2009
DOI: 10.1007/s11095-009-0023-z
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Therapeutic Potential of New 4-hydroxy-tamoxifen-Loaded pH-gradient Liposomes in a Multiple Myeloma Experimental Model

Abstract: This antitumor effect was assumed to be the result of a modified biodistribution of 4HT once trapped in DL-9 liposomes. Such 4HT-containing pH-gradient Stealth nanocarriers could be helpful for MM treatment.

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Cited by 16 publications
(8 citation statements)
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“…caspase 3, 1/100, #9661S, Cell signaling Tech. ), a marker of apoptosis according to [24]. N-Histofine Simple Stain anti-rat and N-Histofine anti-mouse stain kits (both from Nichirei, Japan) were used for CD34 and CD138 detection, respectively.…”
Section: Methodsmentioning
confidence: 99%
“…caspase 3, 1/100, #9661S, Cell signaling Tech. ), a marker of apoptosis according to [24]. N-Histofine Simple Stain anti-rat and N-Histofine anti-mouse stain kits (both from Nichirei, Japan) were used for CD34 and CD138 detection, respectively.…”
Section: Methodsmentioning
confidence: 99%
“… 2 This resulted in much higher cytotoxicity than what was observed in cells treated with free ADR, indicating that this polymer nanocomplex might effectually reverse ADR resistance in MCF7 cells. In another study, 34 4-OHT-loaded pH-gradient pegylated liposomes were formulated by varying the composition of lipids and external pH for 4-OHT loading and were delivered to MCF7 cells as well as in multiple myeloma (MM) cells. 33 , 34 These liposomes resulted in greater stability, low relative toxicity, and slow 4-OHT release compared to that of conventional non-pH-gradient liposomes, and they blocked MM tumor growth at 4 mg/kg/week in vivo after 6 weeks of treatment.…”
Section: Introductionmentioning
confidence: 99%
“…Although myeloma cells express estrogen receptors (ER) belonging to both α and β isotypes [ 4 , 5 ],it is not clear if AEs signal through canonical ERs. Nevertheless, in vivo experiments with xenografted mice bearing MM tumors clearly demonstrated that the 4-hydroxy-tamoxifen (OHT) as well as the pure AE, RU 58668 block tumor growth [ 8 , 9 ]. This strongly supports that SERMs and SERDs may provide an alternative therapy for MM patients.…”
Section: Introductionmentioning
confidence: 99%