Therapeutic potential of miRNAs targeting SARS-CoV-2 host cell receptor ACE2

Bozgeyik, İbrahim

doi:10.1016/j.mgene.2020.100831

Cited by 30 publications

(23 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…miRNAs express ubiquitously across species and play significant roles in the development and perform diverse regulatory functions in cells, including viral infections ( Głobińska et al, 2014 ; Rossi et al, 2015 ). In many cases, miRNAs have been proposed as minimally invasive markers for the early detection of diseases, and human encoded miRNAs could be the finest candidates for the development of miRNA-based therapeutics in the management of SARS-CoV-2 infection ( Bozgeyik, 2021 ). In this study, we purposed to investigate the levels of miR-200c-3p and miR-421-5p in admitted and recovered COVID-19 patients and seeking their correlations with inflammation and tolerance-related gene expressions.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of miR-200c-3p and miR-421-5p levels during immune responses in the admitted and recovered COVID-19 subjects

Abdolahi

Hosseini

Rezaei

et al. 2022

Infection, Genetics and Evolution

View full text Add to dashboard Cite

Angiotensin-converting enzyme 2 (ACE2) acts as a key receptor for the spike of SARS-CoV-2. Two main microRNAs (miRs), miR-200c-3p and miR-421-5p, are considered to modulate the expression of ACE2 gene and alterations in the expression of these miRNAs may influence the outcomes of COVID-19 infection. Accordingly, we examined whether miRNAs directing ACE2 expression altered in the SARS-CoV-2 infection. 30 patients with COVID-19 included in the study. At the time of admission and discharge, the expression of miR-200c-3p and miR-421-5p, inflammatory cytokine IL-6, and regulatory T cells' expression profiles (CD4, CD25, and Foxp3) were examined using quantitative real-time PCR method. At the time of admission, the expression levels of miR-200c-3p and miR-421-5p as well as CD4, CD25, and Foxp3 significantly decreased while IL-6 expression notably enhanced. However, by the time of discharge, the expression levels of the genes were opposite to the time of admission. Moreover, Pearson correlation analysis indicated that IL-6 expression negatively correlated with Foxp3 and miR-200c-3p expressions despite miR-421-5p and miR-200c-3p positively correlated at admission time. By manipulating miR-200c-3p and miR-421-5p expressions and controlling the ACE2 level, it is plausible to modulate the inflammation by reducing IL-6 and maintenance tolerance hemostasis during COVID-19 infection.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of miR-200c-3p and miR-421-5p levels during immune responses in the admitted and recovered COVID-19 subjects

Abdolahi

Hosseini

Rezaei

et al. 2022

Infection, Genetics and Evolution

View full text Add to dashboard Cite

show abstract

“…Mir-200 family has been well characterized in cancer with numerous reports on its tumor suppressive action in multiple human cancers [ 271 , 272 ], including in lung cancer [ 81 , 273 ]. Members of this family can regulate ACE2, with miR-200c possibly the strongest candidate miRNA that can target ACE2 in respiratory cells [ 274 ]. Additionally, members of miR-200 family have been reported to regulate inflammation.…”

Section: Micrornas As Epigenetic Regulators Connecting Inflammation mentioning

confidence: 99%

Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19

Ahmad

Manzoor

Siddiqui

et al. 2022

Seminars in Cancer Biology

View full text Add to dashboard Cite

Inflammation is an essential component of several respiratory diseases, such as chronic obstructive pulmonary disease (COPD), asthma and acute respiratory distress syndrome (ARDS). It is central to lung cancer, the leading cancer in terms of associated mortality that has affected millions of individuals worldwide. Inflammation and pulmonary manifestations are also the major causes of COVID-19 related deaths. Acute hyperinflammation plays an important role in the COVID-19 disease progression and severity, and development of protective immunity against the virus is greatly sought. Further, the severity of COVID-19 is greatly enhanced in lung cancer patients, probably due to the genes such as ACE2, TMPRSS2, PAI-1 and furin that are commonly involved in cancer progression as well as SAR-CoV-2 infection. The importance of inflammation in pulmonary manifestations, cancer and COVID-19 calls for a closer look at the underlying processes, particularly the associated increase in IL-6 and other cytokines, the dysregulation of immune cells and the coagulation pathway. Towards this end, several reports have identified epigenetic regulation of inflammation at different levels. Expression of several key inflammation-related cytokines, chemokines and other genes is affected by methylation and acetylation while non-coding RNAs, including microRNAs as well as long non-coding RNAs, also affect the overall inflammatory responses. Select miRNAs can regulate inflammation in COVID-19 infection, lung cancer as well as other inflammatory lung diseases, and can serve as epigenetic links that can be therapeutically targeted. Furthermore, epigenetic changes also mediate the environmental factors-induced inflammation. Therefore, a better understanding of epigenetic regulation of inflammation can potentially help develop novel strategies to prevent, diagnose and treat chronic pulmonary diseases, lung cancer and COVID-19.

show abstract

“…It has been evident that upregulation of miR-181a is associated with upregulation of signaling cascades of adaptive immunity and inflammation [130] . Thus, forced expression of this miR can serve as a therapeutic agent for COVID-19 [131] . Another miRNA that can specifically be targeted for curing COVID-19 in patients with chronic kidney disease is miR-421 ( Fig.…”

Section: Kidney Disease and Covid-19mentioning

confidence: 99%

“…Another miRNA that can specifically be targeted for curing COVID-19 in patients with chronic kidney disease is miR-421 ( Fig. 2 ) [131] . Trojanowicz et al, have shown that miR-421 binds to 3'-UTR of the ACE2 mRNA [132] .…”

Section: Kidney Disease and Covid-19mentioning

confidence: 99%

Role of microRNAs in COVID-19 with implications for therapeutics

Arghiani¹,

Nissan²,

Matin³

2021

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

COVID-19 is a pneumonia-like disease with highly transmittable and pathogenic properties caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which infects both animals and humans. Although many efforts are currently underway to test possible therapies, there is no specific FDA approved drug against SARS-CoV-2 yet. miRNA-directed gene regulation controls the majority of biological processes. In addition, the development and progression of several human diseases are associated with dysregulation of miRNAs. In this regard, it has been shown that changes in miRNAs are linked to severity of COVID-19 especially in patients with respiratory diseases, diabetes, heart failure or kidney problems. Therefore, targeting these small noncoding-RNAs could potentially alleviate complications from COVID-19. Here, we will review the roles and importance of host and RNA virus encoded miRNAs in COVID-19 pathogenicity and immune response. Then, we focus on potential miRNA therapeutics in the patients who are at increased risk for a severe disease.

show abstract

Therapeutic potential of miRNAs targeting SARS-CoV-2 host cell receptor ACE2

Cited by 30 publications

References 31 publications

Evaluation of miR-200c-3p and miR-421-5p levels during immune responses in the admitted and recovered COVID-19 subjects

Evaluation of miR-200c-3p and miR-421-5p levels during immune responses in the admitted and recovered COVID-19 subjects

Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19

Role of microRNAs in COVID-19 with implications for therapeutics

Contact Info

Product

Resources

About