Therapeutic potential of Nigella sativa

Abdul-Rahman, Nor Zaihana; Mohd-Zubri, Nurul Szawani

doi:10.1016/b978-0-323-90788-0.00017-2

Biochemistry, Nutrition, and Therapeutics of Black Cumin Seed 2023

DOI: 10.1016/b978-0-323-90788-0.00017-2

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Therapeutic potential of Nigella sativa

Nor Zaihana Abdul-Rahman

Nurul Szawani Mohd-Zubri²

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2024

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Cited by 2 publications

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“…Sativa has traditionally been used as a bronchodilator, appetite stimulant, antibacterial, diuretic, liver tonic, and analgesic. N. sativa also exerts therapeutic effects on various conditions, including hypertension, cardiovascular disease, diabetes, cancer, rheumatic disorders, gastrointestinal disorders, diarrhea, skin disorders, infections, and asthma (25)(26)(27). The plant seeds contain thymoquinone, which is a bioactive compound with anti-inflammatory, antioxidant, and lipid-lowering effects (26,28,29).…”

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confidence: 99%

Effect of Nigella sativa Supplementation on Lipid Profile in Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Ccontrolled Trials

Aliyari,

Hashemy,

Ghavidel

et al. 2024

ABI

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Objectives: Type 2 diabetes has become a global health burden, especially in developing nations, and is frequently linked to dyslipidemia. While various medications are available, there is a growing interest in herbal remedies such as Nigella sativa (N. sativa) as alternative treatments for type 2 diabetes. In this systematic review and meta-analysis, the objective was to assess the impact of N. sativa on the lipid profile of patients with type 2 diabetes. Methods: Online databases, including Web of Science, Scopus, PubMed, and EMBASE, were searched. Changes in lipid profile parameters were reported as weighted mean differences, along with a 95% confidence interval. Sensitivity analysis, quality assessment, subgroup analysis, and publication bias were evaluated in the eligible studies. Results: The study was performed on eight randomized controlled trials (RCTs) involving 1030 participants. According to the findings, supplementation of N. sativa in the form of seed powder or oil significantly reduced total cholesterol and LDL-cholesterol levels, while increasing HDL-cholesterol levels in patients with type 2 diabetes. The funnel plot exhibited visual symmetry for the studies included in the meta-analysis. Conclusion: The findings indicate that N sativa may be beneficial as an adjunctive treatment alongside standard medications for managing dyslipidemia in individuals with type 2 diabetes.

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confidence: 99%

Effect of Nigella sativa Supplementation on Lipid Profile in Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Ccontrolled Trials

Aliyari,

Hashemy,

Ghavidel

et al. 2024

ABI

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Antimicrobial Properties and Therapeutic Potential of Bioactive Compounds in Nigella sativa: A Review

Abbas,

Gururani,

Ali

et al. 2024

Molecules

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Nigella sativa (N. sativa; Ranunculaceae), commonly referred to as black cumin, is one of the most widely used medicinal plants worldwide, with its seeds having numerous applications in the pharmaceutical and food industries. With the emergence of antibiotic resistance in pathogens as an important health challenge, the need for alternative microbe-inhibitory agents is on the rise, whereby black cumin has gained considerable attention from researchers for its strong antimicrobial characteristics owing to its high content in a wide range of bioactive compounds, including thymoquinone, nigellimine, nigellidine, quercetin, and O-cymene. Particularly, thymoquinone increases the levels of antioxidant enzymes that counter oxidative stress in the liver. Additionally, the essential oil in N. sativa seeds effectively inhibits intestinal parasites and shows moderate activity against some bacteria, including Bacillus subtilis and Staphylococcus aureus. Thymoquinone exhibits minimum inhibitory concentrations (MICs) of 8–16 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA) and exhibits MIC 0.25 µg/mL against drug-resistant mycobacteria. Similarly, quercetin shows a MIC of 2 mg/mL against oral pathogens, such as Streptococcus mutans and Lactobacillus acidophilus. Furthermore, endophytic fungi isolated from N. sativa have demonstrated antibacterial activity. Therefore, N. sativa is a valuable medicinal plant with potential for medicinal and food-related applications. In-depth exploration of the corresponding therapeutic potential and scope of industrial application warrants further research.

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Therapeutic potential of Nigella sativa

Cited by 2 publications

References 39 publications

Effect of Nigella sativa Supplementation on Lipid Profile in Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Ccontrolled Trials

Effect of Nigella sativa Supplementation on Lipid Profile in Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Ccontrolled Trials

Antimicrobial Properties and Therapeutic Potential of Bioactive Compounds in Nigella sativa: A Review

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