Therapeutic potential ofMoringa oleiferaextracts against acetaminophen-induced hepatotoxicity in rats

Protective Effects of Moringa oleifera extract on Isoniazid and Rifampicin Induced Hepatotoxicity in Rats: Involvment of Adiponectin and Tumor Necrosis Factor-α

“…Morever, Moringa oleifera extract administered to rats histopathological figure revealed individual cell necrosis of the periportal hepatocytes in histopathological examination experiment result in the same boat with Saalu et al [54] and Sharifudin et al [62]. silymarin has a minimal reduction in the severity of the liver damage as shown vacuolar degeneration of hepatocytes associated with sporadic cell necrosis.…”

The molecular mechanism underlying the hepatoprotective potential of Moringa oleifera leaves extract against acetaminophen induced hepatotoxicity in mice

“…Our previous study has demonstrated that MO leaves extract successfully alleviated APAP induced hepatotoxicity through its anti-oxidative nature and GSH level restoration (Fakurazi, Hairuszah, & Nanthini, 2008;Sharifudin et al, 2012), and also reported the bioactive compounds responsible for its enriched antioxidant activity (Karthivashan, Arulselvan, Alimon, Safinar Ismail, & Fakurazi, 2015;Karthivashan et al, 2013). To date, no definite reports exist on the molecular mechanism of MO leaves extract against APAP hepatotoxicity.…”

“…1B). Subsequently, the leaves have been studied for its various therapeutic properties such as antimicrobial, antiinflammatory, anti-cancer, anti-diabetic effects (Anwar, Latif, Ashraf, & Gilani, 2007;Coppin et al, 2013) and has recently been evaluated for its hepatoprotective effects (Das, Sikder, Ghosh, Fromenty, & Dey, 2012;Sharifudin et al, 2012). However, most of the reported studies have focused on the evaluation of their efficacy but not at its molecular level mechanism of action.…”

Assessment of ameliorative effects of aqueous extracts of Moringa oleifera on acetaminophen -induced nephrotoxicity in rats

“…Our results in this study showed that, treatment of rats with M. oleifera aqueous extracts doses of 250, 500 and 100 mg/kg reduced the alteration levels of biochemical parameters induced by APAP and these results suggest the possibility of extracts to have ability to stabilize kidney dysfunction in rat during renal injury with APAP. Indeed, aqueous extracts of M. oleifera may reduce the alteration sera levels induced by APAP; due to its ability to stabilize kidney dysfunction in rats following APAP overdoses and that might be due to the highly antioxidant activities found on this plant and thus successfully decreasing oxidations which response of causing nephrotoxicity [32]. Increase levels of free NAPQI following the depletion of cellular GSH levels will enhances cellular injuries and cause renal dysfunction, however, recently report by Fakurazi and co-workers found that aqueous extract of M. oleifera leaves against APAP toxicity is due to its ability to restoration or promoting GSH through decrease the biotransformation of APAP via cytochrome P450 pathway, and thus inhibits toxic metabolism of APAO to free NAPQI which leads to GSH depletion [33].…”