam, Muthu; Sarsembenova, Orynzhamal; Mabkhot, Yahia N.; Islam, Mohammad Nazmul; Emran, Talha Bin; Zengin, Gökhan; Khan, Haroon

doi:10.1007/s11356-022-19733-7

Cited by 38 publications

(23 citation statements)

References 162 publications

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“…As a result, this extract improved rat oral glucose tolerance while inhibiting pancreatic α -amylase (IC 50 = 0.44 ± 0.05 μ g/mL) and intestinal α -glucosidase (IC 50 = 131 ± 20 μ g/mL) [ 61 ]. The promising results of these two species are likely due to their major bioactive molecules, which have been scientifically shown to have the antidiabetic potential [ 62 ]. These molecules were found and determined in the phytochemical section.…”

Section: Resultsmentioning

confidence: 99%

Determination of Volatile Compounds of Mentha piperita and Lavandula multifida and Investigation of Their Antibacterial, Antioxidant, and Antidiabetic Properties

Al-Mijalli

Elsharkawy

Abdallah

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Mentha piperita and Lavandula multifida are widely used in Moroccan traditional medicine for the treatment of diabetes and infectious diseases. The aims of this work were the determination of the chemical composition of Mentha piperita (MPEO) and Lavandula multifida (LMEO) essential oils and the evaluation of their antibacterial, antioxidant, and antidiabetic activities. The chemical composition was determined by GC-MS analysis. The antibacterial effects were evaluated against several bacterial strains using disc diffusion, MIC, and MBC methods. The antioxidant activity was evaluated in vitro using DPPH, H2O2, and xanthine oxidase, and the antidiabetic activity was estimated by the inhibitory effects of α-amylase, α-glucosidase, and lipase activities. GC-MS results showed that the main compounds of MPEO were menthone (29.24%), levomenthol (38.73%), and eucalyptol (6.75%). However, eucalyptol (28.11%), 2-bornanone (11.57%), endo-borneol (7.82%), and linalyl acetate (5.22%) are the major compounds of LMEO. The results exhibited important inhibitory effects against some bacterial strains with MIC = MBC = 0.39 mg/mL for MPEO against Staphylococcus aureus ATCC. However, LMEO exhibited remarkable antioxidant and antidiabetic activities compared to MPEO. Indeed, LMEO inhibited DPPH, H2O2, and xanthine oxidase with concentrations of 15.23, 21.52, and 8.89 µg/mL, respectively. Moreover, LMEO exhibited α-amylase and α-glucosidase at IC50 = 85.34 and IC50 = 59.36 µg/mL, respectively. The findings showed that both MPEO and LMEO exhibit promising biological properties. However, the application of these species or their main bioactive compounds requires further investigation.

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Section: Resultsmentioning

confidence: 99%

Determination of Volatile Compounds of Mentha piperita and Lavandula multifida and Investigation of Their Antibacterial, Antioxidant, and Antidiabetic Properties

Al-Mijalli

Elsharkawy

Abdallah

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…In other studies, Mentha canalenisa [ 72 ] and Mentha longifolia [ 73 ] showed an important inhibition against α-amylase and α-glucosidase activities. The promising results of these two species could be attributed to their chemical compounds, which are known for their antidiabetic potential [ 74 ].…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Variability, In Vitro and In Vivo Biological Investigations, and In Silico Antibacterial Mechanisms of Mentha piperita Essential Oils Collected from Two Different Regions in Morocco

Al-Mijalli

Mrabti

Ouassou

et al. 2022

Foods

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The objective of this work is to explore the phytochemical profile of Mentha piperita essential oils (MPEO) collected from two different Moroccan regions using gas chromatography-mass spectrophotometer (GC-MS) and to investigate their antioxidant, anti-inflammatory, antidiabetic and, antimicrobial effects using in vivo and in vitro assays. The chemical constituent of MPEO from the Azrou zone is dominated by carvone (70.25%), while MPEO from the Ouazzane zone is rich in Menthol (43.32%) and Menthone (29.4%). MPEO from Ouezzane showed higher antioxidant activity than EO from Azrou. Nevertheless, EO from Ouezzane considerably inhibited 5-Lipoxygenase (IC50 = 11.64 ± 0.02 µg/mL) compared to EO from Azro (IC50 = 23.84 ± 0.03 µg/mL). Both EOs from Azrou and Ouazzane inhibited the α-amylase activity in vitro, with IC50 values of 131.62 ± 0.01 µg/mL and 91.64 ± 0.03 µg/mL, respectively. The EOs were also tested for minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The discdiffusion test revealed that MPEOs from both regions have significant antibacterial efficacy, and MPEOs from the north region showed the highest effect. The gram-positive bacteria were the most susceptible organisms. The MIC concentrations were in the range of 0.05 to 6.25 mg/mL, and the MBC concentrations were within 0.05–25.0 mg/mL. The MBC/MIC index indicated that MPEO has strong bactericidal effects.

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“…The widely used lipid-lowering drugs such as statins, fibrates, bile acid sequestrates and niacin, have shown great potential in preventing and treating dyslipidemia ( 5 ). Many synthetic anti-obesity medications have also been used to improve dyslipidemia, as obesity is an important risk for dyslipidemia; however, they all exert undesirable adverse reactions such as myopathy, pancreatitis ( 6 ), and transaminase elevations, as well as treatment resistance, which may hinder medication compliance ( 7 , 8 ). Therefore, any treatment that safely lowers lipid levels is in great demand for the management of dyslipidemia and obesity.…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota mediates positive effects of liraglutide on dyslipidemia in mice fed a high-fat diet

Zhao

Qiu

Zhang³

et al. 2022

Front. Nutr.

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Except for improving glycemic control, liraglutide, one of the glucagon-like peptide-1 receptor agonists, has exerted promising therapeutic effects for dyslipidemia. It has been proved that gut microbiota plays a dramatic role in regulating lipid metabolism. This study aims to explore whether liraglutide could improve dyslipidemia by modulating the gut microbiota in mice fed a high-fat diet (HFD). The C57BL/6 mice were fed a HFD to establish an animal model of dyslipidemia, and then administered with liraglutide or normal saline (NS) for 12 weeks. Indices of glucolipid metabolism were evaluated. Gut microbiota of the mice was analyzed by 16S rRNA gene sequencing. Compared with HFD group, liraglutide significantly alleviated weight, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL) levels, meanwhile elevating high-density lipoprotein cholesterol (HDL) levels (all p < 0.05). The gut microbiota analysis revealed that liraglutide greatly reduced the relative abundance of Firmicutes and augmented that of Bacteroidetes, with a concomitant drop in the Firmicutes/Bacteroidetes ratio. Meanwhile, liraglutide dramatically changed the overall composition, promoted the growth of beneficial microbes (Akkermansia, Lactobacillus, Parabacteroides, Oscillospira, etc.), and inhibited the growth of harmful microbes (AF12, Shigella, Proteobacteria, Xenorhabdus, etc.). Especially, the relative abundance of Akkermansia increased the most after liraglutide treatment. Correlation analysis suggested that TC and LDL were positively correlated with some harmful bacteria, and negatively associated with beneficial bacteria. This study confirmed that liraglutide had a certain therapeutic effect on dyslipidemia in HFD-fed mice and could regulate the composition of the gut microbiota associated with lipid metabolism, especially Akkermansia. Thus, affecting gut microbiota might be a potential mechanism of liraglutide in attenuating dyslipidemia.

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Therapeutic potential of herbal medicine for the management of hyperlipidemia: latest updates

Cited by 38 publications

References 162 publications

Determination of Volatile Compounds of Mentha piperita and Lavandula multifida and Investigation of Their Antibacterial, Antioxidant, and Antidiabetic Properties

Determination of Volatile Compounds of Mentha piperita and Lavandula multifida and Investigation of Their Antibacterial, Antioxidant, and Antidiabetic Properties

Phytochemical Variability, In Vitro and In Vivo Biological Investigations, and In Silico Antibacterial Mechanisms of Mentha piperita Essential Oils Collected from Two Different Regions in Morocco

Gut microbiota mediates positive effects of liraglutide on dyslipidemia in mice fed a high-fat diet

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