Therapeutic Potential of Oral-Derived Mesenchymal Stem Cells in Retinal Repair

Mohebichamkhorami, Fariba; Niknam, Zahra; Zali, Hakimeh; Mostafavi, Ebrahim

doi:10.1007/s12015-023-10626-x

Cited by 4 publications

(1 citation statement)

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“…Derived from the neural crest, dental MSCs uniquely express neural markers, secrete neurotrophic factors, and combine MSC-like characteristics with immunomodulation and neural features [ 73 ]. With their neural crest lineage, neuronal markers, and expression of neurotrophic factors, along with the potential for neurogenic differentiation, these cells are actively researched for their applications in treating neuronal diseases and injuries [ 74 , 75 ]. Recent studies highlight their promising role in neural tissue engineering for nerve regeneration, particularly in the treatment of SCI.…”

Section: The Neurodegenerative Potential Of Dental Stem Cellsmentioning

confidence: 99%

Advancements in Spinal Cord Injury Repair: Insights from Dental-Derived Stem Cells

Wen,

Jiang,

et al. 2024

Biomedicines

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Spinal cord injury (SCI), a prevalent and disabling neurological condition, prompts a growing interest in stem cell therapy as a promising avenue for treatment. Dental-derived stem cells, including dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHED), stem cells from the apical papilla (SCAP), dental follicle stem cells (DFSCs), are of interest due to their accessibility, minimally invasive extraction, and robust differentiating capabilities. Research indicates their potential to differentiate into neural cells and promote SCI repair in animal models at both tissue and functional levels. This review explores the potential applications of dental-derived stem cells in SCI neural repair, covering stem cell transplantation, conditioned culture medium injection, bioengineered delivery systems, exosomes, extracellular vesicle treatments, and combined therapies. Assessing the clinical effectiveness of dental-derived stem cells in the treatment of SCI, further research is necessary. This includes investigating potential biological mechanisms and conducting Large-animal studies and clinical trials. It is also important to undertake more comprehensive comparisons, optimize the selection of dental-derived stem cell types, and implement a functionalized delivery system. These efforts will enhance the therapeutic potential of dental-derived stem cells for repairing SCI.

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Section: The Neurodegenerative Potential Of Dental Stem Cellsmentioning

confidence: 99%