Therapeutic Potential of Marine Bioactive Peptides against Human Immunodeficiency Virus: Recent Evidence, Challenges, and Future Trends

Al-Khayri, Jameel M.; Asghar, Waqas; Khan, Sipper; Akhtar, Aqsa; Ayub, Haris; Khalid, Nauman; Alessa, Fatima Mohammed; Al-Mssallem, Muneera Qassim; Rezk, Adel A.; Shehata, Wael Fathi

doi:10.3390/md20080477

Cited by 3 publications

(3 citation statements)

References 158 publications

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“…Peptide drugs have the advantages of higher bioactivity, selectivity, permeability, target potency and safety compared with small-molecule and protein drugs 25 . Therefore, peptides have been widely used in the treatment of cancer, diabetes, acquired immunodeficiency syndrome and cardiovascular diseases 26 , 27 , 28 , 29 . Our previous studies revealed that the antioxidant peptide DR8 (DHNNPQIR-NH 2 ) derived from rapeseed protein showed low toxicity and an inhibitory effect on organ fibrosis, such as lung, kidney and liver fibrosis 30 , 31 , 32 .…”

Section: Introductionmentioning

confidence: 99%

A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis

Wang

Deng²,

Cheng³

et al. 2023

Acta Pharmaceutica Sinica B

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Section: Introductionmentioning

confidence: 99%

A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis

Wang

Deng²,

Cheng³

et al. 2023

Acta Pharmaceutica Sinica B

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“…Plants, or more precisely, plant-isolated bioactive compounds, are being used to lower oxidative stress and to aid the treatment of a range of disorders as their health-beneficial qualities become more widely acknowledged. Furthermore, this aim is more applicable to disorders that are caused by or are impacted by oxidative stress [ 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

From Plants to Psycho-Neurology: Unravelling the Therapeutic Benefits of Bioactive Compounds in Brain Disorders

2023

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The brain′s sensitivity to oxidative stress and neuronal cell death requires effective pharmacotherapy approaches. Current pharmacological therapies are frequently ineffective and display negative side effects. Bioactive chemicals found in plants may provide a potential alternative due to their antioxidant and neuroprotective properties and can be used in therapy and the management of a variety of neuropsychiatric, neurodevelopmental, and neurodegenerative illnesses. Several natural products, including vitamin C, Cammelia sinensis polyphenols, Hypericum perforatum, and Crocus sativus have shown promise in lowering oxidative stress and treating symptoms of major depressive disorder (MDD). Similarly, bioactive compounds such as curcumin, luteolin, resveratrol, quercetin, and plants like Acorus gramineus, Rhodiola rosea, and Ginkgo biloba are associated with neuroprotective effects and symptom improvement in neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). Furthermore, in neurodegenerative diseases, natural compounds from Rhodiola rosea, Morinda lucida, and Glutinous rehmannia provide neurological improvement. Further study in clinical samples is required to thoroughly investigate the therapeutic advantages of these bioactive substances for persons suffering from these illnesses.

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“…Marine species are abundant sources of bioactive substances with a wide range of structural variations and biological activity and are becoming increasingly significant as a source of novel bioactive compounds [19]. These peptides are reportedly found in sponges, ascidians, seaweed, and mollusks and exhibit a variety of pharmacological characteristics [20,21]. Bioactive peptides have been identified as certain protein fragments that have a favorable effect on physiological conditions or processes and may have a health-promoting effect [22].…”

Section: Introductionmentioning

confidence: 99%

Insights into Common Octopus (Octopus vulgaris) Ink Proteome and Bioactive Peptides Using Proteomic Approaches

et al. 2023

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The common octopus (Octopus vulgaris) is nowadays the most demanded cephalopod species for human consumption. This species was also postulated for aquaculture diversification to supply its increasing demand in the market worldwide, which only relies on continuously declining field captures. In addition, they serve as model species for biomedical and behavioral studies. Body parts of marine species are usually removed before reaching the final consumer as by-products in order to improve preservation, reduce shipping weight, and increase product quality. These by-products have recently attracted increasing attention due to the discovery of several relevant bioactive compounds. Particularly, the common octopus ink has been described as having antimicrobial and antioxidant properties, among others. In this study, the advanced proteomics discipline was applied to generate a common octopus reference proteome to screen potential bioactive peptides from fishing discards and by-products such as ink. A shotgun proteomics approach by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) using an Orbitrap Elite instrument was used to create a reference dataset from octopus ink. A total of 1432 different peptides belonging to 361 non-redundant annotated proteins were identified. The final proteome compilation was investigated by integrated in silico studies, including gene ontology (GO) term enrichment, pathways, and network studies. Different immune functioning proteins involved in the innate immune system, such as ferritin, catalase, proteasome, Cu/Zn superoxide dismutase, calreticulin, disulfide isomerase, heat shock protein, etc., were found in ink protein networks. Additionally, the potential of bioactive peptides from octopus ink was addressed. These bioactive peptides can exert beneficial health properties such as antimicrobial, antioxidant, antihypertensive, and antitumoral properties and are therefore considered lead compounds for developing pharmacological, functional foods or nutraceuticals.

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Therapeutic Potential of Marine Bioactive Peptides against Human Immunodeficiency Virus: Recent Evidence, Challenges, and Future Trends

Cited by 3 publications

References 158 publications

A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis

A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis

From Plants to Psycho-Neurology: Unravelling the Therapeutic Benefits of Bioactive Compounds in Brain Disorders

Insights into Common Octopus (Octopus vulgaris) Ink Proteome and Bioactive Peptides Using Proteomic Approaches

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