Therapeutic potential of IGF-I on hippocampal neurogenesis and function during aging

Morel, Gustavo Ramón; León, Micaela López; Uriarte, Maia; Reggiani, Paula C.; Goya, Rodolfo G.

doi:10.1080/23262133.2016.1259709

Cited by 31 publications

(19 citation statements)

References 37 publications

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“…Neurodegenerative diseases like Alzheimer's, Parkinson's diseases and prion disorders are associated with aging [88][89][90][91][92]. A number of promising results show that IGF-1 has a restorative impact on the brain by expanding hippocampal neurogenesis and memory accuracy in older people and potentially in individuals with neurodegenerative disorders [93]. IGF-1 has a progressively more powerful trophic impact than GH on sensory and motor neurons and on neuronal growth and recovery.…”

Section: Role Of Igf-1 In Neurodegenerationmentioning

confidence: 99%

Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases

Ahmad

Lee

et al. 2020

Cells

116

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Skeletal muscle is an essential tissue that attaches to bones and facilitates body movements. Insulin-like growth factor-1 (IGF-1) is a hormone found in blood that plays an important role in skeletal myogenesis and is importantly associated with muscle mass entity, strength development, and degeneration and increases the proliferative capacity of muscle satellite cells (MSCs). IGF-1R is an IGF-1 receptor with a transmembrane location that activates PI3K/Akt signaling and possesses tyrosine kinase activity, and its expression is significant in terms of myoblast proliferation and normal muscle mass maintenance. IGF-1 synthesis is elevated in MSCs of injured muscles and stimulates MSCs proliferation and myogenic differentiation. Mechanical loading also affects skeletal muscle production by IGF-1, and low IGF-1 levels are associated with low handgrip strength and poor physical performance. IGF-1 is potentially useful in the management of Duchenne muscular dystrophy, muscle atrophy, and promotes neurite development. This review highlights the role of IGF-1 in skeletal muscle, its importance during myogenesis, and its involvement in different disease conditions.

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Section: Role Of Igf-1 In Neurodegenerationmentioning

confidence: 99%

Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases

Ahmad

Lee

et al. 2020

Cells

116

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“…The bioavailability of IGF-1 and IGF-2 and their binding proteins (IGF-BP2 and IGF-BP3) could play an important role in the prevention and treatment of several neurologic disorders [ 49 ]. Emerging promising results demonstrates that IGF-1 possesses a therapeutic effect on the brain by increasing hippocampal neurogenesis and memory accuracy in elderly individuals, and possibly, in neurodegenerative disorders [ 50 ]. Mashayekhi et al [ 51 ] found the serum level of IGF-1 and IGFBPs were higher in patients affected by Parkinson disease compared to controls, but the significance of these data in the pathophysiology of the disease remains unexplained.…”

Section: Introductionmentioning

confidence: 99%

Neurotrophic and Neuroregenerative Effects of GH/IGF1

Bianchi¹,

Locatelli

Rizzi

2017

IJMS

161

109

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Introduction. Human neurodegenerative diseases increase progressively with age and present a high social and economic burden. Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are both growth factors exerting trophic effects on neuronal regeneration in the central nervous system (CNS) and peripheral nervous system (PNS). GH and IGF-1 stimulate protein synthesis in neurons, glia, oligodendrocytes, and Schwann cells, and favor neuronal survival, inhibiting apoptosis. This study aims to evaluate the effect of GH and IGF-1 on neurons, and their possible therapeutic clinical applications on neuron regeneration in human subjects. Methods. In the literature, we searched the clinical trials and followed up studies in humans, which have evaluated the effect of GH/IGF-1 on CNS and PNS. The following keywords have been used: “GH/IGF-1” associated with “neuroregeneration”, “amyotrophic lateral sclerosis”, “Alzheimer disease”, “Parkinson’s disease”, “brain”, and “neuron”. Results. Of the retrieved articles, we found nine articles about the effect of GH in healthy patients who suffered from traumatic brain injury (TBI), and six studies (four using IGF-1 and two GH therapy) in patients with amyotrophic lateral sclerosis (ALS). The administration of GH in patients after TBI showed a significantly positive recovery of brain and mental function. Treatment with GH and IGF-1 therapy in ALS produced contradictory results. Conclusions. Although strong findings have shown the positive effects of GH/IGF-1 administration on neuroregeneration in animal models, a very limited number of clinical studies have been conducted in humans. GH/IGF-1 therapy had different effects in patients with TBI, evidencing a high recovery of neurons and clinical outcome, while in ALS patients, the results are contradictory. More complex clinical protocols are necessary to evaluate the effect of GH/IGF-1 efficacy in neurodegenerative diseases. It seems evident that GH and IGF-1 therapy favors the optimal recovery of neurons when a consistent residual activity is still present. Furthermore, the effect of GH/IGF-1 could be mediated by, or be overlapped with that of other hormones, such as estradiol and testosterone.

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“…The possibility exists that GH induced the local expression of IGF-1, as it has been demonstrated in the human fetal cortex [33], but not in human adult brain. In fact, an important role for IGF-1 in neurodegenerative diseases has been postulated long time ago [34], and recently it has been published that IGF-1 increases hippocampal neurogenesis and improves memory in old patients [35]. Even more, it has been postulated that treatment with this peptide might be useful in neurodegenerative diseases, including Alzheimer's disease [36].…”

Section: Discussionmentioning

confidence: 99%

Growth Hormone (GH) Administration Increases the Metabolic Activity of the left Hippocampus in an Elder Patient with Cognitive Disorders

Devesa¹,

Núñez²,

Agra³

et al. 2018

Preprint

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1) Background: We analyzed, by PET-SCAN, how growth hormone (GH) might act on the brain of a not GH-deficient elder woman who suspected that she was developing Alzheimer's disease; 2) Methods: After performing a first psychometric study (TAVEC verbal learning test), the metabolic activity of brain structures related to cognition, memory and behavior was analyzed by 18-F Fluorodeoxyglucose PET-SCAN. The patient was then treated with GH (0.4 mg/day) during three weeks and the last day under this treatment a new PET-SCAN was carried out. One month after commencing the treatment with GH a new TAVEC test was performed; 3) Results: GH administration normalized the cognitive deficits observed in the first cognitive test and significantly (p < 0.025) increased (Voxel-Based Morphometry) the metabolic activity in the left hippocampus, left amygdala and left parahippocampus, but also in practically all brain cortical areas; 4) Conclusions: This is the first study in which the effects of GH on the brain have been visualized in images. Our data confirm the positive effects of this hormone on cognition and memories; although they do not allow us to conclude whether GH administration may be useful in the early stages of Alzheimer's disease, they seem to be promising.

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Therapeutic potential of IGF-I on hippocampal neurogenesis and function during aging

Cited by 31 publications

References 37 publications

Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases

Implications of Insulin-Like Growth Factor-1 in Skeletal Muscle and Various Diseases

Neurotrophic and Neuroregenerative Effects of GH/IGF1

Growth Hormone (GH) Administration Increases the Metabolic Activity of the left Hippocampus in an Elder Patient with Cognitive Disorders

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