Therapeutic potential of marine n-3 fatty acids in CABG patients

Andreasen, Jan Jesper; Schmidt, Erik Berg

doi:10.1016/j.coph.2012.01.012

Cited by 4 publications

(1 citation statement)

References 53 publications

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“…The metabolites of arachidonic acid, EPA and DHA are intimately involved in wound healing and other immune challenges ( 31 ) . The initial Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione study ( 32 ) and the Japan EPA Lipid Intervention Study ( 33 ) supported the use of fish oil supplements in secondary prevention of CHD; however, a recent meta-analysis ( 34 ) and a systematic review ( 35 ) have yielded conflicting results, probably because fish oil may not add a preventive effect_ on top of the highly effective current drug treatment ( 36 ) . However, EPA and DHA also exhibit protective effects on cognitive decline and depression ( 37 ) , conditions that are increasingly recognised as inflammatory diseases ( 38 , 39 ) .…”

Section: Discussionmentioning

confidence: 99%

Patients undergoing elective coronary artery bypass grafting exhibit poor pre-operative intakes of fruit, vegetables, dietary fibre, fish and vitamin D

et al. 2015

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CHD may ensue from chronic systemic low-grade inflammation. Diet is a modifiable risk factor for both, and its optimisation may reduce post-operative mortality, atrial fibrillation and cognitive decline. In the present study, we investigated the usual dietary intakes of patients undergoing elective coronary artery bypass grafting (CABG), emphasising on food groups and nutrients with putative roles in the inflammatory/anti-inflammatory balance. From November 2012 to April 2013, we approached ninety-three consecutive patients (80 % men) undergoing elective CABG. Of these, fifty-five were finally included (84 % men, median age 69 years; range 46 -84 years). The median BMI was 27 (range 18-36) kg/m . The percentages of patients with dietary intakes above recommendations were 95 % (saturated fat; recommendation ,10 E%) and 7 % (LA). The dietary intakes of patients proved comparable with the average nutritional intake of the age-and sex-matched healthy Dutch population. These unbalanced pre-operative diets may put them at risk of unfavourable surgical outcomes, since they promote a pro-inflammatory state. We conclude that there is an urgent need for intervention trials aiming at rapid improvement of their diets to reduce peri-operative risks.

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