Therapeutic Potential of Hydrazones as Anti-Inflammatory Agents

Abstract

Hydrazones are a special class of organic compounds in the Schiff base family. Hydrazones constitute a versatile compound of organic class having basic structure (R1R2C=NNR3R4). The active centers of hydrazone, that is, carbon and nitrogen, are mainly responsible for the physical and chemical properties of the hydrazones and, due to the reactivity toward electrophiles and nucleophiles, hydrazones are used for the synthesis of organic compound such as heterocyclic compounds with a variety of biological activities. Hydrazones and their derivatives are known to exhibit a wide range of interesting biological activities like antioxidant, anti-inflammatory, anticonvulsant, analgesic, antimicrobial, anticancer, antiprotozoal, antioxidant, antiparasitic, antiplatelet, cardioprotective, anthelmintic, antidiabetic, antitubercular, trypanocidal, anti-HIV, and so forth. The present review summarizes the efficiency of hydrazones as potent anti-inflammatory agents.

Quinoline based mono- and bis-(thio)carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models

“…They are known to possess a broad spectrum of biological activities such as antioxidant, analgesic, antiplatelet, antimicrobial, anticonvulsant, antidepressant, anti-inammatory, anti-tubercular, cardio protective, anti-HIV, anthelmintic, anti-diabetic, trypanocidal and anticancer activities. [1][2][3][4][5][6] Many of these compounds were patented in this respect. 7 Monohydrazide derivatives of carbonic and thiocarbonic acid, semicarbazide and thiosemicarbazide, respectively react with N-heteroaromatic carbonyl compounds giving (thio)semicarbazones -molecules well described as tridentate NNO(S) chelators and ribonucleotid reductase (RR) inhibitory agents.…”

Disruption of zinc and copper interactions with Aβ(1–40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer's disease therapy?

“…20 In sum, the results obtained in this study suggest that this isoniazid-derived hydrazone is an excellent candidate for further trials. Because of this, INHHQ is a promising compound, since it effectively inhibits Ab interaction with biometals and is atoxic at concentrations up to 300 mg kg À1 in a mammal model organism, as predicted by the in silico pharmacological analyses.…”

Novel tetrazole and cyanamide derivatives as inhibitors of cyclooxygenase-2 enzyme: design, synthesis, anti-inflammatory evaluation, ulcerogenic liability and docking study

“…On the other hand, pyridine scaffold [23][24][25] was the base of many bioactive molecules especially anti-inflammatory agents. Moreover, pyrazoline ring [26][27][28][29] , hydrazone functionality 30 and chalcones [31][32][33] are attractive motifs for anti-inflammatory drugs. Non-steroidal anti-inflammatory drugs (NSAIDs) are of great importance in the treatment of inflammation and pain.…”